nanaomycin A

produced by a strain OS-3966 of Streptomyces rosa var. notoensis; quinone-related cpd; MF C16-H14-O6; see also nanaomycin B: 52934-85-7, nanaomycin C: 58286-55-8, nanaomycin E: 72660-52-7; structure

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Carell, Thomas: 1 article (12/2015)
2.	Frede, Ute: 1 article (12/2015)
3.	Hackner, Benjamin: 1 article (12/2015)
4.	Hagemeier, Christian: 1 article (12/2015)
5.	Maier, Bert: 1 article (12/2015)
6.	Penter, Livius: 1 article (12/2015)
7.	Truss, Matthias: 1 article (12/2015)
8.	Caulfield, Thomas: 1 article (11/2010)
9.	Kuck, Dirk: 1 article (11/2010)
10.	Lyko, Frank: 1 article (11/2010)

Related Diseases

1.	Neuroblastoma 01/01/2023 - "To study the antitumor activity of nanaomycin A against neuroblastoma cell lines and its mechanism. " 01/01/2023 - "Nanaomycin A is an effective therapeutic candidate for treating neuroblastoma. " 01/01/2023 - "Nanaomycin A decreased genomic DNA methylation levels and induced apoptosis in human neuroblastoma cells. " 01/01/2023 - "The DNMT3B Inhibitor Nanaomycin A as a Neuroblastoma Therapeutic Agent." 01/01/2023 - "The anti-tumor effect of nanaomycin A on neuroblastoma cell lines was evaluated based on cell viability, DNA methylation levels, apoptosis-related protein expression, and neuronal-associated mRNA expression. "
2.	Neoplasms (Cancer) 11/01/2010 - "Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells." 01/01/2023 - "Nanaomycin A, an inhibitor of DNA methyltransferase 3B, which mediates de novo DNA methylation, reportedly induces death in several types of human cancer cells. " 01/01/2023 - "The anti-tumor effect of nanaomycin A on neuroblastoma cell lines was evaluated based on cell viability, DNA methylation levels, apoptosis-related protein expression, and neuronal-associated mRNA expression. " 12/01/2015 - "By utilizing this system, we assessed RG108, SGI-1027 and nanaomycin A, three novel DNA methyltransferase inhibitors that have not been tested in neuroblastoma cell lines so far, for their potential of synergistic anti-tumor activity in combination with doxorubicin. "
3.	Tinea (Ringworm) 07/01/1980 - "[The therapeutic effect of nanaomycin A against experimental Trichophyton mentagrophytes infection in guinea pigs (author's transl)]." 07/01/1980 - "The therapeutic effect of nanaomycin A and siccanin against experimental cutaneous Trichophyton mentagrophytes infection in guinea pigs was investigated. "
4.	Malaria 10/01/1999 - "Namely, the inhibition of in vitro growth of malaria parasite by nanaomycin A or radicicol was reversed by tocopherol, a radical scavenger added to the assay mixture. " 10/01/1999 - "Nanaomycin A inhibited in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM. It was as potent as radicicol and about 1/10 as potent as artemisinin. "
5.	Dehydration (Water Stress) 07/01/1980 - "Nanaomycin B can be converted to nanaomycin A by non-enzymatic dehydration; however, nanaomycin A is rapidly bioconverted to nanaomycin E, which is the major component synthesized by the nanaomycin-producing strain."

Related Drugs and Biologics

1.	Therapeutic Uses
2.	Tocopherols (Tocopherol)
3.	Messenger RNA (mRNA)
4.	Proteins (Proteins, Gene)
5.	Methyltransferases
6.	Doxorubicin (Adriamycin)
7.	DNA (Deoxyribonucleic Acid)
8.	DNA Methyltransferase 3B
9.	SGI-1027
10.	RG108