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senkyunolide I

has antioxidant and anti-migraine activities; isolated from Ligusticum chuanxiong; structure in first source

Networked: 13 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - senkyunolide I: 13

Experts

1.	Feng, Yi: 5 articles (10/2016 - 02/2011)
2.	Liang, Shuang: 5 articles (10/2016 - 02/2011)
3.	Wang, Jia-Feng: 4 articles (01/2022 - 01/2021)
4.	Xie, Jian: 4 articles (01/2022 - 01/2021)
5.	Deng, Xiao-Ming: 3 articles (01/2022 - 01/2021)
6.	Zhao, Zhen-Zhen: 3 articles (10/2021 - 01/2021)
7.	Lin, Xiao: 3 articles (08/2012 - 02/2011)
8.	Xu, De-Sheng: 3 articles (08/2012 - 02/2011)
9.	Yang, Qing: 2 articles (01/2022 - 08/2021)
10.	Li, Peng: 2 articles (10/2021 - 01/2021)

Related Diseases

1.	Thoracic Aortic Aneurysm 10/01/2023 - "Senkyunolide I ameliorates thoracic aortic aneurysm and dissection in mice via inhibiting the oxidative stress and apoptosis of endothelial cells."
2.	Ischemia 08/01/2021 - "Senkyunolide I (SEI)exerts considerable protective effects in various disease models, but its effect on hepatic ischemia-reperfusion (I/R) injury remains unknown. "
3.	Brain Ischemia (Cerebral Ischemia) 10/15/2016 - "Our previous studies showed that senkyunolide I (SEI) exerted anti-inflammatory effects against endotoxin insult in vitro and ameliorative effects on cerebral ischemia/reperfusion (I/R) injury in vivo. " 04/24/2015 - "The aim of the present study was to evaluate the neuroprotective effects of senkyunolide I (SEI) on focal cerebral ischemia-reperfusion (I/R) injury in rats, and investigate the underlying mechanisms. " 04/24/2015 - "Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3."
4.	Reperfusion Injury 01/01/2022 - "Senkyunolide I alleviates renal Ischemia-Reperfusion injury by inhibiting oxidative stress, endoplasmic reticulum stress and apoptosis." 08/01/2021 - "Senkyunolide I attenuates hepatic ischemia/reperfusion injury in mice via anti-oxidative, anti-inflammatory and anti-apoptotic pathways." 01/01/2022 - "Senkyunolide I (SEI), which is the major active phthalide ingredient of Ligusticum striatum DC., is mainly distributed in kidney and has been shown to attenuate ischemia reperfusion injury in liver. " 04/24/2015 - "Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3."
5.	Migraine Disorders (Migraine) 08/01/2012 - "chuanxiong is senkyunolide I (SEI), which shows pharmacological activities in anti-migraine and anti-oxidative damage. " 06/01/2012 - "Comparative pharmacokinetics of senkyunolide I in a rat model of migraine versus normal controls." 02/01/2011 - "Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong." 02/01/2011 - "Therefore, senkyunolide I may be developed as a potential treatment for migraine pain." 02/01/2011 - "To evaluate the analgesic and anti-migraine activities of senkyunolide I from Ligusticum chuanxiong. "

Related Drugs and Biologics

1.	Neuroprotective Agents
2.	Endotoxins
3.	Caspase 3 (Caspase-3)
4.	Luteolin
5.	Glycyrrhizic Acid (Glycyrrhizin)
6.	Acetic Acid (Vinegar)
7.	Brain-Derived Neurotrophic Factor (BDNF)
8.	Tablets
9.	Proteins (Proteins, Gene)
10.	Oxygen (Dioxygen)

Related Therapies and Procedures

1.	Punctures
2.	Ligation