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4- ((1- hydroxy- 2,3- dihydro- 1H,1'H- (2,2- biinden)- 2- yl)methyl)benzoic acid

has anti-inflammatory activity; structure in first source

Also Known As:

6-(methylamino)hexane-1,2,3,4,5-pentanol 4-((1-Hydroxy-2,3-dihydro-1H,1'H-(2,2-biinden)-2-yl)methyl)benzoate; PH46A

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Indenes: 4
        Indans: 7
        4-((1-hydroxy-2,3-dihydro-1H,1'H-(2,2-biinden)-2-yl)methyl)benzoic acid: 4
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Indenes: 4
    - Indans: 7
      - 4-((1-hydroxy-2,3-dihydro-1H,1'H-(2,2-biinden)-2-yl)methyl)benzoic acid: 4

Experts

1.	Frankish, Neil: 4 articles (07/2020 - 06/2012)
2.	Sheridan, Helen: 4 articles (07/2020 - 06/2012)
3.	Zhang, Tao: 3 articles (07/2020 - 12/2017)
4.	Cannon, Aoife: 1 article (07/2020)
5.	Chan, Kit: 1 article (07/2020)
6.	Ece, Abdulilah: 1 article (07/2020)
7.	O'Sullivan, Jacintha: 1 article (07/2020)
8.	Scalabrino, Gaia A: 1 article (02/2020)
9.	Cumming, Graham R: 1 article (12/2017)
10.	Scalabrino, Gaia: 1 article (12/2017)

Related Diseases

1.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 02/05/2020 - "Previously, during its pre-clinical development, in in vivo pre-clinical studies PH46A showed potent anti-inflammatory properties, which can be targeted at a range of diseases, including inflammatory bowel disease (IBD). " 06/14/2012 - "We have evaluated our lead molecule, PH46A, in in vivo models of inflammatory bowel disease (IBD), an area of considerable unmet clinical need; current therapies are often unable to control the course of the disease. "
2.	Colitis 07/01/2020 - "The observed profile of cytokine modulation (IL-6/ TNF-α, IL-8) and inhibition of release of NO and 5-LOX may contribute to the in vivo effects demonstrated by indane dimers and PH46A (1) in murine models of colitis." 06/14/2012 - "6-(methylamino)hexane-1,2,3,4,5-pentanol 4-(((1S,2S)-1-hydroxy-2,3-dihydro-1H,1'H-[2,2-biinden]-2-yl)methyl)benzoate (PH46A): a novel small molecule with efficacy in murine models of colitis."
3.	Autoimmune Diseases (Autoimmune Disease) 12/15/2017 - "PH46A, belonging to a class of 1,2-Indane dimers, has been developed by our research group as a potential therapeutic agent for the treatment of inflammatory and autoimmune diseases. "

Related Drugs and Biologics

1.	Cytokines
2.	methyl benzoate

Related Therapies and Procedures

1.	Therapeutics