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Indans

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Aryl CYCLOPENTANES that are a reduced (protonated) form of INDENES.

Also Known As:

Indanones

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Hydrocarbons: 412
  - Cyclic Hydrocarbons: 3
    - Aromatic Hydrocarbons: 132
      - Aromatic Polycyclic Hydrocarbons: 831
        Indenes: 2
        Indans: 4
        donepezil: 1382
        rasagiline: 243
        5-(2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl)-8-hydroxy-1H-quinolin-2-one: 193
        Aprindine: 107
        delapril: 87
        Phenindione: 59
        Ninhydrin: 49
        2,5-dibromo-2-(beta-naphthyl)indan-1,3-dione: 33
        (N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate: 30
        candoxatril: 30
        SB 209670: 25
        ptaquiloside: 19
        4-amidinoindan-1-one 2'-amidinohydrazone: 17
        flosulide: 15
        indanone: 15
        radolmidine: 13
        SB 217242: 13
        indan: 10
        L 745337: 10
        chlorophacinone: 9
        OPC 14117: 9
        1-aminoindan-1,5-dicarboxylic acid: 8
        (5,6-dimethoxyindan-2-yl)dipropylamine: 7
        (N-propargyl-(3R) and (3S) aminoindan-5-yl)-ethyl methyl carbamate: 6
        1,2-indanedione: 6
        2-(2,4-dimethylphenyl)indan-1,3-dione: 6
        moskene: 6
        2,2-difluorobenzo(1,3)dioxole-5-carboxylic acid indan-2-ylamide: 5
        2-N,N-di-n-propylamino-4,7-dimethoxyindan: 5
        5,6-methylenedioxy-2-aminoindan: 5
        indanocine: 4
        indatraline: 4
        2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol: 3
        3-(2-hydroxymethylindanyl-4-oxy)phenyl-4,4,4-trifluoro-1-sulfonate: 3
        fipamezole: 3
        methindione: 3
        N-(2-indanyl)glycinamide: 3
        nivimedone: 3
        pterosin: 3
        spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one: 3
        5-methylsulfonylamino-6-phenoxy-1-indanone: 2
        camonagrel: 2
        clorindione: 2
        KR 62776: 2
        spiculoic acid A: 2
        (2R)-3-(2-aminomethyl-2,3-dihydro-1H-3a-azacyclopenta(a)inden-8-yl)-4-phenylaminopyrrole-2,5-dione monomethanesulphonate: 1
        (6,7-dimethoxy-2,4-dihydroindeno(1,2-c)pyrazol-3-yl)(3-fluorophenyl)amine: 1
        1,3-indandione: 1
        2-aminoindan: 1
        2-phenoxy-indan-1-one: 1
        4,5,6,7-tetrachloroindan-1,3-dione: 1
        4-benzoyl-1-indancarboxylic acid: 1
        4-bromo-7-hydroxyindan oxime: 1
        5,6-dimethoxyindan-1-acetic acid: 1
        5-acetyl-1,1,2,6-tetramethyl-3-isopropylindane: 1
        6,7-dihydro-1,1,2,3,3-pentamethyl-4-(5H)indanone: 1
        6-methoxyindan-1-acetic acid: 1
        acetyl tert-butyl dimethylindan: 1
        bephedon: 1
        dietor: 1
        indanestrol: 1
        octahydro-exo-4,7-methano-1H-indene: 1
        pindone: 1
        RU 599: 1
        SB 221420-A: 1
        SB-699393: 1
        SDZ PRI 053: 1
        spiro((1,3-diazacyclopent-1-ene)-5 : 2'-(4',5'-dimethylindan)) fumarate: 1
        ((6,7-dichloro-2-(4-fluorophenyl)-2-methyl-1-oxo-5-indanyl)oxy)acetic acid
        (3-(3,4-dichlorophenyl)-4-methoxyindan-1-yl)methylamine
        (3-(3,4-dichlorophenyl)indan-1-yl)-4-methylpiperazine
        (5-methoxy)donepezil
        1,1-bis(4-aminobutyl)-6-benzylindane
        1,1-dibenzyl-6-(4-aminobutyl)indane
        1,1-dimethyl-5-(1-hydroxypropyl)-4,6,7-trimethylindan
        1,1-dimethyl-5-nitro-3-(2-pyridon-1-yl)indan-2-ol
        1,2-indandione
        1,2-indanediol
        1,3-bis(4-iminobenzoic acid)indane
        1,3-dioxoindane-2-carboxylic acid
        1,8 beta-dimethyl-2-ketoperhydrindan-5 beta-methyl- 5 alpha-acetic acid
        1-(4-aminobutyl)-6-benzylindane
        1-(4-fluorobenzyl)-4-((5,6-dimethoxy-1-oxoindan-2-fluoro-2-yl)methyl)piperidine
        1-(4-fluorobenzyl)-4-((5,6-dimethoxy-1-oxoindan-2-yl)methyl)piperidine
        1-aminoindan
        1-benzyl-6-(4-aminobutyl)indane
        1-indanol
        1-methoxy-6-(naphth-2-yl-methoxy)-1-(thiazol-2-yl)indan
        1-methyl-5-phenyl-2,3,4,4a,5,9b-hexahydro-1H-indeno(1,2-b)pyridine
        1-propyl-5-phenyl-2,3,4,4a,5,9b-hexahydro-1H-indeno(1,2-b)pyridine
        2,2-dimethylindan-1,3-dithione
        2,2-dimethylindan-1-one-3-thione
        2,3-dihydro-3-(4'-hydroxyphenyl)-1,1,3-trimethyl-1H-inden-5-ol
        2,3-diphenyl-1-indanone
        2-((1-oxyl-2,2,5,5-tetramethyl-3-pyrrolin-3-yl)methenyl)indane-1,3-dione
        2-(2-(5-bromoindan-1-yl)-3-mercaptopropionylamino)-3-(1H-pyrrolo(2,3-b)pyridin-3-yl)propionic acid
        2-(3,4-dihydro-2H-pyrrolium-1-yl)-3-oxoindan-1-olate
        2-(4,6-difluoro-1-indanylidene)acetamide
        2-(4-chloro-6-fluoro-1-indanylidene)-N-methylacetamide
        2-(4-pyridylmethyl)-1-indanone
Polycyclic Compounds: 56
- Aromatic Polycyclic Hydrocarbons: 831
  - Indenes: 2
    - Indans: 4

Experts

1.	Alcalde, Ermitas: 1 article (10/2008)
2.	López-Pérez, Sara: 1 article (10/2008)
3.	Mercè, Ramon: 1 article (10/2008)
4.	Frigola, Jordi: 1 article (10/2008)
5.	Mesquida, Neus: 1 article (10/2008)
6.	Daggett, Lorrie P: 1 article (03/2005)
7.	Pinkerton, Anthony B: 1 article (03/2005)
8.	Vernier, Jean-Michel: 1 article (03/2005)
9.	Cube, Rowena V: 1 article (03/2005)
10.	Rowe, Blake A: 1 article (03/2005)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 03/15/2005 - "We have identified and synthesized a series of phenyl-tetrazolyl and 4-thiopyridyl indanones as allosteric potentiators of the metabotropic glutamate receptor 2. Structure activity relationship studies directed toward improving the potency and level of potentiation, as well as PK properties, led to the discovery of 28 (EC50=186 nM), which displayed activity in a rodent model for schizophrenia."
2.	Vomiting 04/01/1981 - "Monophenolic (2-(dipropylamino)indans and related compounds have been synthesized and tested for central dopamine-receptor stimulating activity, using biochemical and behavioral tests in rats and emesis tests in dogs. "
3.	Neoplasms (Cancer) 02/02/2000 - "The sensitivity of stationary multidrug-resistant cancer cells to indanocine suggests that indanocine and related indanones be considered as lead compounds for the development of chemotherapeutic strategies for drug-resistant malignancies."
4.	Dehydration (Water Stress) 10/21/2008 - "The first protocol used was a two-step sequence employing a modified Horner-Wadsworth-Emmons reaction, but better results were obtained with a procedure based on the condensation of indanones with the lithium salt of ethyl acetate, followed immediately by dehydration with acid and hydrolysis/isomerization under basic catalysis. "

Related Drugs and Biologics

1.	metabotropic glutamate receptor 2
2.	Dopamine Receptors (Dopamine Receptor)
3.	Lithium
4.	indanocine
5.	ethyl acetate