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N-succinylaspart-1-yl celecoxib

a celecoxib prodrug; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - N-succinylaspart-1-yl celecoxib: 2
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - N-succinylaspart-1-yl celecoxib: 2

Experts

1.	Jung, Yunjin: 2 articles (03/2014 - 05/2012)
2.	Lee, Yonghyun: 2 articles (03/2014 - 05/2012)
3.	Yoon, Jeong-Hyun: 2 articles (03/2014 - 05/2012)
4.	Hong, Sungchae: 1 article (03/2014)
5.	Kim, Wooseong: 1 article (03/2014)
6.	Park, Huijeong: 1 article (03/2014)
7.	Yum, Soohwan: 1 article (03/2014)
8.	Kang, Sookjin: 1 article (05/2012)
9.	Kim, Dae-Duk: 1 article (05/2012)
10.	Kim, Hyunjeong: 1 article (05/2012)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 05/01/2012 - "To develop a colon-specific prodrug of celecoxib, a cyclooxygenase-2 selective inhibitor, which could improve cardiovascular toxicity and therapeutic effectiveness for chemoprevention of colorectal cancer, aspart-1-yl celecoxib (A1C) or aspart-4-yl celecoxib (A4C), succinyl celecoxib (SC), and N-succinylaspart-1-yl celecoxib (SA1C) or N-succinylaspart-4-yl celecoxib (SA4C) were prepared and evaluated as a prodrug with such beneficial properties. "
2.	Colitis 03/05/2014 - "N-succinylaspart-1-yl celecoxib (SA1C), a colon-specific prodrug of celecoxib, was administered orally to rats with experimental colitis, and the anti-colitic effects and a molecular mechanism were investigated and compared to those of conventional celecoxib. "

Related Drugs and Biologics

1.	Prodrugs
2.	Celecoxib (Celebrex)
3.	Cyclooxygenase 2 (Cyclooxygenase-2)

Related Therapies and Procedures

1.	Chemoprevention