Ribosome Inactivating Proteins

N-Glycosidases that remove adenines from RIBOSOMAL RNA, depurinating the conserved alpha-sarcin loop of 28S RIBOSOMAL RNA. They often consist of a toxic A subunit and a binding lectin B subunit. They may be considered as PROTEIN SYNTHESIS INHIBITORS. They are found in many PLANTS and have cytotoxic and antiviral activity.

Also Known As:

Polynucleotide Adenosine Glycosidase; RIP (Ribosome Inactivating Proteins); RNA Glycosylase; rRNA N-Glycosylases; Adenosine Glycosidase, Polynucleotide; Glycosidase, Polynucleotide Adenosine; Glycosylase, RNA; Inactivating Proteins, Ribosome; N-Glycosidase, RNA; N-Glycosylases, rRNA; Proteins, Ribosome Inactivating; RNA N Glycosidase; rRNA N Glycosylases; RIP Ribosome Inactivating Proteins; RNA N-Glycosidase

Pharmalogical Action Categories:

Protein Synthesis Inhibitors

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Glycoside Hydrolases: 871
      - N-Glycosyl Hydrolases: 36
        Ribosome Inactivating Proteins: 51
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Plant Proteins: 334
    - Ribosome Inactivating Proteins: 51

mistletoe lectin III

Bio-Agent Context: Research Results