Plant Lectins

Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. Some carbohydrate-metabolizing proteins (ENZYMES) from PLANTS also bind to carbohydrates, however they are not considered lectins. Many plant lectins change the physiology of the membrane of BLOOD CELLS to cause agglutination, mitosis, or other biochemical changes. They may play a role in plant defense mechanisms.

Also Known As:

Networked: 93 relevant articles (0 outcomes, 10 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Balzarini, Jan: 4 articles (09/2007 - 10/2004)
2.	Peumans, Willy: 4 articles (09/2007 - 10/2004)
3.	Van Damme, Els: 4 articles (09/2007 - 10/2004)
4.	Gabius, Hans-Joachim: 3 articles (08/2012 - 02/2008)
5.	André, Sabine: 3 articles (08/2012 - 02/2008)
6.	Liu, Bo: 3 articles (10/2011 - 01/2010)
7.	Schols, Dominique: 3 articles (05/2005 - 10/2004)
8.	Hatse, Sigrid: 3 articles (05/2005 - 10/2004)
9.	De Clercq, Erik: 3 articles (05/2005 - 10/2004)
10.	Cavada, Benildo Sousa: 2 articles (02/2015 - 01/2010)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2014 - "Plant lectins have attracted great interest in cancer studies due to their antitumor activities. " 10/01/2011 - "Moreover, we summarize the possible anti-cancer therapeutic implications of plant lectins such as ConA, Phaseolus vulgaris lectin (PHA) and MLs that have been utilized at different stages of preclinical and clinical trials. " 02/01/2015 - "Thus, here we summarize these findings on pathway- involved plant lectins, to provide a comprehensive perspective for further elucidating their potential role as novel anti-cancer drugs, with respect to both apoptosis and autophagy in cancer pathogenesis, and future therapy. " 02/01/2015 - "Plant lectins may have a role as potential new anti-tumour agents in cancer drug discovery. " 02/01/2015 - "It has been widely accepted that plant lectins affect both apoptosis and autophagy by modulating representative signalling pathways involved in Bcl-2 family, caspase family, p53, PI3K/Akt, ERK, BNIP3, Ras-Raf and ATG families, in cancer. "
2.	Infection 10/01/2013 - "The present review comprises four main themes: (1) an overview of plant lectins that exert immunomodulatory effects and the mechanisms accounting for these activities; (2) general characteristics of the immunomodulatory lectin ArtinM from the seeds of Artocarpus heterophyllus; (3) activation of innate immunity cells by ArtinM and consequent induction of Th1 immunity; (4) resistance conferred by ArtinM administration in infections with intracellular pathogens, such as Leishmania (Leishmania) major, Leishmania (Leishmania) amazonensis, and Paracoccidioides brasiliensis. " 11/01/2011 - "Several plant lectins and the small molecular weight compound Pladimicin-S showed potent inhibition of cellular infection by four DENV serotypes." 01/01/2011 - "However, their distribution did not correlate with pattern of virus infection indicating that staining by plant lectins is not a reliable indicator for the presence of cellular receptors for influenza viruses. " 12/01/1995 - "It is possible that these effects of the infection on the metabolism and morphology of the small bowel, which strongly resembled the changes induced by some plant lectins, may facilitate the colonisation and invasion of the gut by Salmonellae." 05/24/1972 - "Agglutination of normal cells by plant lectins following infection with nononcogenic viruses."
3.	Breast Neoplasms (Breast Cancer) 03/01/2003 - "These findings would argue for a protective effect of these plant lectins for breast cancer." 12/01/2010 - "The present study tested the hypothesis that the production of vascular endothelial growth factor C (VEGF-C), a key lymphangiogenic factor, by human breast cancer cells can be stimulated by human lectins, using plant lectins as controls. " 12/01/2010 - "Differential stimulation of VEGF-C production by adhesion/growth-regulatory galectins and plant lectins in human breast cancer cells." 12/01/2010 - "The effects of human galectins and five plant lectins reacting with distinct determinants of N- and O-glycans on the accumulation of VEGF-C in serum-free cell culture media of human breast cancer cells endowed with high (MDA-MB-231) and low (MCF7, T-47D, and SK-BR-3) VEGF-C-producing abilities were examined. "
4.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 05/01/2003 - "Over the years, the study of exfoliated colonocytes has provided striking new insights into the biology of colon cancer and inflammatory bowel disease, including detection of p53 gene mutations, reverse transcriptase polymerase chain reaction amplification, and identification of CD44 splice variants, neoplasia-associated specific binding of plant lectins, and expression of COX-2, the inducible form of cyclooxygenase. "
5.	Sarcoma (Soft Tissue Sarcoma) 01/01/1999 - "The aim of our study is to investigate the in vitro effects of plant lectins, galectins and neoglycoconjugates on the proliferation of three human sarcoma cell lines. "

Related Drugs and Biologics

1.	Mannose (D-Mannose)
2.	Lectins
3.	Galectins (Galectin)
4.	Polysaccharides
5.	Concanavalin A
6.	Epitopes
7.	Vascular Endothelial Growth Factor C
8.	Peanut Agglutinin
9.	RNA-Directed DNA Polymerase (Reverse Transcriptase)
10.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)

Related Therapies and Procedures

1.	Therapeutics