Type 2 Ribosome Inactivating Proteins

Ribosome inactivating proteins consisting of two polypeptide chains, the toxic A subunit and a lectin B subunit, linked by disulfide bridges. The lectin portion binds to cell surfaces and facilitates transport into the ENDOPLASMIC RETICULUM.

Also Known As:

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ferreras, J Miguel: 1 article (10/2002)
2.	Girbés, Tomás: 1 article (10/2002)
3.	Jiménez, Pilar: 1 article (10/2002)
4.	Benítez, Jorge: 1 article (10/2002)
5.	Citores, Lucía: 1 article (10/2002)
6.	Muñoz, Raquel: 1 article (10/2002)
7.	Ferreras, J M: 1 article (06/2001)
8.	Muñoz, R: 1 article (06/2001)
9.	Arias, Y: 1 article (06/2001)
10.	Girbés, T: 1 article (06/2001)

Related Diseases

1.

Neoplasms (Cancer) 10/08/2002 - "Nigrin b and ebulin l are type 2 ribosome-inactivating proteins (RIPs) with 10(4) times less cellular and in vivo toxicity than ricin that are currently being considered for the construction of anti-cancer conjugates. " 10/08/2002 - "Targeting cancer cells with transferrin conjugates containing the non-toxic type 2 ribosome-inactivating proteins nigrin b or ebulin l." 06/26/2001 - "The cytotoxicity of the type 2 ribosome-inactivating proteins (RIPs) ricin and nigrin b was determined in a variety of cancer cells. "

Related Drugs and Biologics

1.	Streptonigrin (Nigrin)
2.	Ricin
3.	Transferrin (beta 2 Transferrin)