Arachidonate 12-Lipoxygenase

An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.

Also Known As:

12 Lipoxygenase; Arachidonate 12 Lipoxygenase; Arachidonic Acid 12-Lipoxygenase; 12-Lipoxygenase, Arachidonate; 12-Lipoxygenase, Arachidonic Acid; Arachidonic Acid 12 Lipoxygenase; 12-Lipoxygenase; Arachidonate:oxygen 12-oxidoreductase

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Dioxygenases: 495
        Lipoxygenases: 264
        Arachidonate Lipoxygenases: 16
        Arachidonate 12-Lipoxygenase: 269
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Metalloproteins: 164
    - Iron-Binding Proteins: 172
      - Nonheme Iron Proteins
        Lipoxygenases: 264
        Arachidonate Lipoxygenases: 16
        Arachidonate 12-Lipoxygenase: 269

12-15-lipoxygenase

Bio-Agent Context: Research Results