RU 58841

a topically active non-steroidal antiandrogen; structure given in first source

Also Known As:

4-(4,4-dimethyl-2,5-dioxo-3-(4-hydroxybutyl)-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile; Benzonitrile, 4-(3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl)-2-(trifluoromethyl)-; RU-58841; RU58841

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - RU 58841: 6
Organic Chemicals: 133
- Nitriles: 227
  - RU 58841: 6

Related Diseases

1.	Acne Vulgaris 06/12/1995 - "The potent localized inhibition of sebaceous glands by RU 58841 demonstrates the excellent potential of this compound as a topical drug for the treatment of acne and other androgen-mediated disorders." 08/01/1998 - "Together our results suggest that RU58841 may have potent antagonism to the wt AR and could be considered as a topically applied active anti-androgen for the treatment of androgen-dependent skin disorders, such as acne, androgenetic alopecia, and hirsutism." 01/01/1994 - "These results suggest that RU 58841 might useful for the topical treatment of androgen-dependent skin disorders such as acne, androgenetic alopecia and hirsutism." 01/01/1994 - "RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism." 01/01/1997 - "Using this model for human acne, we examined the effects of inhibitors of human steroid 5 alpha-reductase isozymes, type I (MK 386) and type II (finasteride), and an androgen receptor blocker (RU58841) on regression of glandular and ductal hyperplasia. "
2.	Alopecia (Baldness) 08/01/1998 - "However, RU58841, on topical application, revealed a potent increase in density, thickening, and length of hair in the macaque model of androgenetic alopecia, whereas no systemic effects were detected. " 08/01/1998 - "Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques." 11/01/1997 - "Recycling and increased LHGR indicate a positive action for RU58841 on human hair growth from balding samples grafted on to testosterone-conditioned nude mice, and encourage a clinical trial to evaluate its potential in the treatment of androgen-dependent alopecia." 08/01/1998 - "Together our results suggest that RU58841 may have potent antagonism to the wt AR and could be considered as a topically applied active anti-androgen for the treatment of androgen-dependent skin disorders, such as acne, androgenetic alopecia, and hirsutism." 01/01/1994 - "These results suggest that RU 58841 might useful for the topical treatment of androgen-dependent skin disorders such as acne, androgenetic alopecia and hirsutism."
3.	Hirsutism 08/01/1998 - "Together our results suggest that RU58841 may have potent antagonism to the wt AR and could be considered as a topically applied active anti-androgen for the treatment of androgen-dependent skin disorders, such as acne, androgenetic alopecia, and hirsutism." 01/01/1994 - "These results suggest that RU 58841 might useful for the topical treatment of androgen-dependent skin disorders such as acne, androgenetic alopecia and hirsutism." 01/01/1994 - "RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism."
4.	Skin Diseases (Skin Disease) 08/01/1998 - "From this result, topical application of RU58841, which is considered to be a potential therapy for skin diseases, may induce systemic side effects. "
5.	Prostatic Neoplasms (Prostate Cancer) 08/01/1998 - "The effect of androgen receptor transcriptional activation by RU58841, a nonsteroidal anti-androgen, was studied in the human prostate cancer PC3 cell line by cotransfection with wild-type androgen receptor (wt AR) and an androgen-responsive reporter (MMTV-ARE-CAT) construct. "

Related Drugs and Biologics

1.	Androgens
2.	Androgen Receptors (Androgen Receptor)
3.	Androgen Antagonists (Antiandrogens)
4.	Finasteride (Propecia)
5.	3-Oxo-5-alpha-Steroid 4-Dehydrogenase (Testosterone 5 alpha Reductase)
6.	Testosterone (Sustanon)
7.	Solutions
8.	Liposomes (Liposome)
9.	Isoenzymes
10.	4,7beta-dimethyl-4-azacholestan-3-one

Related Therapies and Procedures

1.	Therapeutics