antithrombin Cambridge II

abnormal antithrombin; Ala replaced by Ser in position 384; causes minor but consistent decrease in heparin-induced thrombin inhibition

Also Known As:

Antithrombin (human protein moiety reduced), 384-L-serine-

Networked: 7 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fontcuberta, Jordi: 3 articles (03/2009 - 05/2007)
2.	Corral, Javier: 2 articles (03/2009 - 05/2007)
3.	Vicente, Vicente: 2 articles (03/2009 - 05/2007)
4.	Deng, Ming-yang: 1 article (09/2010)
5.	Qing, Zi-Ju: 1 article (09/2010)
6.	Shu, Chang: 1 article (09/2010)
7.	Tan, Li-ming: 1 article (09/2010)
8.	Tang, Mei-qing: 1 article (09/2010)
9.	Tang, Xiang-qi: 1 article (09/2010)
10.	Tang, Yang-ming: 1 article (09/2010)

Related Diseases

1.	Activated Protein C Resistance (APC Resistance) 02/01/2005 - "Antithrombin (AT) assays were shown to vary in their sensitivity to different molecular defects in the antithrombin gene; 77% of centers employing human thrombin-based activity assays reported a normal AT level in a patient with antithrombin Cambridge II. Sensitivity of the APC resistance test in the absence of factor V-deficient plasma was shown to be improved through normalization of results, and errors in the genetic diagnosis of factor V Leiden and the P20210A prothrombin gene mutation are described. "
2.	Thrombosis (Thrombus) 10/01/2007 - "Antithrombin Cambridge II (A384S): prevalence in patients of the Paris Thrombosis Study (PATHROS)." 03/01/2009 - "Antithrombin Cambridge II (A384S) supports a role for antithrombin deficiency in arterial thrombosis."
3.	Myocardial Infarction 03/01/2009 - "In this study we evaluated the role in myocardial infarction (MI) of a relatively common mutation affecting antithrombin gene (A384S: Antithrombin Cambridge II) that has functional features that may impair the right control of thrombogenic events caused by injury to the vascular wall. "
4.	Venous Thrombosis (Deep-Vein Thrombosis) 02/01/2008 - "Antithrombin Cambridge II mutation as a risk factor to develop cerebral venous thrombosis." 05/15/2007 - "Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis." 11/01/2008 - "Relation between the antithrombin Cambridge II mutation, the risk of venous thrombosis, and the endogenous thrombin generation." 09/01/2010 - "Antithrombin Cambridge II(A384S) mutation frequency and antithrombin activity levels in 120 of deep venous thrombosis and 150 of cerebral infarction patients in a single center in Southern China."
5.	Thrombophilia 09/01/2010 - "These results suggest that antithrombin Cambridge II mutation has a racial difference, and may not be a valuable risk factor of thrombophilia in Asian population, and antithrombin deficiency remains a major genetic risk factor for DVT patients in China."

Related Drugs and Biologics

1.	Antithrombins
2.	Thrombin
3.	Prothrombin (Factor II)
4.	Factor V (Coagulation Factor V)
5.	factor V Leiden