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apocodeine
monomethyl ether of apomorphine; used as expectorant, hypnotic, & cathartic; RN refers to (R)-isomer; structure
Also Known As:
apocodeine hydrochloride, (R)-isomer; apocodeine oxalate, (R)-isomer
Networked:
4
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Alkaloids: 5398
Benzylisoquinolines: 151
Aporphines: 10
Apomorphine: 2080
apocodeine: 4
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Isoquinolines: 34
Benzylisoquinolines: 151
Aporphines: 10
Apomorphine: 2080
apocodeine: 4
4 or More Rings Heterocyclic Compounds
Aporphines: 10
Apomorphine: 2080
apocodeine: 4
Related Diseases
1.
Parkinson Disease (Parkinson's Disease)
05/01/1998 - "
The pharmacokinetics and metabolism of R-apomorphine were determined in 10 patients with idiopathic Parkinson's disease after intravenous infusion of 30 micrograms.kg-1 in 15 min. Specifically, emphasis was on enantiomeric interconversion into S-apomorphine and on the formation of apocodeine and isoapocodeine, since these metabolites may interfere with the pharmacodynamics of R-apomorphine.
"
05/01/1998 - "
The findings of this study show that on intravenous administration, S-apomorphine and the metabolites apocodeine and isoapocodeine are unlikely to interfere with the pharmacologic actions of R-apomorphine in patients with idiopathic Parkinson's disease.
"
11/21/1997 - "
Assay of R-apomorphine, S-apomorphine, apocodeine, isoapocodeine and their glucuronide and sulfate conjugates in plasma and urine of patients with Parkinson's disease.
"
2.
Chronic Bronchitis
02/28/1891 - "
On the Action of Apomorphine and Apocodeine, with Reference to their Value as Expectorants in the Treatment of Chronic Bronchitis.
"
3.
Paralysis (Palsy)
11/02/1903 - "
The paralysis of nerve cells and nerve endings with special reference to the alkaloid apocodeine.
"
Related Drugs and Biologics
1.
Apomorphine
2.
isoapocodeine
3.
Pharmacologic Actions
4.
Glucuronides
5.
Sulfates (Sulfates, Inorganic)
6.
Expectorants (Mucolytics)
7.
Alkaloids
Related Therapies and Procedures
1.
Intravenous Administration
2.
Intravenous Infusions