Chronic Bronchitis

A subcategory of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. The disease is characterized by hypersecretion of mucus accompanied by a chronic (more than 3 months in 2 consecutive years) productive cough. Infectious agents are a major cause of chronic bronchitis.

Also Known As:

Networked: 2889 relevant articles (205 outcomes, 505 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pneumonia (Pneumonitis)
2.	Asthma (Bronchial Asthma)
3.	Chronic Obstructive Pulmonary Disease (COPD)
4.	Infection
5.	Sinusitis

Experts

1.	Miravitlles, Marc: 10 articles (06/2013 - 02/2005)
2.	Anzueto, Antonio: 8 articles (08/2015 - 06/2002)
3.	Rabe, Klaus F: 7 articles (08/2015 - 10/2010)
4.	Martinez, Fernando J: 7 articles (03/2015 - 01/2004)
5.	Blasi, F: 7 articles (10/2013 - 01/2001)
6.	Zhanel, George G: 6 articles (10/2014 - 01/2002)
7.	Blasi, Francesco: 6 articles (01/2013 - 10/2005)
8.	Fabbri, L M: 6 articles (09/2012 - 07/2001)
9.	Sethi, Sanjay: 6 articles (07/2012 - 10/2003)
10.	Wilson, Robert: 5 articles (11/2012 - 04/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronic Bronchitis:

1.	Amoxicillin (Wymox)FDA LinkGeneric 02/01/1988 - "A randomized double blind trial comparing two amoxycillin regimens in the treatment of acute exacerbations of chronic bronchitis was performed. " 02/01/1988 - "A randomized double blind controlled trial comparing two amoxycillin regimens in the treatment of acute exacerbations of chronic bronchitis." 03/01/1992 - "Amoxicillin in treatment of acute uncomplicated exacerbations of chronic bronchitis. " 02/01/1988 - "It is concluded that short course high dose amoxycillin may be as effective as conventional course amoxycillin in the treatment of acute exacerbations of chronic bronchitis." 03/01/1987 - "Amoxycillin is a standard therapy in the treatment of patients with acute exacerbations of chronic bronchitis. "
2.	Clarithromycin (Biaxin)FDA LinkGeneric 03/01/1992 - "The new macrolide, clarithromycin, appears to be effective and well-tolerated in the treatment of acute exacerbation of chronic bronchitis." 02/01/2005 - "Comparative efficacy of once daily, 5-day short-course therapy with clarithromycin extended-release versus twice daily, 7-day therapy with clarithromycin immediate-release in acute bacterial exacerbation of chronic bronchitis." 03/01/2007 - "Outpatients with acute bacterial exacerbation of chronic bronchitis were treated with clarithromycin 250 mg twice daily or clarithromycin in modified release formulation 500 mg once daily, for 7 days in a prospective, randomized, single-centre study. " 02/01/2005 - "The objective of this study was to compare the efficacy, tolerability, and safety of two clarithromycin regimens, extended-release (ER) 1000 mg once daily for 5 days and immediate-release (IR) 500 mg twice daily for 7 days, in the treatment of acute bacterial exacerbation of chronic bronchitis (ABECB). " 01/01/2003 - "Two randomized trials in patients with acute exacerbations of chronic bronchitis (AECB) showed that a 7-day course of clarithromycin extended-release 1000 mg once daily produced clinical cure rates of 83% and 85% and bacteriologic cure rates of 86% and 92% at the test-of-cure study visit. "
3.	Anti-Bacterial Agents (Antibiotics)IBA 03/01/1998 - "A recent meta-analysis of all randomized, placebo-controlled trials of patients treated with antibiotics for acute exacerbations of chronic bronchitis concluded that a small but statistically significant improvement could be expected in antibiotic-treated patients. " 01/01/2007 - "As the research undertaken to date on the efficacy of the new antibiotics in the treatment of exacerbations of chronic bronchitis has taken the form of trials designed to demonstrate equivalence, we have no data on the advantages associated with the use of these new drugs with greater bactericidal activity. " 11/01/2008 - "Is a short course of antibiotics effective for acute exacerbation of chronic bronchitis?" 01/01/1987 - "Acute exacerbations of chronic bronchitis are always treated with antibiotics effective against H. " 09/01/1999 - "The data suggest that focused antibacterial studies may be helpful in evaluating antibiotics in acute exacerbation of chronic bronchitis."
4.	Ciprofloxacin (Cipro)FDA LinkGeneric 01/01/1998 - "A 1-year community-based health economic study of ciprofloxacin vs usual antibiotic treatment in acute exacerbations of chronic bronchitis: the Canadian Ciprofloxacin Health Economic Study Group." 11/01/1999 - "To undertake a 1-year prospective economic evaluation of ciprofloxacin compared with usual antibacterial care (any antibacterial other than a quinolone) for the treatment of acute exacerbations of chronic bronchitis (AECB) in adults presenting with a type I or type II AECB. " 11/01/1999 - "Economic evaluation of ciprofloxacin compared with usual antibacterial care for the treatment of acute exacerbations of chronic bronchitis in patients followed for 1 year." 09/01/1998 - "Etiology, susceptibility, and treatment of acute bacterial exacerbations of complicated chronic bronchitis in the primary care setting: ciprofloxacin 750 mg b.i.d. " 03/28/1998 - "[The role of ciprofloxacin in the treatment of chronic bronchitis]."
5.	Ofloxacin (Levofloxacin)FDA LinkGeneric 12/01/2001 - "A randomized, double-blind, multicentre study was conducted in adult patients with acute exacerbation of chronic bronchitis (AECB), to compare the efficacy of a 5-day course of levofloxacin 500 mg once daily, with the standard 7-day regimen at the same dose. " 11/01/2004 - "[Efficacy of levofloxacin in the treatment of acute exacerbation of chronic bronchitis in patients with risk factors]." 05/01/2015 - "Levofloxacin concentrations in plasma and ELF were collected from two previous studies involving 18 infected patients with acute exacerbations of chronic bronchitis and 15 uninfected elderly patients undergoing diagnostic bronchoscopy. " 02/01/2012 - "The purpose of this study was to determine the intrapulmonary profile of high-dose (750 mg) levofloxacin in patients during an acute exacerbation of chronic bronchitis (AECB). " 10/01/2005 - "In this study we examined the relationship between the in vitro bacterial susceptibility to levofloxacin, the achieved levofloxacin serum and sputum concentrations, and the in vivo bacterial eradication in patients with acute exacerbations of chronic bronchitis. "
6.	moxifloxacin (Avelox)FDA Link 01/01/2007 - "[Clinical efficacy of moxifloxacin in the treatment of exacerbations of chronic bronchitis: a systematic review and meta-analysis]." 09/01/2001 - "The efficacy of moxifloxacin in acute exacerbations of chronic bronchitis: a Spanish physician and patient experience." 01/01/2013 - "AVANTI (AVelox® in Acute Exacerbations of chroNic bronchiTIs) was a prospective, observational study conducted in eight Eastern European countries in patients > 35 years with AECB/AECOPD to whom moxifloxacin was prescribed. " 01/01/2013 - "Efficacy and safety of moxifloxacin in acute exacerbations of chronic bronchitis: a prospective, multicenter, observational study (AVANTI)." 07/01/2012 - "The Moxifloxacin in Acute Exacerbations of Chronic Bronchitis TriaL (MAESTRAL) was a multiregional, randomised, double-blind non-inferiority outpatient study. "
7.	Ipratropium (Ipratropium Bromide)FDA LinkGeneric 01/01/1998 - "The highest atrovent efficacy was recorded in patients with chronic bronchitis of smokers and chronic bronchitis in tracheobronchial diskinesia. " 01/29/1996 - "Ipratropium bromide has become primary therapy for the treatment of adults with chronic bronchitis, but its use in children has been limited. " 05/01/1994 - "Whether nebulized ipratropium bromide is of benefit to mechanically ventilated patients with chronic bronchitis is not well defined. " 07/01/1985 - "Effect of ipratropium bromide (atrovent) inhalation in chronic bronchitis." 01/01/1985 - "We conclude that ipratropium bromide should be inhaled in high doses (0.2 mg) by hypersecretory patients with chronic bronchitis to improve mucociliary transport."
8.	Erythromycin (Erycette)FDA LinkGeneric 01/01/1988 - "Serum, sputum and bronchial concentrations of erythromycin in chronic bronchitis after single and multiple treatments with either propionate-N-acetylcysteinate or stearate erythromycin." 06/01/1980 - "Plasma and sputum erythromycin concentrations in chronic bronchitis." 01/01/1980 - "A cohort of patients with chronic bronchitis were invited to take erythromycin prophylactically to reduce the number of exacerbations of their disease. " 01/01/1980 - "The use of erythromycin as prophylaxis in chronic bronchitis: a cohort study from general practice." 06/05/1971 - "[Erythromycin in chronic bronchitis]."
9.	dirithromycin (Dynabac)FDA Link 03/01/1993 - "Clinical efficacy of dirithromycin in acute exacerbations of chronic bronchitis." 01/01/1998 - "Since a high tissue penetration of dirithromycin (D) has been assessed in early studies, the aims of this study were to determine D concentrations in bronchial mucosa and secretions in patients suffering from an acute exacerbation of chronic bronchitis (AECB), to compare intra-individual bronchial mucosa and secretion concentrations and to relate bronchial concentrations of D and clinical efficacy. " 08/01/1997 - "This study shows that a 5-day dirithromycin therapy provides a convenient and efficient dosage regimen in acute exacerbation of chronic bronchitis. " 12/01/1994 - "The aim of this study was to evaluate the concentrations of dirithromycin, a new macrolide antibiotic, in bronchial secretions (BS), bronchial mucosa (BM), epithelial lining fluid (ELF) and serum in 25 patients with acute exacerbation of chronic bronchitis after a 5-day, once-daily, dirithromycin regimen. " 12/01/1994 - "Pulmonary penetration of dirithromycin in patients suffering from acute exacerbation of chronic bronchitis."
10.	lomefloxacin (Maxaquin)FDA Link 04/06/1992 - "The results of this study demonstrate that once-daily treatment with 400 mg lomefloxacin is as effective as twice-daily dosing with 400 mg in patients with acute bacterial exacerbations of chronic bronchitis." 12/01/1992 - "In conclusion, once-daily lomefloxacin is a safe and effective treatment for acute exacerbations of chronic bronchitis caused by Gram-negative pathogens." 01/01/1998 - "[Efficacy of lomefloxacin in treatment of patients with chronic bronchitis]." 04/06/1992 - "This study was designed to assess whether a dose response exists for 400 mg lomefloxacin given once daily or twice daily for 10 days in the treatment of acute bacterial exacerbations of chronic bronchitis of gram-negative etiology. " 12/01/2001 - "Lomefloxacin is a difluorinated quinolone with excellent activity against a wide range of pathogens including those responsible for acute exacerbations of chronic bronchitis (AECB). "

Therapies and Procedures

1.	Nebulizers and Vaporizers (Inhaler) 10/01/1988 - "Nebuhaler or nebulizer for high dose bronchodilator therapy in chronic bronchitis: a comparison." 07/01/1974 - "Cigarette smokers' chronic bronchitis: inhalers and non-inhalers compared." 06/01/1992 - "This study stresses the importance of regular instruction in inhaler technique and proper information about prophylactic steroid treatment by the general practitioner during the treatment of asthma and chronic bronchitis." 08/01/2002 - "One hundred seventy-two patients (117 men [68%] and 55 women [32%]), who were > 40 years of age, had not been known previously by the participating physicians, and met at least one of the following criteria: smokers of > 20 pack-years; patients who had received a diagnosis of or had self-reported COPD (or chronic bronchitis or emphysema); patients who had received inhaler bronchodilator treatment for > 6 months; or patients with any degree of dyspnea. " 10/01/1988 - "We have compared the clinical efficacy of high dose terbutaline sulphate (10 mg four times daily) delivered by either a Nebuhaler or jet nebulizer in 13 patients with chronic bronchitis in a 2-week, open, crossover study. "
2.	Drug Therapy (Chemotherapy) 01/21/1995 - "Future trials of antibacterial chemotherapy for acute bacterial exacerbations of chronic bronchitis should incorporate such criteria so that real differences between existing and improved compounds can be assessed." 01/01/1999 - "Assessment of efficacy of combined treatment of chronic bronchitis (CB) in subjects exposed to radiation after the Chernobyl accident including nonpharmacological (NP) modalities vs conventional chemotherapy (CT). " 03/01/1972 - "2. Studies on the ambulatory drug therapy of chronic bronchitis with special reference to central therapy recommendations and to chemotherapeutical aspects]." 04/01/1968 - "A five year study of bacteriology and prophylactic chemotherapy in patients with chronic bronchitis." 05/28/1966 - "A report to the Medical Research Council by their working party on trials of chemotherapy in early chronic bronchitis."
3.	Radiotherapy 01/01/2015 - "targeted therapy and radiotherapy) and chronic bronchitis were associated with overall survival. " 01/01/2015 - "targeted therapy and radiotherapy), LYR, a decreasing tendency of LYR and chronic bronchitis were individually associated with overall survival by Cox regression analysis. " 06/27/1964 - "CHRONIC BRONCHITIS AND RADIOTHERAPY OF THE LUNG." 06/27/1964 - "CHRONIC BRONCHITIS AND RADIOTHERAPY OF THE LUNG." 06/06/1964 - "CHRONIC BRONCHITIS AND RADIOTHERAPY OF THE LUNG."
4.	Intermittent Positive-Pressure Breathing 03/01/1977 - "Pulmonary aerosol deposition in chronic bronchitis: intermittent positive pressure breathing versus quiet breathing." 01/01/1991 - "The literature concerning traditional chest physiotherapy (postural drainage, percussion, vibration, breathing exercises), treatments with masks (CPAP, IPPB, RMT, PEP, PEEP) and general physical training in the treatment of chronic bronchitis is reviewed. " 10/29/1990 - "The literature concerning traditional chest physiotherapy (postural drainage, percussion, vibration, breathing exercises), treatments with masks (CPAP, IPPB, RMT, PEP, PEEP) and general physical training in the treatment of chronic bronchitis is reviewed. " 05/01/1982 - "IPPB probably does not improve delivery of bronchodilators and is of no benefit (and possible harmful) in the long term treatment of chronic bronchitis. " 03/01/1979 - "Fourteen patients with acute exacerbations of chronic bronchitis and hypercapnia received two treatment periods with Intermittent Positive Pressure Breathing, the ventilator being driven by gas containing about 24% or about 45% oxygen. "
5.	Steam Bath (Sauna) 10/01/1991 - "The effect of sauna on tracheobronchial clearance was studied in five male patients with chronic bronchitis by a radioaerosol technique. " 10/01/1991 - "Measurement of tracheobronchial clearance after sauna in subjects with chronic bronchitis." 07/15/1973 - "[Sauna in the ambulatory treatment of patients with chronic bronchitis syndrome]." 01/01/1984 - "[Pathogenetic basis of a regimen of therapeutic hyperthermia in a sauna for chronic bronchitis patients]." 03/01/1983 - "[Cardiorespiratory reactions of chronic bronchitis patients to a single exposure to therapeutic hyperthermia in a sauna]."