Isoquinolines

A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)

Networked: 16 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cushman, Mark: 1 article (03/2012)
2.	Conda-Sheridan, Martin: 1 article (03/2012)
3.	Park, Eun-Jung: 1 article (03/2012)
4.	Kiselev, Evgeny: 1 article (03/2012)
5.	Pezzuto, John M: 1 article (03/2012)
6.	Gelb, Michael H: 1 article (12/2009)
7.	Buckner, Frederick S: 1 article (12/2009)
8.	Arif, Jenifer: 1 article (12/2009)
9.	Chennamaneni, Naveen Kumar: 1 article (12/2009)
10.	Deng, Yu-Lin: 1 article (06/2008)

Related Diseases

1.	Chagas Disease (American Trypanosomiasis) 12/01/2009 - "These isoquinolines represent new leads for the development of drugs to treat Chagas disease." 01/01/1999 - "cruzi and in experimental Chagas disease (murine model): alkyllysophospholipids; 5-amino-imidazole-4-carboxamides; bisbenzyl-isoquinolines; cruzipain (crucein) inhibitors; Gossipol; phenothiazines; d) drugs effective in vitro without other reported effects, acridines, actinomycin D, Crystal Violet (gentian violet), diterpenes (Mikania obtusata); N,N'-dimethyl-2-propen-1-amine, epoxidienthiol carbamates, Fe-chelators, guanyl hydrazones, o-naphthoquinones (beta-lapachone); quinoids (miconidine; tingenone); Olivacine, phenazine methosulfate, phenoxi-phenoxyl drugs, Proadifen, pyridinium azolate betaines, sesquiterpenes (Lychophora sp), sesquiterpene lactones, tetrahydrocarbazoles, DL-alpha-trifluoromethylarginine, triphenylmetane dyes. "
2.	Medulloblastoma 10/20/1998 - "Compounds 6a-f were tested in vitro against human medulloblastoma D283 Med and glioblastoma A-172 and T98G cell lines and showed improved cytotoxicity compared to the corresponding, less rigid pyrido[1,2-b]isoquinolines 1."
3.	Glioblastoma (Glioblastoma Multiforme) 10/20/1998 - "Compounds 6a-f were tested in vitro against human medulloblastoma D283 Med and glioblastoma A-172 and T98G cell lines and showed improved cytotoxicity compared to the corresponding, less rigid pyrido[1,2-b]isoquinolines 1."
4.	Myeloid Leukemia (Leukemia, Myelocytic) 02/01/2008 - "In this study, we demonstrated that the indeno[1,2-c]isoquinolines markedly enhanced differentiation of human myeloid leukemia HL-60 and NB4 cells when simultaneously combined with a low dose of ATRA. " 02/01/2008 - "Indeno[1,2-c]isoquinolines as enhancing agents on all-trans retinoic acid-mediated differentiation of human myeloid leukemia cells."
5.	Parkinson Disease (Parkinson's Disease) 06/01/2008 - "The catechol isoquinolines detected in cells may be involved in the pathogenesis of Parkinson's disease as potential neurotoxins." 11/01/2006 - "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin is a chemical inducer of Parkinson's disease (PD) whereas N-methylated beta-carbolines and isoquinolines are naturally occurring analogues of MPTP involved in PD. "

Related Drugs and Biologics

1.	Sesquiterpenes
2.	Proadifen
3.	Phenothiazines
4.	Naphthoquinones
5.	Methylphenazonium Methosulfate
6.	Lactones
7.	Hydrazones
8.	Gentian Violet (Violet, Crystal)
9.	Coloring Agents (Dyes)
10.	Diterpenes