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6-O-desulfated heparin

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Glycosaminoglycans: 5640
    - Heparin: 24996
      - 6-O-desulfated heparin: 2

Experts

1.	Chen, Jinghua: 1 article (09/2021)
2.	Deng, Chao: 1 article (09/2021)
3.	Hu, Yiwei: 1 article (09/2021)
4.	Kang, Mingzhu: 1 article (09/2021)
5.	Teng, Liping: 1 article (09/2021)
6.	Wang, Danhui: 1 article (09/2021)
7.	Wu, Xiaotao: 1 article (09/2021)
8.	Zhang, Yan: 1 article (09/2021)
9.	Zhu, Min: 1 article (09/2021)

Related Diseases

1.	Myocardial Ischemia (Ischemic Heart Diseases) 12/01/2022 - "6-O-desulfated heparin attenuates myocardial ischemia/reperfusion injury in mice through the regulation of miR-199a-5p/klotho axis." 12/01/2022 - "Administration of 6-O-desulfated heparin significantly reduced creatine kinase activity, myocardial infarct size and cell apoptosis in mice subjected to 30 min of myocardial ischemia following 2 h of reperfusion, accompanied by a reverse in miR-199a-5p elevation, klotho downregulation and reactive oxygen species (ROS) accumulation. "
2.	Reperfusion Injury 12/01/2022 - "6-O-desulfated heparin attenuates myocardial ischemia/reperfusion injury in mice through the regulation of miR-199a-5p/klotho axis."
3.	Neoplasms (Cancer) 09/30/2021 - "The findings indicated the reduced tumor-derived exosome secretion and protein cargo as reflected by lower levels of CD63, TSG101, heparinase and IL-6 in exosomes derived from heparin-induced B16F10 cells as compared with 6-O-desulfated heparin-induced tumor cells. "
4.	Myocardial Infarction 12/01/2022 - "Administration of 6-O-desulfated heparin significantly reduced creatine kinase activity, myocardial infarct size and cell apoptosis in mice subjected to 30 min of myocardial ischemia following 2 h of reperfusion, accompanied by a reverse in miR-199a-5p elevation, klotho downregulation and reactive oxygen species (ROS) accumulation. "
5.	Hypoxia (Hypoxemia) 12/01/2022 - "Consistent with the results in vivo, 6-O-desulfated heparin significantly ameliorated hypoxia/reoxygenation-induced injury, upregulated klotho and decreased miR-199a-5p levels and ROS accumulation, and these effects were reversed by miR-199a-5p mimics. "

Related Drugs and Biologics

1.	Heparin Lyase (heparin lyase)
2.	Reactive Oxygen Species (Oxygen Radicals)
3.	Interleukin-6 (Interleukin 6)
4.	Proteins (Proteins, Gene)
5.	Heparin (Liquaemin)
6.	Creatine Kinase (Creatine Phosphokinase)