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N- (6- (2- aminophenylamino)- 6- oxohexyl)- 4- methylbenzamide

structure in first source

Also Known As:

RGFP109

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Boehm-Sturm, Philipp: 1 article (01/2021)
2.	Harms, Christoph: 1 article (01/2021)
3.	Hecklau, Katharina: 1 article (01/2021)
4.	Kilic, Busra: 1 article (01/2021)
5.	Koch, Stefan Paul: 1 article (01/2021)
6.	Mehkary, Mustafa Hussain: 1 article (01/2021)
7.	Mueller, Susanne: 1 article (01/2021)
8.	Yildirim, Ferah: 1 article (01/2021)
9.	Chen, Bao-Dong: 1 article (12/2016)
10.	Chen, Lei: 1 article (12/2016)

Related Diseases

1.	Dyskinesias (Dyskinesia) 02/01/2013 - "RGFP109 had no acute effects on dyskinesia after single or 6 days once-daily treatment (both P > 0.05). " 02/01/2013 - "However, one week following cessation of RGFP109, dyskinesia and duration of ON-time with disabling dyskinesia were reduced by 37% and 50%, respectively (both P < 0.05), compared to that seen previously with L-DOPA alone. " 02/01/2013 - "RGFP109, a histone deacetylase inhibitor attenuates L-DOPA-induced dyskinesia in the MPTP-lesioned marmoset: a proof-of-concept study."
2.	Glioma (Gliomas) 06/01/2023 - "The results showed that an HDAC1 inhibitor (RGFP109) could inhibit the EMT process in glioma cells in vitro, thereby affecting the invasion and migration of cells. "
3.	Glioblastoma (Glioblastoma Multiforme) 12/01/2016 - "Histone Deacetylase Inhibitor RGFP109 Overcomes Temozolomide Resistance by Blocking NF-κB-Dependent Transcription in Glioblastoma Cell Lines."
4.	Atrophy 01/01/2021 - "We also found, by volumetric MRI, a widespread brain atrophy in the R6/1 mice at the symptomatic disease stage, on which RGFP109 showed no significant effects. "

Related Drugs and Biologics

1.	Histone Deacetylase Inhibitors
2.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
3.	Levodopa (L Dopa)
4.	Temozolomide (Temodar)