viscosine

a GABA-A receptor agonist with anxiolytic and anticonvulsant activities; isolated from Dodonaea viscosa; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Fever (Fevers) 09/03/2019 - "Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies." 09/03/2019 - "These findings suggest that viscosine shows antipyretic properties by reducing the concentration of prostaglandin E2 in brain through its mPGES-1 inhibitory action and make it a potential lead compound for developing effective and safer antipyretic drugs for treating fever and related pathological conditions." 09/03/2019 - "The antipyretic potential of viscosine, a natural product isolated from the medicinal plant Dodonaea viscosa, was investigated using yeast-induced pyrexia rat model, and its structure-activity relationship was investigated through molecular docking analyses with the target enzymes cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1). "
2.	Inflammation (Inflammations) 11/01/2016 - "Viscosine attenuated the inflammation in the liver around the injured central vein region by downregulating the CCl4 induced activation of hepatic CD68+ macrophages, thereby reducing their number as well. "

1.	Antipyretics
2.	Cyclooxygenase 2 (Cyclooxygenase-2)
3.	Cyclooxygenase 1
4.	Dinoprostone (PGE2)
5.	Enzymes
6.	Prostaglandin-E Synthases