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3- methylphenyl- 2,3,4,5- tetrahydro- 1H- benzo(d)azepin- 7- ol

a sigma-1 receptor modulator with anticonvulsant activity; structure in first source

Also Known As:

SOMCL-668

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - 3-methylphenyl-2,3,4,5-tetrahydro-1H-benzo(d)azepin-7-ol: 2

Experts

1.	Chen, Jiali: 1 article (01/2022)
2.	Chen, Jiaojiao: 1 article (01/2022)
3.	Li, Guangying: 1 article (01/2022)
4.	Qin, Pingping: 1 article (01/2022)
5.	Waddington, John L: 1 article (01/2022)
6.	Ye, Na: 1 article (01/2022)
7.	Zhen, Xuechu: 1 article (01/2022)
8.	Guo, Lin: 1 article (05/2016)
9.	Jiang, Hua-Feng: 1 article (05/2016)
10.	Wang, Yun: 1 article (05/2016)

Related Diseases

1.	Cognitive Dysfunction 01/01/2022 - "SOMCL-668 not only attenuated acute PCP-induced hyperactivity and PPI disruption, but also ameliorated social deficits and cognitive impairment induced by chronic PCP treatment. " 01/01/2022 - "Furthermore, in vivo lower dose of SOMCL-668 exerted positive modulation of improvement in social deficits and cognitive impairment induced by the selective sigma-1 agonist PRE084. " 01/01/2022 - "This was confirmed using sigma-1 receptor knockout mice, in which SOMCL-668 failed to ameliorate PPI disruption and hyperactivity induced by acute PCP and social deficits and cognitive impairment induced by chronic PCP treatment. "
2.	Anhedonia 05/01/2016 - "In the chronic unpredicted mild stress (CUMS) model, chronic application of SOMCL-668 rapidly ameliorated anhedonia-like behavior (within a week), accompanying with the enhanced expression of brain-derived neurotrophic factor (BDNF) and phosphorylation of glycogen synthase kinase 3β (GSK3β) (Ser-9) in the hippocampus. "
3.	Schizophrenia (Dementia Praecox) 01/01/2022 - "Moreover, administration of the PI3K/AKT inhibitor LY294002 abolished amelioration by SOMCL-668 of chronic PCP-induced schizophrenia-related behaviors by inhibition of BDNF expression. " 01/01/2022 - "The present work investigates the potential therapeutic effects of SOMCL-668 on phencyclidine (PCP)-induced schizophrenia-related behavior in mice and further elucidates underlying mechanisms for its antipsychotic-like effects. "

Related Drugs and Biologics

1.	2- (4- morpholino)ethyl- 1- phenylcyclohexane- 1- carboxylate
2.	Brain-Derived Neurotrophic Factor (BDNF)
3.	Therapeutic Uses
4.	Glycogen Synthase Kinases
5.	Antipsychotic Agents (Antipsychotics)
6.	Phencyclidine (Angel Dust)
7.	Sigma-1 Receptor
8.	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- one