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2- (4- morpholino)ethyl- 1- phenylcyclohexane- 1- carboxylate

structure given in first source

Also Known As:

PRE 084; PRE-084; PRE084

Networked: 43 relevant articles (8 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Morpholines: 6
      - 2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate: 43

Experts

1.	Lee, Jang-Hern: 7 articles (01/2022 - 11/2008)
2.	Choi, Sheu-Ran: 6 articles (01/2022 - 08/2011)
3.	Beitz, Alvin J: 5 articles (12/2021 - 11/2008)
4.	Han, Ho-Jae: 5 articles (01/2019 - 11/2008)
5.	Roh, Dae-Hyun: 4 articles (01/2019 - 11/2008)
6.	Yoon, Seo-Yeon: 4 articles (01/2019 - 11/2008)
7.	Choi, Hoon-Seong: 3 articles (01/2019 - 08/2013)
8.	Kang, Suk-Yun: 3 articles (01/2019 - 08/2011)
9.	Kwon, Soon-Gu: 3 articles (12/2016 - 08/2011)
10.	Kim, Hyun-Woo: 2 articles (01/2022 - 11/2008)

Related Diseases

1.	Myocardial Ischemia (Ischemic Heart Diseases) 03/05/2018 - "Although the sigma-1 receptor agonist PRE-084 exhibits a cardioprotective effect in some studies, the benefits in cases of myocardial ischemia/reperfusion (I/R) are not clear. " 03/05/2018 - "Sigma-1 Receptor Stimulation with PRE-084 Ameliorates Myocardial Ischemia-Reperfusion Injury in Rats."
2.	Embolic Stroke 05/30/2011 - "Treatment with PRE-084 afforded neuroprotection following embolic stroke as evidenced by significantly reduced infarct volume and improved behavioural outcome. " 05/30/2011 - "In the present study, rats were subjected to embolic stroke or sham stroke and were treated with the sigma-1 receptor agonist PRE-084 (5mg/kg i.p.) or saline vehicle 3 and 24h after stroke. " 05/30/2011 - "Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats."
3.	Infarction (Infarctions) 05/30/2011 - "Treatment with PRE-084 afforded neuroprotection following embolic stroke as evidenced by significantly reduced infarct volume and improved behavioural outcome. " 06/01/2018 - "Interestingly, neither mice with the genetic deletion of σ1R nor wild-type mice that were pre-treated with the σ1R agonist PRE084 showed beneficial effects after S1RA administration with regard to stroke infarction. " 01/01/2008 - "Treatment with dimemorfan (1.0 microg/kg and 10 microg/kg, i.v.) either 15 min before ischemia or at the time of reperfusion, like the putative sigma(1) receptor agonist, PRE084 (10 microg/kg, i.v.), ameliorated the size of the infarct zone by 67-72% or 51-52%, respectively, which was reversed by pre-treatment with the selective sigma(1) receptor antagonist, BD1047 (20 microg/kg, i.v.). " 05/30/2011 - "Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats."
4.	Amnesia (Dissociative Amnesia) 12/01/1994 - "Moreover, the PCP derivative PRE-084, acting selectively at sigma sites, reverses the amnesia induced by a drug acting at the PCP site." 05/01/2002 - "The behavioural efficacy of the selective sigma( 1) agonists igmesine and PRE-084 -- reversion of the scopolamine-induced amnesia in the passive avoidance test; diminution of the immobility duration in the forced swimming test -- were significantly higher in C57BL/6 than in Swiss. " 12/01/1994 - "Furthermore, PRE-084 did not affect scopolamine (1 mg/kg SC) induced amnesia but significantly attenuated mecamylamine (10 mg/kg IP) induced amnesia. " 07/01/1999 - "In particular, the anti-amnesic effects induced by the novel sigma1-receptor agonists, such as (+)-pentazocine, SA4503 and PRE-084, were shown in beta amyloid-peptide-induced, basal forebrain (BF)-lesioned and carbon monoxide (CO)-induced amnesia models and senescence-accelerated mouse (SAM). "
5.	Cognitive Dysfunction 01/01/2022 - "Furthermore, in vivo lower dose of SOMCL-668 exerted positive modulation of improvement in social deficits and cognitive impairment induced by the selective sigma-1 agonist PRE084. " 09/01/2022 - "Compounds such as PRE-084 or pridopidine (ACR16) are being studied as a potential treatment against cognitive decline associated with neurodegenerative disease, also to include Alzheimer's disease. "

Related Drugs and Biologics

1.	Sigma-1 Receptor
2.	Scopolamine (Hyoscine)
3.	Adenine
4.	Sulfonic Acids
5.	Antioxidants
6.	igmesine
7.	sym-trinitrobenzene
8.	3- methylphenyl- 2,3,4,5- tetrahydro- 1H- benzo(d)azepin- 7- ol
9.	Ligands
10.	pridopidine

Related Therapies and Procedures

1.	Intraventricular Infusions
2.	Intraperitoneal Injections