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bisnaphthalimidopropyl diaminodicyclohexylmethane

has antineoplastic activity; structure in first source

Also Known As:

BNIPDaCHM

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Barron, Gemma A: 3 articles (10/2016 - 03/2013)
2.	Bermano, Giovanna: 3 articles (10/2016 - 03/2013)
3.	Goua, Marie: 2 articles (10/2016 - 12/2015)
4.	Kong Thoo Lin, Paul: 2 articles (10/2016 - 12/2015)
5.	Kopsida, Maria: 1 article (10/2016)
6.	Iwai, Shigenori: 1 article (12/2015)
7.	Kuraoka, Isao: 1 article (12/2015)
8.	Grabowska, Joanna A: 1 article (03/2013)
9.	Kaur, Simranjeet: 1 article (03/2013)
10.	Lima, Raquel T: 1 article (03/2013)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 10/18/2016 - "Based on these findings, further investigation is under way to assess the potential efficacy of trans,trans-BNIPDaCHM and BNIPPiEth in treating human breast cancer." 10/18/2016 - "Two of the novel BNIP derivatives, BNIPPiEth and trans,trans-BNIPDaCHM, exhibited greater cytotoxicity against the two breast cancer cell lines studied, compared to BNIPDaCHM. "
2.	Neoplasms (Cancer) 10/18/2016 - "By modifying the linker sequence of bisnaphthalimidopropyl diaminodicyclohexylmethane (BNIPDaCHM), a previously synthesised BNIP derivative with anti-cancer properties, three novel BNIP derivatives were designed. " 12/05/2015 - "Bisnaphthalimidopropyl diaminodicyclohexylmethane (BNIPDaCHM) bisintercalates to DNA and is a potential anti-cancer therapeutic. "
3.	Triple Negative Breast Neoplasms 12/05/2015 - "In an attempt to elucidate the mechanism(s) underlying the potential of BNIPDaCHM; earlier work was extended to investigate its effect on DNA damage and repair as well as cell cycle modulation, in a triple negative breast cancer (TNBC) cell line in vitro. " 12/05/2015 - "Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression."
4.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/01/2013 - "In the present work, we report for the first time the effect of the previously synthesised compounds, BNIPDaCHM and NPA, together with a new BNIP derivative (BNIP-3,4-DaDPM) in the in vitro growth of a non-small cell lung cancer cell line (NCI-H460). "

Related Drugs and Biologics

1.	bisnaphthalimidopropyl diaminodicyclohexylmethane
2.	DNA (Deoxyribonucleic Acid)