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N-(2-fluoropropionyl)glutamic acid

a PET imaging agent; structure in first source

Also Known As:

(18F)FPGLU; N-(2-(18F)fluoropropionyl)-L-glutamate; N-(2-fluoropropionyl)glutamate

Networked: 3 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Acidic Amino Acids: 44
    - Glutamates: 45
      - N-(2-fluoropropionyl)glutamic acid: 3
  - Dicarboxylic Amino Acids: 20
    - Glutamates: 45
      - N-(2-fluoropropionyl)glutamic acid: 3

Experts

1.	Tang, Ganghua: 3 articles (01/2021 - 01/2014)
2.	Lin, Liping: 1 article (01/2021)
3.	Liu, Shaoyu: 1 article (01/2021)
4.	Ma, Hui: 1 article (01/2021)
5.	Nie, Dahong: 1 article (01/2021)
6.	Su, Shu: 1 article (01/2021)
7.	Xiang, Xianhong: 1 article (01/2021)
8.	Xiong, Ying: 1 article (01/2021)
9.	Yuan, Gongjun: 1 article (01/2021)
10.	Gao, Siyuan: 1 article (05/2020)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 01/01/2021 - "Purpose: N-(2-[18F]fluoropropionyl)-L-glutamate ([18F]FPGLU) for hepatocellular carcinoma (HCC) imaging has been performed in our previous studies, but its radiosynthesis method and stability in vivo need to be improved. "
2.	Glioma (Gliomas) 05/01/2020 - "The transport mechanism of [18F]FPGLU in glioma C6 and lung adenocarcinoma SPC-A-1 cell lines mainly involves in glutamate transporter EAAC1. " 05/01/2020 - "In this study, the relationship between glutamate transporter excitatory amino acid carrier 1 (EAAC1) expression and [18F]FPGLU uptake in rat C6 glioma cell lines and human SPC-A-1 lung adenocarcinoma cell lines was investigated. "
3.	Adenocarcinoma of Lung 05/01/2020 - "The transport mechanism of [18F]FPGLU in glioma C6 and lung adenocarcinoma SPC-A-1 cell lines mainly involves in glutamate transporter EAAC1. " 05/01/2020 - "In this study, the relationship between glutamate transporter excitatory amino acid carrier 1 (EAAC1) expression and [18F]FPGLU uptake in rat C6 glioma cell lines and human SPC-A-1 lung adenocarcinoma cell lines was investigated. "
4.	Neoplasms (Cancer) 05/01/2020 - "Moreover, the uptake of [18F]FPGLU in EAAC1 knock-down SPC-A-1(shRNA) xenografts was significantly lower than that in SPC-A-1 xenografts, with tumor/muscle ratios of 3.01 vs. 1.67 at 60 min post-injection of [18F]FPGLU. " 01/01/2014 - "We were able to use [18F]FPGLU in PET imaging and obtained high tumor to background ratios when visualizing tumors tissues in animal models." 01/01/2014 - "[18F]FPGLU was stable in urine, tumor tissues, and blood. " 05/01/2020 - "We have reported that N-(2-[18F]fluoropropionyl)-L-glutamate ([18F]FPGLU) was a potential amino acid tracer for tumor imaging with positron emission tomography (PET). "

Related Drugs and Biologics

1.	Glutamic Acid (Glutamate)
2.	Amino Acid Transport System X-AG (Glutamate Transporter)
3.	Excitatory Amino Acids
4.	Amino Acids