N- acetylcysteine- 1- (4- chlorobenzoyl)- 5- methoxy- 2- methyl- 1H- indole- 3- acetic acid 4-(nitrooxy)butyl ester

a nitric oxide donor with antitrypanosomal activity; structure in first source

Also Known As:

NCX-2121; NO-indomethacin

Networked: 8 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indomethacin: 9574
        N-acetylcysteine-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 4-(nitrooxy)butyl ester: 8
Inorganic Chemicals: 9
- Electrolytes: 16106
  - Ions: 7857
    - Anions: 3501
      - Nitrates: 6625
        N-acetylcysteine-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 4-(nitrooxy)butyl ester: 8
- Nitrogen Compounds: 67
  - Nitric Acid: 155
    - Nitrates: 6625
      - N-acetylcysteine-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 4-(nitrooxy)butyl ester: 8
Organic Chemicals: 133
- Nitrates: 6625
  - N-acetylcysteine-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 4-(nitrooxy)butyl ester: 8

Experts

1.	Cecchini, Rubens: 1 article (02/2015)
2.	Malvezi, Aparecida Donizette: 1 article (02/2015)
3.	Martins, Maria Isabel Lovo: 1 article (02/2015)
4.	Martins-Pinge, Marli Cardoso: 1 article (02/2015)
5.	Panis, Carolina: 1 article (02/2015)
6.	Pinge-Filho, Phileno: 1 article (02/2015)
7.	Rizzo, Luiz Vicente: 1 article (02/2015)
8.	Tatakihara, Vera Lucia Hideko: 1 article (02/2015)
9.	Yamada-Ogatta, Sueli Fumie: 1 article (02/2015)
10.	Yamauchi, Lucy Megumi: 1 article (02/2015)

Related Diseases

1.	Parasitemia 02/05/2015 - "Within the NO-indomethacin-treatment group, parasitemia and mortality (100%) were higher and oxidative stress in erythrocytes, anemia, and entry of parasites into macrophages were significantly greater than that seen in controls. "
2.	Anemia 02/05/2015 - "Within the NO-indomethacin-treatment group, parasitemia and mortality (100%) were higher and oxidative stress in erythrocytes, anemia, and entry of parasites into macrophages were significantly greater than that seen in controls. "
3.	Infections 02/05/2015 - "In this study, we investigated the effect of NO-indomethacin on parasite burden, cell invasion, and oxidative stress in erythrocytes during the acute phase of infection. "
4.	Neoplasms (Cancer) 06/01/2006 - "Our results suggest that NO-indomethacin at 40 and 80 ppm and NO-aspirin at 3,000 ppm significantly suppressed both tumor incidence (P < 0.01) and multiplicity (P < 0.001). " 01/01/1993 - "Mice receiving carcinogen and no indomethacin supplementation had a 24% incidence of urinary bladder tumors; mice receiving 7.5 mg/kg and 15 mg of indomethacin had a 5% and 0% incidence of urinary bladder tumors, respectively. " 06/01/2006 - "NO-indomethacin at 40 and 80 ppm and NO-aspirin at 3,000 ppm significantly inhibited the colon tumors' (P < 0.01 to P < 0.001) total cyclooxygenase (COX), including COX-2 activity (52-75% inhibition) and formation of prostaglandin E2 (PGE2), PGF2alpha, and 6-keto-PGF1alpha, and TxB2 from arachidonic acid (53-77% inhibition). "
5.	Hemorrhage 05/01/1981 - "Although no indomethacin side effects occurred in phase 1, in phase 2 indomethacin administration was associated with minimal, but statistically significant, transient impaired renal function and, in three infants (23%), mild upper gastrointestinal bleeding. " 06/01/1983 - "Although mortality did not differ significantly, infants given indomethacin only if usual therapy failed (strategy 2) had a lower incidence of bleeding than those to whom indomethacin was given with initial medical therapy (strategy 1) and lower rates of pneumothorax and retrolental fibroplasia than those to whom no indomethacin was administered, with surgery the only backup to medical therapy (strategy 3). "

Related Drugs and Biologics

1.	Indomethacin (Indometacin)
2.	Arachidonic Acid (Vitamin F)
3.	Dinoprost
4.	Dinoprostone (PGE2)
5.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
6.	Carcinogens
7.	Azoxymethane
8.	N- acetyl- S- (alpha- methyl- 4- (2- methylpropyl)benzeneacetyl)cysteine 4-(nitrooxy)butyl ester
9.	1- (4- chlorobenzoyl)- 5- methoxy- 2- 1H- indole- 3- acetic acid 3-(nitrooxymethyl)phenyl ester
10.	nitroaspirin

Related Therapies and Procedures

1.	Tocolysis
2.	Therapeutics