Abstract | OBJECTIVES: METHODS: We evaluated data from 147 children ages 6 to 24 mo evaluated in the MAL-ED (Interactions of Malnutrition and Enteric Disease) case-control study following recruitment from a nutrition clinic for impoverished families in Fortaleza, Brazil. We used nonparametric tests and linear regression to evaluate relationships between current symptoms of infections (assessed by questionnaire), systemic inflammation (assessed by high-sensitivity C-reactive protein [ hsCRP]), the GH insulin-like growth factor-1 (IGF-1) axis, and measures of anthropometry. All models were adjusted for age and sex. RESULTS: Children with recent symptoms of diarrhea, cough, and fever (compared with those without symptoms) had higher hsCRP levels; those with recent diarrhea and fever also had lower IGF-1 and higher GH levels. Stool myeloperoxidase was positively associated with serum hsCRP. hsCRP was in turn positively associated with GH and negatively associated with IGF-1 and IGF-binding protein-3 (IGFBP-3), suggesting a state of GH resistance. After adjustment for hsCRP, IGF-1 and IGFBP-3 were positively and GH was negatively associated with Z scores for height and weight. CONCLUSIONS:
Infection and inflammation were linked to evidence of GH resistance, whereas levels of GH, IGF-1, and IGFBP-3 were associated with growth indices independent of hsCRP. These data implicate complex interrelationships between infection, nutritional status, GH axis, and linear growth in children from a developing area.
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Authors | Mark D DeBoer, Rebecca J Scharf, Alvaro M Leite, Alessandra Férrer, Alexandre Havt, Relana Pinkerton, Aldo A Lima, Richard L Guerrant |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
Vol. 33
Pg. 248-253
(Jan 2017)
ISSN: 1873-1244 [Electronic] United States |
PMID | 27712965
(Publication Type: Journal Article)
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Copyright | Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- IGF2 protein, human
- IGFBP3 protein, human
- Insulin-Like Growth Factor Binding Protein 3
- Insulin-Like Growth Factor II
- C-Reactive Protein
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Topics |
- Biomarkers
(blood)
- Body Height
- Brazil
(epidemiology)
- C-Reactive Protein
(analysis)
- Case-Control Studies
- Cohort Studies
- Cross-Sectional Studies
- Female
- Growth Disorders
(epidemiology, etiology)
- Humans
- Infant
- Infant Nutritional Physiological Phenomena
- Infections
(complications, immunology)
- Insulin-Like Growth Factor Binding Protein 3
(blood)
- Insulin-Like Growth Factor II
(analysis)
- Male
- Malnutrition
(blood, complications, immunology, physiopathology)
- Nutritional Status
- Poverty
- Prevalence
- Thinness
(epidemiology, etiology)
- Wasting Syndrome
(epidemiology, etiology)
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