Diarrhea

Subscribe to Selected New Research on Diarrhea

11537 relevant articles (765 outcomes, 1070 trials/studies) found for this Disease

Description: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

Also Known As:

Diarrheas

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions

Signs and Symptoms

Digestive Signs and Symptoms

Diarrhea: 11537

Infantile Diarrhea: 146

Related Diseases

1.	Infection
2.	Dehydration (Water Stress)
3.	Cholera
4.	Vomiting
5.	Abdominal Pain (Pain, Abdominal)
892 Diseases and 5743 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	DuPont, Herbert L: 20 articles (08/2008 - 10/2002)
2.	Jiang, Zhi-Dong: 12 articles (09/2007 - 08/2003)
3.	Okhuysen, Pablo C: 10 articles (08/2008 - 07/2003)
4.	Ericsson, Charles D: 10 articles (09/2007 - 05/2003)
5.	Black, Robert E: 8 articles (05/2008 - 12/2003)
6.	Oldfield, Edward C: 8 articles (01/2008 - 01/2003)
7.	Bhandari, Nita: 6 articles (05/2008 - 05/2002)
8.	Guerrant, Richard L: 5 articles (01/2007 - 06/2002)
9.	Ericsson, C D: 5 articles (12/2001 - 05/2000)
10.	Ridpath, Julia F: 4 articles (08/2008 - 06/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Diarrhea:

1.	Octreotide (Sandostatin)FDA LinkGeneric 06/01/1995 - "Octreotide is very effective in controlling RRT diarrhea" 09/01/2007 - "Administration of octreotide was effective in relieving his secretory diarrhea" 12/01/2006 - "Long-acting octreotide is effective in the treatment of severe diarrhea in patients after pelvic pouch surgery." 06/01/1998 - "The demonstrated safety and efficacy of octreotide in this patient population support further investigation of this therapeutic strategy for GVHD-induced diarrhea" 06/01/1998 - "CONCLUSIONS: In this pilot study, octreotide treatment was effective in reducing the amount of diarrhea in patients with acute GVHD" Get all the results and reference details, order at left...
2.	Loperamide (Imodium)FDA LinkGeneric 02/01/1996 - "Loperamide was considered the most effective agent for controlling delayed diarrhea" 03/01/1984 - "Most symptoms improved significantly on placebo compared with the baseline period, but three of these [diarrhea (P less than 0.01), urgency (P less than 0.01) and borborygmi (P less than 0.05)] showed a further significant improvement on loperamide" 06/01/2005 - "Imodium is more effective than placebo at improving stool consistency and decreasing stool frequency in patients with IBS, and it may be an important component for treating diarrhea-predominant IBS" 03/01/1996 - "Grade 3 or 4 diarrhea was substantially more prevalent in the initial 18 patients on study, with an incidence rate of 56%; a significant reduction in the incidence of severe diarrhea to 9% was noted with strict adherence to an antidiarrheal regimen of loperamide and diphenyldramine" 01/01/2000 - "These data seem to suggest that high-dose loperamide is effective in patients with moderate diarrhea and can be regarded as the treatment of choice" Get all the results and reference details, order at left...
3.	ORALIT (ORS)IBA 03/01/1994 - "The exact composition of ORS will probably continue to evolve over the next few years, because: 1) It is important to have a single ORS, so that all patients with dehydrating diarrheas of any cause and in any age group can be successfully treated with the same solution" 12/01/1993 - "Due to high literacy rate and health consciousness, the educated and majority of literate parents of Patna town were better aware, more factual and had rational view regarding causes, method of prevention, fundamentals of use of ORS and home management of diarrhea in children, although certain aspects are yet to be cleared to them.(ABSTRACT TRUNCATED AT 250 WORDS)" 11/01/1991 - "Among children with rotavirus diarrhea, no significant differences were observed between the 23 children who received improved ORS and the 20 who received standard ORS." 11/01/1991 - "Improved ORS did not produce significant reduction in the volume of diarrhea stools" 01/01/1999 - "Moreover, the management of diarrhea could be improved through the more liberal distribution of ORS sachets." Get all the results and reference details, order at left...
4.	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 12/01/1990 - "Synthetic somatostatin analogues have proved to be clinically effective in controlling this diarrhea" 03/01/1988 - "This case report shows that somatostatin is also therapeutically effective in non-secretory diarrhea." 04/01/1983 - "These findings should be taken into consideration when developing a gut-specific somatostatin analog that can be useful in the treatment of diarrhea." 07/01/1992 - "A trial of somatostatin therapy was ineffective in controlling the diarrhea" 11/01/2003 - "Somatostatin analogues are effective as second-line therapy or as first-line therapy for patients with grade 3/4 diarrhea" Get all the results and reference details, order at left...
5.	ZincIBA 06/01/2007 - "METHODS AND RESULTS: Several reports from developing countries have demonstrated that supplements of zinc also provide significant reduction in stool output and duration, persistency, and severity of diarrhea" 10/01/2006 - "CONCLUSION: Supplemental zinc had no significant effect on the duration or remission of diarrhea in HIV-infected adults." 08/01/1999 - "CONCLUSION: There was a significant reduction in the duration of persistent diarrhea in selected subgroups of zinc-supplemented ambulatory patients in this population." 06/01/1997 - "These pathophysiological conclusions are supported by several controlled clinical traits which have provided evidence that zinc supplementation results in significant reduction in the risk of continued diarrhea" 02/01/1990 - "Repeat estimation at discharge in 38 patients (25 in Group I, 13 in Group II) revealed a significant reduction in both tissue and serum zinc and only tissue zinc in acute and chronic diarrhea, respectively" Get all the results and reference details, order at left...
6.	Glucose (Dextrose)FDA LinkGeneric 08/01/1988 - "The present study was undertaken in order to assess whether an oral glucose/electrolyte solution designed for fluid replacement (Na+ concentration 75 mmol/l) and an oral glucose/electrolyte solution designed for maintenance of hydration (Na+ concentration 45 mmol/l) would be safe and effective in the treatment of acute childhood diarrhea in a developed country" 01/01/1991 - "The systematic studies of pH and glucose of stools did not appear to be useful for children with acute diarrhea who had a satisfactory evolution." 12/01/1985 - "Because previous studies have strongly suggested that in acute TGE diarrhea the epithelium is composed of relatively undifferentiated crypt-type cells, we speculate that high-affinity D-glucose carriers are lacking in normal crypt epithelial cells and that they are incorporated into brush-border membranes of jejunal enterocytes as the cells differentiate in the course of their migration from crypt to villus." 01/01/1977 - "All children with diarrhea aged up to 5 years and residing in 2 communities (community B was the study, community M the control) in a province in the Philippines were studied to test the hypothesis that an oral glucose-electrolyte solution (Oresol) used freely for outpatient children with diarrhea would improve their nutritional status" 02/01/1975 - "It was discovered, in a study among Apache children, that early and rapid replacemtnt of volume loss and correction of electrolyte imbalance using glucose-electrolyte solutions administered orally can restore physical well-being and appetite to children suffering from acute diarrhea, and hence enhance these children's nutritional status" Get all the results and reference details, order at left...
7.	irinotecan (Camptosar)FDA LinkGeneric 08/01/2005 - "In particular, the AUC of SN-38 was markedly decreased to 56 from 107 ng.h/mL. Intestinal alkalinization was effective in preventing CPT-11-induced diarrhea, but this treatment changed the pharmacokinetics of CPT-11 and SN-38 in the body." 01/01/2005 - "Further studies are needed to identify the molecular targets associated with CPT-11 toxicity and safe and effective agents for alleviating CPT-11-induced diarrhea." 06/01/2008 - "The delayed diarrhea symptoms induced by irinotecan also seemed to be improved" 03/01/2008 - "The DLT is diarrhea at a MTD of 100 mg/m2 of CPT-11, and 80 mg/m2 CPT-11 is recommended for the next phase II trial." 01/01/2007 - "As the association was seen in patients not genetically predisposed at risk for diarrhea due to UGT1A128, confirmatory studies of the relationships of ABCC2 genotypes and irinotecan disposition and toxicity are warranted." Get all the results and reference details, order at left...*
8.	AntibodiesIBA 01/01/2001 - "BACKGROUND: Hyperimmunized bovine colostrum containing antibodies has been shown to be effective in the treatment of rotavirus diarrhea" 04/01/1999 - "coli K88+ MB-induced diarrhea in 3-day-old piglets was cured 24 h after treating with egg-yolk antibodies while those treated with egg-yolk powder from conventional hens continued to have diarrhea and 62.5% of them died of severe diarrhea" 07/01/1992 - "The protective effects of the egg yolk antibodies were tested in the rabbit reversible ileal tie model of diarrhea" 06/01/2003 - "Efficacy of an infant formula containing anti-Escherichia coli colostral antibodies from hyperimmunized cows in preventing diarrhea in infants and children: a field trial." 06/01/1991 - "In a first field study using egg yolk antibodies, 92% of 299 diarrhea affected piglets were cured" Get all the results and reference details, order at left...
9.	Anti-Bacterial Agents (Antibiotics)IBA 03/01/2001 - "Noteworthy results published include the following: 1) raw juice of garlic was found to be effective against many common pathogenic bacteria-intestinal bacteria, which are responsible for diarrhea in humans and animals; 2) garlic is effective even against those strains that have become resistant to antibiotics; 3) the combination of garlic with antibiotics leads to partial or total synergism; 4) complete lack of resistance has been observed repeatedly; 5) even toxin production by microorganisms is prevented by garlic" 01/01/1993 - "difficile diarrhea in high-risk patients on antibiotics may also have merit if an effective and safe biologic agent can be identified" 06/01/2001 - "Are antibiotics effective for travelers' diarrhea?" 12/01/2000 - "Antibiotics are effective in the treatment of bacterial overgrowth-related diarrhea." 08/15/2006 - "Our objective in this study was to assess the efficacy of probiotics (of any specified strain or dose) for the prevention of antibiotic-associated diarrhea in children and to assess adverse events associated with the use of probiotics when coadministered with antibiotics to children" Get all the results and reference details, order at left...
10.	Immunoglobulins (Immunoglobulin)IBA 01/01/1993 - "Treatment of refractory diarrhea with 10 g immunoglobulins from bovine colostrum per day constitutes an important therapeutic approach and led to complete (40%) or partial (24%) remission of diarrhea in 64% of the patients described here." 05/01/2006 - "CONCLUSIONS: Intravenous immunoglobulin may be effective for severe, refractory, or recurrent Clostridium difficile diarrhea after failed conventional treatment." 12/01/1998 - "CONCLUSIONS: Treatment with antirotavirus immunoglobulin of bovine colostral origin is effective in the management of children with acute rotavirus diarrhea." 02/01/1991 - "Efficacy of colostral immunoglobulins for therapeutic and preventive treatments of calf diarrhea." 10/01/1993 - "Passive protection against bovine rotavirus-induced diarrhea in murine model by specific immunoglobulins from chicken egg yolk." Get all the results and reference details, order at left...
2449 Drugs and Important Bio-Agents and 10083 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Fluid Therapy (Oral Rehydration Therapy) 05/01/1996 - "Oral rehydration therapy (ORT) has dramatically reduced the morbidity and mortality associated with acute infectious diarrhea" 01/01/1991 - "Most health professionals in developing and developed countries consider oral rehydration therapy (ORT) to be the most effective treatment for diarrhea" 01/01/1998 - "Cost-effectiveness analysis indicates that some water supply and sanitation (WSS) interventions are very cost-effective in controlling diarrhea among children under age 5 years, as cost-effective as oral rehydration therapy" 12/01/1977 - "In all, 16 children suffering from sporadic, unspecific diarrhea over a period of 9 months showed marked improvement of the condition within 1-2 days of cup and spoon rehydration." 08/01/1991 - "We sought to determine the efficacy of three different types of treatment in children with acute diarrhea who, during the oral rehydration period, had high stool output (greater than 10 mL/kg per hour)" Get all the results and reference details, order at left...
2.	Drug Therapy (Chemotherapy) 02/01/1992 - "This was justified by slow tumour growth and also facilitated control of diarrhea and ensured a greater efficacy of possible postoperative chemotherapy" 03/01/1991 - "After institution of chemotherapy, watery diarrhea persisted despite remission of the underlying disease" 09/01/2007 - "AIM: The primary aim of this study was to investigate the probiotic mixture, VSL#3, for amelioration of chemotherapy-induced diarrhea (CID)" 02/01/2007 - "To decrease the incidence of late onset, severe diarrhea observed in a previous study, a phase I study was conducted to determine the maximum tolerated dose (MTD) of S-1 utilizing a 14-day schedule, repeated every 21 days, in patients with chemotherapy-refractory upper gastrointestinal malignancies" 12/01/2003 - "SangStat also initiated a phase I trial in chemotherapy-induced diarrhea in the first quarter of 2003 and anticipates initiating phase I trials in the gastrointestinal complications of HIV by the end of 2003." Get all the results and reference details, order at left...
3.	Aftercare (After-Treatment) 06/01/1996 - "A significant reduction in the duration of diarrhea and other symptoms was observed after treatment, regardless of whether a pathogen was detected (P = .0001)" 01/01/2007 - "His general body symptoms, including the bloody diarrhea, improved after treatment" 05/01/1988 - "Routine test-of-cure stool cultures can be useful for evaluating treatment failures and for assessing asymptomatic carriage of enteropathogens after treatment, but they are not mandated in the design of placebo-controlled antimicrobial treatment trials in traveler's diarrhea when the focus of the trial is clinical efficacy." 11/01/2007 - "There was a significant decrease in diarrhea score before and after treatment in the 3 groups (A: 4.78 +/- 0.76, 0.65 +/- 0.53; B: 4.13 +/- 0.65, 1.25 +/- 0.62; C: 4.65 +/- 0.88, 1.45 +/- 0.70) (P < 0.05)" 03/01/2007 - "MATERIAL AND METHODS: Thirty-one patients (9 F, 22 M, median age 39 years, range 19-63 years) with persistent diarrhea after returning from tropical or subtropical areas agreed to undergo upper gastrointestinal endoscopy before and after treatment" Get all the results and reference details, order at left...
4.	Highly Active Antiretroviral Therapy (HAART) 06/01/2001 - "OBJECTIVE: Highly active antiretroviral therapy (HAART) has significantly decreased the incidence of infectious diarrhea affecting HIV-infected patients" 05/01/2007 - "The aims of this study were to compare the prevalence of diarrhea among HIV-infected and uninfected patients in the HAART era, and to evaluate the impact of diarrhea on health-related quality of life (HRQOL)" 02/01/2004 - "The study enrolled 100 consecutive HIV positive patients who had diarrhea while on HAART" 11/01/2007 - "PURPOSE: In the highly active antiretroviral therapy (HAART) era, HIV-related diarrhea remains common" 05/01/2007 - "INTRODUCTION: In the highly active antiretroviral therapy (HAART) era, HIV-related diarrhea remains common" Get all the results and reference details, order at left...
5.	Day Care (Partial Hospitalization) 01/01/1993 - "Rotavirus-positive diarrhea was also significantly greater in child day care (OR = 2.4, 95% CI 1.1-5.1)" 07/01/2008 - "This review focuses on the efficacy of probiotics for diarrhea in children in different settings: day-care centers, diarrhea acquired in the hospital, antibiotic-associated diarrhea, and treatment of acute infectious diarrhea" 10/01/1983 - "Contamination of hands, communal toys and other classroom objects appeared to play a role in the transmission of enteropathogens in day-care center diarrhea outbreaks and helped to explain the presence of multiple pathogens among those affected." 07/01/2008 - "For prevention of diarrhea acquired in day-care centers, 5 randomized and placebo-controlled trials have been published" 04/01/2006 - "PURPOSE: In the present study, we ascertained by molecular methods the species and the genotype of Cryptosporidium sp from a diarrhea outbreak diagnosed in a day care at the Hospital Clínicas, São Paulo University Medical School" Get all the results and reference details, order at left...
201 Therapies and Procedures and 2340 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Patient-Physician
Research Summary Report
on Diarrhea

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. CureHunter research summary reports will vary in length from 25 to 250 pages. Analytic charts allow you and your physicians to see at a glance your medication options—including new, promising, off-label and experimental.

Free Updates for 1 Year
All 765 Outcomes
Top 200 Key Medications
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Reference Details
Sample PDF for "Psoriasis" >>

Price:

$24.00 & Delivery via PDF download,
updates for 1 year

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License details >>

Price:

$490.00 access via web interface, 1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m", 1 year subscription

Proceed to Checkout >>