Type 1 Diabetes Mellitus (Autoimmune Diabetes)

9126  relevant articles (365 outcomes, 1346 trials/studies) found for this Disease

Autoimmune Diabetes; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type I; Autoimmune Diabete; Brittle Diabetes Mellitus; Diabete, Autoimmune; Diabetes Mellitus, Insulin Dependent; Diabetes Mellitus, Juvenile Onset; Diabetes Mellitus, Ketosis Prone; Diabetes Mellitus, Sudden Onset; Insulin-Dependent Diabetes Mellitus; Juvenile-Onset Diabetes Mellitus; Ketosis-Prone Diabetes Mellitus; Mellitus, Sudden-Onset Diabetes; Sudden-Onset Diabetes Mellitus; Diabetes Mellitus, Brittle; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Sudden-Onset; Diabetes, Autoimmune; IDDM

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Type 1 Diabetes Mellitus (Autoimmune Diabetes)
2.	Type 2 Diabetes Mellitus (MODY)
3.	Diabetes Mellitus
4.	Hypoglycemia (Reactive Hypoglycemia)
5.	Hyperglycemia
485 Diseases and 4056 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Huang, Gan: 7 articles (09/2007 - 11/2003)
2.	Chatenoud, Lucienne: 7 articles (04/2007 - 01/2002)
3.	Sanjeevi, C B: 7 articles (11/2003 - 08/2001)
4.	Bluestone, Jeffrey A: 6 articles (04/2007 - 10/2002)
5.	Chiarelli, F: 5 articles (10/2007 - 03/2000)
6.	Lernmark, A: 5 articles (05/2007 - 04/2000)
7.	Yang, Lin: 5 articles (12/2006 - 11/2003)
8.	Phillip, Moshe: 5 articles (08/2006 - 04/2003)
9.	Shtauvere-Brameus, A: 5 articles (04/2002 - 04/2002)
10.	Kobayashi, Tetsuro: 4 articles (06/2008 - 04/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Type 1 Diabetes Mellitus:

1.	Insulin (Novolin)FDA Link 08/01/1990 - "Therefore, most studies have failed to demonstrate improved glycemic control after adding sulfonylurea to insulin therapy in patients with insulin-dependent diabetes mellitus" 10/01/1993 - "Moreover, after the clinical onset of IDDM, most patients experience a transitory period of improved insulin secretion" 07/01/2002 - "CONCLUSION: Diabetic patients undergo an important oxidative stress that is nearly corrected for IDDM, but only partially improved for ITDM2, although length of insulin treatment and HbA1c values are similar, suggesting metabolic differences between the two types of diabetes." 12/01/1991 - "Insulin replacement is the mainstay of treatment in IDDM; however, optimal therapy requires a careful balance of food, insulin, and physical activity" 04/01/2006 - "BACKGROUND: The honeymoon period (i.e., partial remission) of type 1 diabetes mellitus is characterized by reduced insulin requirements while good glycemic control is maintained" Get all the results and reference details, order at left...
2.	Glucose (Dextrose)FDA LinkGeneric 03/01/1998 - "Significantly greater concentrations of glucose were seen in saliva and serum in children with IDDM" 07/01/1984 - "Normalization of glucose tolerance by means of GCIIS was associated with significant improvement of lipid metabolism in IDDM" 06/01/1997 - "The Glucose Evaluation Trial for Remission (GETREM): A European effort to evaluate insulin-dependent diabetes mellitus in the first year after diagnosis." 08/01/1984 - "Thus, the efficacy of the glucose counterregulatory systems determines the limits of intensive therapy of IDDM." 10/01/1983 - "A randomized, prospective study was performed to evaluate the efficacy of daily home glucose monitoring on the outcome of pregnancies in women with insulin-dependent diabetes mellitus" Get all the results and reference details, order at left...
3.	Blood Glucose (Blood Sugar)IBA 03/01/1989 - "Our data suggest that clinic-based problem-solving groups can be more effective with young adolescents with IDDM than conventional treatment in preventing the expected deterioration in blood glucose." 08/01/1998 - "In the present study, we have examined the effect of an improved blood glucose control on plasma levels of hydroperoxides in patients with IDDM" 06/01/1997 - "In patients with IDDM our studies demonstrated the limitations of traditional clinical judgement and the laboratory procedures in providing an accurate assessment of blood glucose control and that knowledge of HbA1c values allowed the clinician to identify patients in poor glycemic control and lead to improvement in glycemic control" 09/01/1996 - "Microangiopathy is retarded by improved blood glucose control in patients with IDDM" 08/01/1989 - "Improved blood glucose control, without 'near normoglycaemia', delayed the progression of nephropathy in patients with IDDM and retinopathy." Get all the results and reference details, order at left...
4.	C-PeptideIBA 07/01/1998 - "To investigate the role of puberty on spontaneous clinical remission and on secretion of residual C-peptide during the first year of type 1 diabetes mellitus, we studied 77 pre-pubertal, 39 pubertal and 41 post-pubertal type 1 diabetic patients" 01/01/1998 - "In addition, replacement of C-peptide during a period of 1-3 months has been shown to improve renal function as well as autonomic and sensory nerve function in IDDM patients" 01/01/2007 - "At present, in view of numerous studies concerning its structure, membrane binding and biological functions, C-peptide seems to constitute a crucial role in the pathogenesis of complications in diabetes mellitus type 1 (DM1)" 04/01/2005 - "Recent studies have demonstrated that replacement of C-peptide to normal physiological concentrations in IDDM patients either on a short-term basis (1-3 hours) or on a prolonged administration (1-3 months) was accompanied by improvements in renal glomerular and tubular function" 05/01/2004 - "METHODS: The study included 20 participants with C-peptide-deficient Type 1 diabetes mellitus" Get all the results and reference details, order at left...
5.	Cyclosporine (Ciclosporin)FDA LinkGeneric 09/01/1992 - "Several studies have demonstrated the efficacy of cyclosporin A in modifying the initial course of Type 1 (insulin-dependent) diabetes mellitus in older children and adults but none have reported the effects in very young children" 09/01/1987 - "We have developed a protocol of prophylactic cyclosporin A administration which confers complete and permanent protection against insulin-dependent diabetes mellitus in diabetes-prone BioBreeding rats" 09/01/1987 - "Cyclosporin A prophylaxis initiated later, but still before the onset of clinical symptoms (8-9 weeks), and terminated at 22-23 weeks, was only partially effective; 5/20 (25%) of cyclosporin A-treated rats developed insulin-dependent diabetes mellitus, compared to 60% (12/20) of controls (p less than 0.05)" 04/01/1988 - "The subjects were drawn from a pilot study (The Canadian Open Study on the effects of immunosuppression with Cyclosporine in Type 1 Diabetes Mellitus) in which 50% of the patients demonstrated remission during one year of cyclosporine administration" 05/01/1991 - "Endocrine-metabolic function in remission-phase IDDM during administration of cyclosporine." Get all the results and reference details, order at left...
6.	AntibodiesIBA 09/01/1996 - "Thus, p277 peptide therapy, marked by the induction of Th2-type antibodies, can be effective in toxin-induced autoimmune diabetes." 02/01/2006 - "CONCLUSIONS: Measurement of antigliadin antibodies in patients with diabetes mellitus type 1 helped in the selection of patients to undergo jejunal biopsy" 02/01/2003 - "In mouse models of autoimmune diabetes, CD3-specific antibodies induce stable disease remission by restoring tolerance to pancreatic beta-cells" 08/01/1996 - "Although the positivity was low, the detection of hsp60 antibodies may be helpful for diagnosis of IDDM especially in GAD65 Ab- or JCA-negative Japanese patients." 04/01/1980 - "Pancreatic islet-cell antibodies (I.C.Ab.) were detected in the sera of 6 of 123 patients with insulin-dependent diabetes mellitus of recent onset, compared with only 2 positive results among the 434 control sera" Get all the results and reference details, order at left...
7.	insulin LISPRO (Humalog)FDA Link 05/01/1999 - "Long-term efficacy of humalog in subjects with Type 1 diabetes mellitus." 08/01/1997 - "Strategies toward improved control during insulin lispro therapy in IDDM" 03/01/1997 - "Prolonged efficacy of short acting insulin Lispro in combination with human ultralente in insulin-dependent diabetes mellitus." 01/01/2003 - "Pregnancy outcome in Type 1 diabetes mellitus treated with insulin lispro (Humalog)." 11/01/2002 - "Insulin lispro therapy in pregnancies complicated by type 1 diabetes mellitus." Get all the results and reference details, order at left...
8.	Lipoproteins (Lipoprotein)IBA 12/01/1998 - "The comparison of examined groups showed statistically significant higher susceptibility on the oxidation of chosen lipoproteins in pregnant with IDDM" 07/01/1991 - "Abnormal clearance of postprandial Sf 100-400 plasma lipoproteins in insulin-dependent diabetes mellitus." 12/01/2001 - "In conclusion, children with type 1 diabetes mellitus included in this study did not have high-risk lipoprotein profiles at this early stage of life" 12/01/1998 - "OBJECTIVES AND DESIGN: The aim of study was estimation of susceptibility on the process of oxidation of selected lipoproteins of pregnant women with IDDM in II, III trimester of pregnancy" 05/01/1998 - "This study suggests that moderate alcohol consumption has no beneficial effect on the lipoprotein profile in IDDM men" Get all the results and reference details, order at left...
9.	Streptozocin (Streptozotocin)FDA Link 08/01/2007 - "In the present study, we investigated the effect of oral anti-CD3 mAb on the prevention of autoimmune diabetes in AKR mice in which the low-dose streptozocin (STZ) model induces autoimmunity to the beta-cells of the islets" 08/31/2005 - "The aim of this study is to investigate the redox status of peritoneal Mp and its cytokine profile during the development of autoimmune diabetes induced by multiple low-dose streptozotocin in BALB/c mice" 04/01/2001 - "The objectives of the present study were: (a) to investigate the effect of delta9-THC in an established model of multiple low dose streptozotocin (MLDSTZ)-induced autoimmune diabetes; and (b) to determine the contribution of the immune response in the MLDSTZ model" 01/01/2001 - "In the present study, the immunomodulatory potential of PTX was investigated in autoimmune diabetes induced by multiple low doses of streptozotocin (MLD-SZ) in genetically susceptible CBA/H mice (tested with 40 mg SZ/kg b.w" 07/01/1998 - "The present study examines two murine models of autoimmune IDDM, the nonobese diabetic (NOD) and the low-dose streptozotocin (stz) murine models for changes in the expression of glut2 by double-label light and confocal microscopy during various stages of the disease" Get all the results and reference details, order at left...
10.	Insulin-Like Growth Factor I (IGF-1)IBA 07/01/1996 - "Higher rate of clearance of the latter may be the reason for the low IGF-I levels we observed in children with IDDM" 07/01/1996 - "The role of recombinant human IGF-I in the treatment of IDDM needs to be tested by long-term controlled trials." 10/01/2003 - "The relationship between hPGH and IGF-I in type 1 diabetes mellitus has not been investigated thoroughly" 09/01/2003 - "The relationship between hPGH and IGF-I in type 1 diabetes mellitus has not been investigated thoroughly" 01/01/2002 - "We conclude that the microvascular reactivity is impaired in Type 1 diabetes mellitus, but this impairment is not clearly dependent on the activity of the IGF-I system" Get all the results and reference details, order at left...
1637 Drugs and Important Bio-Agents and 8533 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 11/01/1997 - "Successful transplantation could ultimately provide a cure for insulin-dependent diabetes mellitus" 11/15/2008 - "Parenteral administration of anti-CD3 monoclonal antibody is an approved therapy for transplantation in humans and is effective in autoimmune diabetes" 03/01/2007 - "Transplantation of pancreatic islets is a promising therapeutic treatment for type 1 diabetes mellitus" 03/01/2007 - "BACKGROUND: Simultaneous pancreas-kidney (SPK) transplantation is an effective treatment for patients suffering from type 1 diabetes mellitus" 06/01/2006 - "Parenteral administration of CD3-specific monoclonal antibody is an approved therapy for transplantation in humans and is effective in autoimmune diabetes" Get all the results and reference details, order at left...
2.	Islets of Langerhans Transplantation 08/01/2005 - "Improved human pancreatic islet isolation for a prospective cohort study of islet transplantation vs best medical therapy in type 1 diabetes mellitus." 03/27/1999 - "The findings have potential implications for islet transplantation as well as improved and more cost-effective therapy for IDDM." 02/01/2008 - "We conclude that in islet transplantation and autoimmune diabetes, ICOS blockade can be effective in inhibiting alloimmunity and preventing autoimmunity but is ineffective in inhibiting recurrence of autoimmunity." 04/27/1994 - "Islet transplantation can provide a therapeutic option for patients who suffer from type 1 diabetes mellitus, especially if current aggressive immunosuppression could be eliminated" 07/15/2003 - "BACKGROUND: New strategies for improving durable functional islet mass will be instrumental in facilitating islet transplantation as a cure for type 1 diabetes mellitus" Get all the results and reference details, order at left...
3.	Kidney Transplantation 12/01/1994 - "PKT has become an important option in selected IDDM patients being considered for kidney transplantation because of its ability to offer superior glycemic control and improved quality of life" 05/01/2005 - "BACKGROUND: Simultaneous pancreas-kidney transplantation (SPK) has evolved as an effective treatment for patients with end-stage nephropathy due to type 1 diabetes mellitus" 06/21/2002 - "BACKGROUND AND OBJECTIVE: The pancreas kidney transplantation (PKTx) currently is the only treatment for cure for patients with diabetes mellitus Type 1. Despite the availability of organs and the need for therapy the PK