|2.||Brain Edema (Cerebral Edema)
|3.||Brain Injuries (Brain Injury)
|5.||Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
|1.||Xi, Guohua: 63 articles (01/2016 - 01/2002)|
|2.||Keep, Richard F: 57 articles (01/2016 - 01/2002)|
|3.||Hua, Ya: 57 articles (01/2016 - 01/2002)|
|4.||Greenberg, Steven M: 34 articles (08/2015 - 07/2003)|
|5.||Rosand, Jonathan: 32 articles (08/2015 - 07/2003)|
|6.||Hua, Y: 31 articles (01/2010 - 01/2000)|
|7.||Keep, R F: 30 articles (01/2010 - 01/2000)|
|8.||Zhang, John H: 29 articles (01/2016 - 10/2004)|
|9.||Tang, Jiping: 29 articles (01/2016 - 10/2004)|
|10.||Xi, G: 28 articles (01/2010 - 01/2000)|
|1.||Tissue Plasminogen Activator (Alteplase)FDA Link
08/01/2003 - "One of the most important predictors of clinical success is time to treatment, with early treatment of <3 hours for intravenous tissue plasminogen activator and <6 hours for intra-arterial thrombolysis demonstrating significant improvement in terms of 90-day clinical outcome and reduced cerebral hemorrhage. "
09/01/2014 - "We investigated which definition best identifies cerebral hemorrhages that alter long-term functional outcome in the National Institute of Neurological Disorders and Stroke (NINDS) tissue-type plasminogen activator (tPA) trials. "
08/01/2013 - "A previous study showed the iScore can predict clinical response and risk of intracerebral hemorrhage (ICH) after administration of tissue plasminogen activator (tPA). "
06/01/2006 - "A recent study showed a dramatic increase in cerebral hemorrhage comprising atypical locations with low-frequency ultrasound-mediated recombinant tissue plasminogen activator-thrombolysis in humans. "
12/15/2015 - "Our data show no excess risk of cerebral hemorrhage in patients with NIHSS score >25 compared to score 15-25, suggesting that the European contraindication to IV tissue plasminogen activator treatment at NIHSS levels >25 may be unwarranted. "
|2.||Heparin (Liquaemin)FDA LinkGeneric
05/25/2001 - "We investigated the efficacy of heparin on cerebral ischemic damage in a rabbit model of middle cerebral artery (MCA) photothrombosis and in the same model, cerebral hemorrhage induced by heparin as its side effect was also investigated. "
05/01/2010 - "Iodinated radiographic contrast material effect may be additive to heparin effect on the incidence of cortical intracerebral hemorrhage."
05/01/2010 - "Intraarterial iodinated radiographic contrast material may increase cortical intracerebral hemorrhage, similar to heparin. "
05/01/2010 - "Similar trends for increased cortical intracerebral hemorrhage were seen in the contrast-only (P=0.18) and heparin-only (P=0.18) groups. "
05/01/2010 - "Both pooled contrast groups (85.7%) and pooled heparin groups (88.9%) had higher rates of cortical intracerebral hemorrhage compared with the control group (P<0.05). "
|3.||Warfarin (Coumadin)FDA LinkGeneric
12/15/2015 - "A multicenter, prospective, observational study of warfarin-associated intracerebral hemorrhage: The SAMURAI-WAICH study."
09/01/2011 - "Effect of increased warfarin use on warfarin-related cerebral hemorrhage: a longitudinal population-based study."
05/01/2009 - "The challenge of designing a treatment trial for warfarin-associated intracerebral hemorrhage."
01/13/2009 - "This study suggests that underlying microbleeds are independently associated with an incidence of warfarin-related intracerebral hemorrhage. "
09/01/2015 - "One of the independent predictors of intracerebral hemorrhage is the presence of cerebral microbleeds (CMBs); a high incidence of intracerebral hemorrhage is reported in warfarin-treated patients with multiple CMBs. "
|4.||Glucose (Dextrose)FDA LinkGeneric
07/01/1989 - "Intravenous administration of foridone (1 microgram/kg/min) to cats one day after intracerebral hemorrhage produced a significant improvement of blood supply to the brain, glucose utilization by the brain, a moderate increase of oxygen consumption."
01/01/1999 - "Five pretreatment variables (P<0.1 univariate analysis), including serum glucose (>300 mg/dL), predicted symptomatic intracerebral hemorrhage (ICH) in the National Institute of Neurological Disorders and Stroke rtPA trial. "
03/01/2014 - "Effect of increased glucose levels on short-term outcome in hypertensive spontaneous intracerebral hemorrhage."
07/01/2011 - "Severity of intraventricular extension correlates with level of admission glucose after intracerebral hemorrhage."
01/01/2011 - "Effects of early serum glucose levels on prognosis of patients with acute intracerebral hemorrhage."
|5.||atorvastatin (Lipitor)FDA Link
01/01/2015 - "Two potent inhibitors were proven effective in inhibiting the phosphorylation of the downstream target in the ROCK signaling pathway in vitro and protecting atorvastatin-induced cerebral hemorrhage in vivo. "
07/01/2004 - "Improvement in neurological outcome after administration of atorvastatin following experimental intracerebral hemorrhage in rats."
06/01/2013 - "We evaluated the neuroprotective effects of atorvastatin (2, 5, and 10 mg/kg) on experimentally induced intracerebral hemorrhage (ICH) in adult rats; controls were administered PBS. "
06/01/2013 - "In addition, the pharmacological effect of the two ROCK1 inhibitors with novel scaffolds on atorvastatin-induced cerebral hemorrhage was evaluated by using zebrafish model, and one compound candidate is able to prevent atorvastatin-induced cerebral hemorrhage effectively."
01/01/2012 - "Effects of atorvastatin on pathological changes in brain tissue and plasma MMP-9 in rats with intracerebral hemorrhage."
|6.||recombinant FVIIa (rFVIIa)IBA
04/01/2008 - "Alternatively, rFVIIa, has shown promising results in the management of spontaneous intracerebral hemorrhage. "
01/01/2013 - "The ethics of allowing off-protocol access to a study therapy are explored, using the example of recombinant factor VIIa for intracerebral hemorrhage. "
04/01/2008 - "These procedures will be explained using the example of the recombinant factor VIIa (rFVIIa) trials for intracerebral hemorrhage."
03/01/2008 - "Risk of thromboembolic events in controlled trials of rFVIIa in spontaneous intracerebral hemorrhage."
01/01/2008 - "Phase I/II placebo-controlled clinical trials of recombinant Factor VIIa (rFVIIa) suggested that administration of rFVIIa within 4 hours after onset of intracerebral hemorrhage (ICH) is safe, limits ICH growth, and improves outcomes. "
|7.||Interleukin-6 (Interleukin 6)IBA
08/01/2008 - "On the basis of medication, cranial needling can promote rapid decrease of serum IL-6 content and improve nervous function in the patient of acute cerebral hemorrhage."
08/01/2008 - "[Effect of cranial needling combined with medicine on IL-6 in the patient of acute cerebral hemorrhage]."
01/01/2008 - "Serum IL-6 and CRP level increases in the first days after intracerebral hemorrhage. "
01/01/2010 - "The association between the plasmatic IL-6 levels, severity of trauma according to the Glasgow Coma Scale, volume of intracerebral hemorrhage and patient's clinical evolution were investigated. "
01/01/2010 - "Interleukin-6 plasmatic levels in patients with head trauma and intracerebral hemorrhage."
|8.||Dexamethasone (Maxidex)FDA LinkGeneric
10/01/2009 - "These results indicate that a 1-mg/kg dose of dexamethasone is beneficial for treatment of intracerebral hemorrhage, particularly if administered early after the hemorrhagic insult."
05/14/1987 - "To evaluate the efficacy of dexamethasone for treatment of primary supratentorial intracerebral hemorrhage, we studied 93 patients 40 to 80 years old, using a double-blind randomized block design. "
02/14/2007 - "This study investigated whether dexamethasone (DEX) treatment could regulate the expression of aquaporin-4 (AQP4) in rats with intracerebral hemorrhage (ICH). "
01/01/2015 - "Dexamethasone reduces brain cell apoptosis and inhibits inflammatory response in rats with intracerebral hemorrhage."
02/14/2007 - "Dexamethasone treatment modulates aquaporin-4 expression after intracerebral hemorrhage in rats."
12/01/2011 - "The same dose of curcumin also significantly attenuated neurological deficits at 1 and 3 days of intracerebral hemorrhage (p<0.05). "
12/01/2011 - "Curcumin (150 mg/kg) was administered 15 min after intracerebral hemorrhage. "
12/01/2011 - "We, therefore, investigated the pre-clinical effect of curcumin treatment on neurological outcomes following intracerebral hemorrhage, using a mouse model. "
12/01/2011 - "However, the effect of curcumin on intracerebral hemorrhage remains unclear. "
12/01/2011 - "Neuroprotection and sensorimotor functional improvement by curcumin after intracerebral hemorrhage in mice."
01/01/2016 - "To determine the relation between high arterial oxygen tension levels (PaO2) and long-term mortality in patients with spontaneous intracerebral hemorrhage treated in the ICU. "
01/01/2016 - "Association Between High Arterial Oxygen Tension and Long-Term Survival After Spontaneous Intracerebral Hemorrhage."
11/19/2015 - "Hyperbaric oxygen preconditioning attenuates neuroinflammation after intracerebral hemorrhage in rats by regulating microglia characteristics."
01/01/2015 - "In major insults to the brain (e.g., intracerebral hemorrhage), a slight decrease in oxygen supply, as occurs in a hypobaric environment at high altitude, has devastating effects on the injured brain tissue. "
12/01/2014 - "To investigate the effects of different atmosphere absolutes (ATA) of high-pressure oxygen (HPO) on brain tissue water content and Aquaporin-4 (AQP4) expression in rabbits with cerebral hemorrhage. "
|1.||Transplantation (Transplant Recipients)
01/01/2014 - "Our data suggest that the use of neural stem cells in intrathecal transplantation for the treatment of cerebral hemorrhage is safe and effective."
01/01/2015 - "Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell Transplantation for Treatment of Intracerebral Hemorrhage."
10/01/2012 - "Transplantation of adipose-derived stem cells is associated with neural differentiation and functional improvement in a rat model of intracerebral hemorrhage."
01/01/2014 - "In this study, we aimed to explore the curative effect and safety of neural stem cell intrathecal transplantation for the treatment of cerebral hemorrhage. "
05/01/2011 - "Bone marrow stromal cell (BMSC) transplantation influences functional outcome subsequent to intracerebral hemorrhage (ICH), and enhances endogenous neurogenesis in acute condition studies. "
12/01/1998 - "In clinical trials, patients treated with thrombolytic therapy have shown a 6% rate of intracerebral hemorrhage, which was balanced against a 30% improvement in functional outcome over controls. "
04/22/1998 - "Physicians in this study did not uniformly achieve a level of sensitivity for identification of intracerebral hemorrhage sufficient to permit safe selection of candidates for thrombolytic therapy."
01/01/2014 - "Adverse events including intracerebral hemorrhage and reperfusion arrhythmias are well known to occur with thrombolytic therapy. "
10/01/2012 - "However, the use of thrombolytic therapy is associated with an increased risk of symptomatic intracerebral hemorrhage (sICH). "
06/01/2011 - "Future perspectives on the fibrinolytic therapy of intracerebral hemorrhages."
11/01/2014 - "The intracerebral hemorrhage drainage through minimally invasive approach is emerging as an alternative for traditional craniotomy, due to its improved survival rate and reduced complication rate. "
12/01/2012 - "One case of cerebral hemorrhage after surgery was cured with craniotomy, followed for 2 years without recurrence. "
01/01/2014 - "The MISTICH trial is a randomized controlled trial designed to determine whether minimally invasive surgeries could improve the prognosis for patients with spontaneous intracerebral hemorrhage compared with craniotomy. "
01/01/2014 - "Stereotactic aspiration versus craniotomy for primary intracerebral hemorrhage: a meta-analysis of randomized controlled trials."
01/01/2011 - "A prospective controlled study: minimally invasive stereotactic puncture therapy versus conventional craniotomy in the treatment of acute intracerebral hemorrhage."
|4.||Drug Therapy (Chemotherapy)
09/01/2015 - "Among these 15 patients, 13 attained complete remission (CR) following induction chemotherapy, and two died of intracerebral hemorrhage during leukapheresis and induction chemotherapy, respectively. "
07/01/2015 - "However, the patient developed bone marrow depression during chemotherapy and died of massive cerebral hemorrhage after the first cycle of chemotherapy. "
09/01/2014 - "[Animal models of intracerebral hemorrhage for development of new drug therapy]."
01/01/2010 - "Exploring neuroprotective drug therapies for intracerebral hemorrhage."
12/01/2009 - "There are few data on the effectiveness and side effects of antiepileptic drug therapy after intracerebral hemorrhage. "
|5.||Chinese Traditional Medicine (Traditional Chinese Medicine)
04/01/2011 - "Scalp acupuncture (SA) is a commonly used therapeutic approach for primary intracerebral hemorrhage (ICH) in Traditional Chinese Medicine (TCM), but the efficacy and safety of SA therapy are still undetermined. "
02/28/2002 - "To investigate the protective effects and mechanisms of the traditional Chinese medicine complex, nao-yi-an granule (NYA) on experimental intracerebral hemorrhage (ICH) in rats. "
12/28/2000 - "To explore the neuronal protective effects of a traditional Chinese medicine complex Nao-Yi-An granule(NYA) on experimental intracerebral hemorrhage(ICH) in rats. "
01/01/1997 - "The potential inhibitory effect on NDP induction by Nao Yi An (NYA), a complex derived from materials of animal and plant origin used in the treatment of intracerebral hemorrhage in traditional Chinese medicine, was also investigated. "
10/31/2012 - "Naodesheng prescription is a widely used traditional Chinese medicine (TCM), and mainly applied in clinics to treat cerebral arteriosclerosis, ischemic stroke, sequelae of cerebral hemorrhage etc. The present study was designed to investigate the anti-thrombosis effects of this prescription, and to search its bioactive fraction. "