Pathologic Processes

1.	Piruzian, L A: 2 articles (03/2002 - 03/2000)
2.	Saprin, A N: 2 articles (03/2002 - 03/2000)
3.	Sukhanov, V A: 2 articles (03/2002 - 03/2000)
4.	Hu, Yinghui: 1 article (04/2008)
5.	Russek, Shelley J: 1 article (04/2008)
6.	Hernandez-Blazquez, Francisco Javier: 1 article (08/2007)
7.	Dagli, Maria Lúcia Zaidan: 1 article (08/2007)
8.	Zaidan Dagli, Maria Lúcia: 1 article (08/2007)
9.	Vasilenko, O I: 1 article (07/2007)
10.	Malenchenko, A F: 1 article (07/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pathologic Processes:

1.	Reactive Oxygen Species (Oxygen Radicals)IBA 08/14/2009 - "Reactive oxygen species (ROS) are constantly generated and eliminated in the biological system and play important roles in a variety of physiological and pathological processes. " 04/01/2004 - "Reactive oxygen species (ROS) are constantly generated and eliminated in the biological system, and play important roles in a variety of normal biochemical functions and abnormal pathological processes. " 08/15/2009 - "Advances in sensor technologies have enhanced our understanding of the roles played by reactive oxygen species (ROS) in a number of physiological and pathological processes. " 01/01/2009 - "Reactive oxygen species (ROS) regulate both normal cell functions by activating a number of enzymatic cascades and pathological processes in many diseases by inducing oxidative stress. " 02/22/2008 - "Moreover, we discovered that meIA-2 is self-proteolyzed in vitro by reactive oxygen species, suggesting the possibility of a new shedding mechanism that might be significant in normal function or pathological processes. " Order ALL the reference details at left...
2.	CytokinesIBA 11/01/1999 - "The study of plasma cytokine levels is also of limited value, and complementary methods are now available to investigate and understand more precisely the involvement of cytokines in pathological processes." 07/01/1999 - "CONCLUSION: This study demonstrates that, even in apparently healthy subjects, age-associated immune activation indicated by raised levels of pro-inflammatory cytokines may reflect age-associated pathological processes that develop over decades." 08/01/2009 - "Discussions about various physiological and pathological processes commonly debate the role of mediators known as cytokines. " 09/01/2007 - "Inflammatory cytokines released from adipose tissue play an important role in different pathological processes. " 08/01/2006 - "Over recent years, with many advances in understanding the pathological processes that underlie many inflammatory conditions, it has become clear that targeting cytokines has proven to be highly effective therapeutically. " Order ALL the reference details at left...
3.	CollagenIBA 09/01/1982 - "It is suggested that this antibody will be of value in research on the structure of human basement membrane collagen, on the distribution of this collagen in various basement membranes, and particularly for the study of basement membranes in normal human development and pathologic processes." 09/25/2009 - "Collagen, known for its structural role in tissues and also for its participation in the regulation of homeostatic and pathological processes in mammals, is assembled from triple helices that can be either homotrimers or heterotrimers. " 09/01/2008 - "Collagen is responsible for maintenance of connective tissue integrity, and through interaction with integrin receptors may participate in regulation of numerous physiological and pathological processes. " 11/15/2002 - "Degradation of the basement membrane collagens occurs during numerous physiological and pathological processes such as embryonic development or tumorigenesis and generates collagen fragments. " 09/01/2002 - "The cellular events leading to abnormal synthesis of collagen are important to our understanding of pathologic processes leading to impaired joint function. " Order ALL the reference details at left...
4.	Arginine (L-Arginine)FDA Link 01/01/2008 - "Protein arginine methylation is a rapidly growing field of biomedical research that holds great promise for extending our understanding of developmental and pathological processes. " 04/01/2009 - "Thus, protein arginine methylation is critical for regulation of transcription and potentially for various physiological/pathological processes." 08/01/1997 - "To prevent or treat these pathological processes, in which a deficiency in vascular NO formation plays a causative role, NO may be provided through methods such as direct NO administration or indirect NO supply through either NO donors or L-arginine, which facilitates NO formation." 12/01/1983 - "Depressed arginine plasma levels were detectable before any of the biochemical or pathological processes co-examined and as such may prove useful as a sensitive in vivo method for detection of acute liver damage." 01/01/2009 - "Nitric oxide is a free radical molecule synthesized from L-arginine by nitric oxide synthases that plays a critical role in various physiological and pathological processes, including tumor growth and angiogenesis. " Order ALL the reference details at left...
5.	AH 1058IBA 06/09/2000 - "These results suggest that AH-1058 can become a long-acting Ca(2+) channel blocker with unique antiarrhythmic properties, and that AH-1058 may be used in certain pathological processes, for which selective inhibition of the cardiac Ca(2+) channels is essential." 01/01/2001 - "This unique cardiovascular profile of AH-1058 is expected to be useful in the treatment of certain pathological processes such as the obstructive hypertrophic cardiomyopathy, vasovagal syncope, dissecting aortic aneurysm, and ventricular arrhythmias, in which selective inhibition of the ventricular Ca2+ channels is essential for drug therapy." 05/01/2000 - "These results suggest that this unique cardiovascular profile of AH-1058 may become beneficial for the treatment of certain pathologic processes, in which selective inhibition of ventricular calcium channels would be essential for drug therapy." Order ALL the reference details at left...
6.	Peptide Hydrolases (Proteases)IBA 01/01/2007 - "In this review, we discuss the development and applications of activity based probes (ABPs) to study proteases and their role in pathological processes. " 01/01/2001 - "Current and future studies on this emerging group of ECM proteases may provide important insights into developmental or pathological processes involving ECM remodeling." 01/01/1992 - "Further studies of their regulation will be important to define the roles of these proteinases in physiologic and pathological processes." 01/01/1986 - "Many of these studies were prompted by findings that interactions of these proteases with cells and the extracellular matrix are important in a number of physiologic and pathologic processes. " 01/01/2009 - "Proteolytic enzymes play an essential role in many biological and pathological processes. " Order ALL the reference details at left...
7.	OxygenIBA 01/01/1989 - "Finally, oxygen dissociation curves in single red blood cells can be obtained by means of particular flow cell, with promising results for the study of physiological and pathological processes (namely red cell sickling in drepanocytosis)." 11/01/2008 - "Mechanisms of oxygen sensing and regulation underlie many physiological and pathological processes, and only a handful of oxygen regulators have been identified in previous studies. " 01/01/2008 - "Study of Hb-DNIC interaction with reactive oxygen metabolites is important for understanding NO and Hb roles in pathological processes that could result from oxidative stress." 01/01/2009 - "Rheological conditions basically influence tissue perfusion, oxygen and nutrient supply, tissue regeneration and in its consequence the course of pathological processes, especially in microcirculation and partially even in macrocirculation. " 11/01/2007 - "The ability of cells to respond to changes in oxygen availability is critical for many physiological and pathological processes (i.e. " Order ALL the reference details at left...
8.	Retinaldehyde (Retinal)IBA 07/01/2009 - "CONCLUSIONS: The method of OCT acquisition and analysis used in this study allows for greater spatial localization of change in retinal thickness associated with aging or pathological processes. " 03/01/1989 - "This cell line may be useful for studies of human retinal cell development and metabolism, and responses to pathological processes." 07/07/2006 - "Characterization of these 355 genes provided insight into physiologic and pathologic processes of mouse retinal development during the second and third postnatal weeks, a period that corresponds to human embryogenesis between weeks 12 and 28. " 11/01/1998 - "In ordinary somatic cells (e.g., endothelial or retinal cells) this activation disturbs the metabolism of these cells, whereas a transition into an "excited state" of effector cells such as monocytes or polymorphonuclear leukocytes causes an avalanche-like increase of various pathological processes damaging the body. " 01/15/1989 - "Microscopic retinal and optic disk pathologic processes also were suspected. " Order ALL the reference details at left...
9.	Matrix MetalloproteinasesIBA 12/01/2009 - "Evidence exists concerning the role of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in mediating normal and pathological processes, including HGF. " 11/15/2009 - "Cellular remodeling of the extracellular matrix (ECM), an essential component of many physiological and pathological processes, is dependent on the trafficking and secretion of matrix metalloproteinases (MMPs). " 01/01/2009 - "In fact, MMPs regulate many biological processes, being involved not only in physiological events, but also in pathological processes. " 09/01/2008 - "BACKGROUND: Matrix metalloproteinases (MMPs) and transforming growth factor-beta1 (TGF-beta1) are important in many physiological and pathological processes. " 04/01/2008 - "Matrix metalloproteinases (MMPs) play an important role in many physiological and pathological processes. " Order ALL the reference details at left...
10.	Biological Markers (Surrogate Marker)IBA 12/01/2000 - "The BPF is an informative surrogate marker for destructive pathological processes in relaping MS patients, and is useful in demonstrating treatment effects in controlled clinical trials. " 10/01/2009 - "Here, we review available CSF biomarkers for these pathological processes. " 01/01/2009 - "PURPOSE: Biomarkers are molecular mediators that can serve as indicators of normal biological processes, pathologic processes, and therapeutic interventions. " 11/01/2008 - "But for the fundamental treatment based on background pathological processes, surrogate biomarkers, including structural and functional neuroimages and findings of cerebrospinal fluid, blood and urine, should be pursued for future progress in FTD research." 10/01/2008 - "Biochemical markers of bone turnover provide clinically useful evidence of the normal and pathologic processes that reflect bone cell activity in the skeleton. " Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 02/09/2001 - "This unique cardiovascular profile may be beneficial for the treatment of certain pathological processes in which selective inhibition of the ventricular Ca(2+)channels would be the target of drug therapy." 01/01/1968 - "[Topical drug therapy of pathologic processes in the mouth complicated by changes in the oral pH]" 11/01/1992 - "Substances secreted by strains-producers, are capable to suppress the growth of pathogenic microflora and malignant tumors as well as to correct physiological and pathological processes, may be utilized in future for a microbial saprotrophic pharmacotherapy depending on indications." 10/01/2003 - "The results of combined therapy of chronic moderate generalized periodontitis can be improved by adding richlocaine to protocols of drug therapy: the drug reduces the time of treatment, prolongs remission, decreases the number of relapses, and stabilizes pathological processes in periodontal tissues." 01/01/2001 - "This unique cardiovascular profile of AH-1058 is expected to be useful in the treatment of certain pathological processes such as the obstructive hypertrophic cardiomyopathy, vasovagal syncope, dissecting aortic aneurysm, and ventricular arrhythmias, in which selective inhibition of the ventricular Ca2+ channels is essential for drug therapy." Order ALL the reference details at left...
2.	Prostheses and Implants (Prosthesis) 06/01/2009 - "The additional information provided by 3D study was very useful for evaluation of mitral valve disease and mitral valve prostheses, enabling quick and reliable recognition of the cardiac anatomy and the pathological processes involved in each case. " 02/09/1999 - "The association between prosthesis-induced local pathological processes and redo valve size was investigated. " 04/01/1992 - "No pathologic processes were observed as a result of use of the prosthesis. " 08/01/1991 - "Part I of this review discusses the pathologic processes responsible for degeneration of porcine prostheses: intrinsic calcification (mineralization), cuspal tears and perforations, and cuspal thrombosis (non-infective). " 07/01/2009 - "Prosthesis dysfunction includes a group of pathological processes like thrombosis, thromboemboli, valvular or paravalvular regurgitation, patient-prosthesis mismatch, infective endocarditis and bioprosthesis degeneration. " Order ALL the reference details at left...
3.	Therapeutics 04/01/2006 - "Progress in the discovery and development of novel therapeutics benefits from a healthy alliance with, and the output from, more basic research institutions, and the reverse is also true, with many advances in understanding of physiological and pathological processes being as the result of the application of novel targeted molecules. " 05/01/2003 - "With increased understanding of the pathologic processes involved in these disorders, new therapeutics have arisen and are being investigated in the various subtypes of spondyloarthropathy. " 12/01/2001 - "As such, elucidating the structure-function and mechanism of the Bcl-2 family is important for understanding some of the fundamental principles underlying the death and survival of cells and of practical value for developing potential therapeutics to control apoptosis in pathological processes. " 08/01/2001 - "Understanding of the molecular basis of these effects may provide the means to develop novel therapeutics to control pathological processes associated with aberrant cell-extracellular matrix interactions." 08/01/2008 - "The quest for novel therapies for unipolar depression and bipolar disorder has generally centered on two complementary approaches: (1) understanding the presumed therapeutically relevant biochemical targets of currently available medications, and using that knowledge to design new drugs directed at both direct biochemical targets and downstream targets that are regulated by chronic drug administration; and (2) developing pathophysiological models of the illness to design therapeutics to attenuate or prevent those pathological processes. " Order ALL the reference details at left...
4.	Intensive Care (Surgical Intensive Care) 01/01/1990 - "Perhaps where the need for correct nutrition is most noted is in those patients who must undergo or support prolonged fasting or stress situations due to serious pathological processes, major surgery, etc., or patients with certain deteriorated clinical conditions, such as alterations to intestinal mobility, diminution of enzymatic secretion, neoplasic processes, etc. These are the patients whom we will encounter particularly in Digestive Surgery and in Reanimation or Intensive Care Services. " 09/01/1996 - "Assessment of the relationship between the total system and local pathological processes in patients with grave combined thoracic injuries and analysis of the efficacy of various therapeutic measures included in the intensive care complex brought the authors to a conclusion about the efficacy of surgical interventions, including repair of the thoracic carcass, in the early periods after the injury. " Order ALL the reference details at left...
5.	Urinary Diversion (Ileal Conduit) 12/01/2004 - "CONCLUSIONS: Bladder neck closure with simultaneous urinary diversion is a highly effective, well tolerated treatment for many pathological processes of the LUT. " Order ALL the reference details at left...

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