Tranexamic Acid (AMCA)

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657 relevant articles (74 outcomes, 104 trials/studies) found for this Drug

Description: Antifibrinolytic hemostatic used in severe hemorrhage.

Also Known As:

AMCA; Cyklokapron; AMCHA; Abbott Brand of Tranexamic Acid; Amchafibrin; Anvitoff; Exacyl; Fides Ecopharma Brand of Tranexamic Acid; KABI 2161; Pharmacia Brand of Tranexamic Acid; Pharmygiène Brand of Tranexamic Acid; Sanofi Synthelabo Brand of Tranexamic Acid; Spotof; Transamin; Ugurol; t-AMCHA; trans-4-(Aminomethyl)cyclohexanecarboxylic Acid; Acid, Tranexamic; Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-

Relationship Network

Drug Context: Research Results

Organic Chemicals: 42

Carboxylic Acids: 62

Carbocyclic Acids

Cyclohexanecarboxylic Acids

Tranexamic Acid: 657

cetraxate: 34

PKSI 527: 3

4-aminomethylcyclohexanecarbonyl-O-2-bromobenzyloxycarbonyltyrosine 4-acetylanilide

cetraxate benzyl ester

cis-4-aminomethylcyclohexane-1-carboxylic acid

tranexamic acid isobenzedrine ester

Experts

1.	Asakura, Hidesaku: 5 articles (12/2007 - 06/2004)
2.	Nakao, Shinji: 4 articles (11/2005 - 06/2004)
3.	Zarrabeitia, Roberto: 3 articles (04/2007 - 06/2004)
4.	Ontachi, Yasuo: 3 articles (11/2005 - 10/2004)
5.	Morishita, Eriko: 3 articles (09/2005 - 06/2004)
6.	Yamazaki, Masahide: 3 articles (09/2005 - 06/2004)
7.	Sethna, Navil F: 2 articles (09/2007 - 04/2005)
8.	Shapiro, Frederic: 2 articles (09/2007 - 04/2005)
9.	Zurakowski, David: 2 articles (09/2007 - 04/2005)
10.	Morales-Angulo, Carmelo: 2 articles (04/2007 - 02/2007)

Related Diseases

1.	Hemorrhage 03/01/2004 - "AIM: Prophylactic administration of tranexamic acid decreases bleeding and transfusions after cardiac procedures but it is still unclear what the best dose and the most appropriate timing to get the best results are. " 09/07/1996 - "CONCLUSIONS: Tranexamic acid given during menstruation is a safe and highly effective treatment for excessive bleeding. " 07/01/2003 - "BACKGROUND: In a pilot, non-randomized trial we tested the efficacy of tranexamic acid (TXA), a potent fibrinolytic inhibitor, as adjunctive therapy in standard treatment of major upper gastrointestinal bleeding in dialysis patients. " 01/01/1984 - "The study indicates that AMCA affords good protection against late bleeding in conisatio colli uteri." 05/01/2006 - "CONCLUSION: Topical application of tranexamic acid in patients undergoing primary open heart surgery led to a significant reduction of both postoperative mediastinal bleeding, and rate of re-exploration for haemostasis." Order ALL the reference details at left...
2.	Postoperative Hemorrhage 04/01/2004 - "Regarding time-related changes of postoperative blood loss, significant reduction was observed during the first 2 h after surgery in the tranexamic acid group ( P<0.001). " 07/01/1993 - "The authors thus conclude that antifibrinolytic therapy during CPB with tranexamic acid reduces postoperative blood loss, and shortens the operation time due to an improvement in hemostasis." 06/01/2009 - "Twenty-four-hour postoperative blood loss was significantly less in the tranexamic acid group compared with the control group (471 +/- 182 v 844 +/- 303). " 08/01/2007 - "Postoperative blood loss was significantly less in the tranexamic acid group compared to the control group (320 +/- 38 vs 480 +/- 75 mL). " 08/01/2005 - "There are conflicting results in the literature about tranexamic acid (TA) infusion in reducing postoperative blood loss and the number of transfused red cells (RBC) units. " Order ALL the reference details at left...
3.	Menorrhagia 05/01/1995 - "CONCLUSIONS: Tranexamic acid is a safe and effective form of medical therapy in women with menorrhagia and is highly likely to normalise blood loss in women losing 80 to 200 ml prior to treatment. " 01/01/2003 - "Nevertheless, tranexamic acid may be considered as a first-line treatment for the initial management of idiopathic menorrhagia, especially for patients in whom hormonal treatment is either not recommended or not wanted." 01/01/2003 - "In conclusion, the oral antifibrinolytic drug tranexamic acid is an effective and well tolerated treatment for idiopathic menorrhagia. " 10/01/2005 - "CONCLUSION: Tranexamic acid is a safe and effective form of medical therapy in women with menorrhagia; also increases quality of life in these women." 10/01/2005 - "OBJECTIVE: To determine the efficacy of tranexamic acid in the treatment of idiopathic menorrhgia and to investigate the effect of medical treatment with tranexamic acid on the quality of life of the women with idiopathic menorrhagia. " Order ALL the reference details at left...
4.	Neoplasms (Cancer) 04/01/1998 - "She was treated successfully with tranexamic acid and cryoprecipitate, until the tumor progressed and hyperfibrinogenolysis progressed to diffuse intravascular coagulation. " 01/01/1982 - "These seem to contribute to the significant reduction of tumor growth rate by AMCHA in combination with an anticancer drug compared to control." 04/15/2006 - "METHODS: During a 6-month trial period, 14 patients with spine cancer undergoing palliative intralesional tumor excision and concomitant instrumentation to stabilize the spine in the hands of a single surgeon were administered tranexamic acid intraoperatively in the attempt to minimize operative blood loss. " 04/15/2006 - "Tranexamic acid for hemostasis in the surgical treatment of metastatic tumors of the spine." 12/01/2004 - "CONCLUSION: The enhancement ratio of 1.4-1.7 for the L44 tumor, but not for the MLL tumor, due to AMCA treatment, indicates that AMCA may potentiate the anti-tumor effect of ionizing radiation in distinct tumor types." Order ALL the reference details at left...
5.	Scoliosis 04/01/2009 - "Tranexamic acid (TXA) has been investigated in these patient groups but consensus with respect to the dosing regimen has not been achieved, especially in the pediatric scoliosis literature. " 04/01/2005 - "CONCLUSION: Intraoperative administration of tranexamic acid significantly reduces blood loss during spinal surgery in children with scoliosis." 04/01/2005 - "Tranexamic acid reduces intraoperative blood loss in pediatric patients undergoing scoliosis surgery." 04/01/2009 - "Perioperative blood transfusion requirements in pediatric scoliosis surgery: the efficacy of tranexamic acid." 07/01/2001 - "A randomized trial of tranexamic acid to reduce blood transfusion for scoliosis surgery." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Aprotinin (Trasylol)
2.	Tranexamic Acid (AMCA)
3.	6-Aminocaproic Acid (6 Aminocaproic Acid)
4.	Levonorgestrel (Plan B)
5.	Antifibrinolytic Agents (Antifibrinolytics)
6.	Aminocaproic Acids (EAC)
7.	recombinant FVIIa (rFVIIa)
8.	Iron
9.	Deamino Arginine Vasopressin (Desmopressin)
10.	Plasmin (Fibrinolysin)

Related Therapies and Procedures

1.	Blood Transfusion (Blood Transfusions)
2.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
3.	Arthroplasty
4.	Platelet Transfusion (Blood Platelet Transfusions)
5.	Intrauterine Devices (Intrauterine Device)

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