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Cerebral Hemorrhage

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Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.

Also Known As:

Hemorrhage, Cerebrum; Brain Hemorrhages, Cerebral; Cerebral Brain Hemorrhage; Cerebral Brain Hemorrhages; Cerebral Hemorrhages; Cerebral Parenchymal Hemorrhages; Cerebrum Hemorrhage; Cerebrum Hemorrhages; Hemorrhage, Cerebral Brain; Hemorrhage, Cerebral Parenchymal; Hemorrhage, Intracerebral; Hemorrhages, Cerebral; Hemorrhages, Cerebral Brain; Hemorrhages, Cerebral Parenchymal; Hemorrhages, Cerebrum; Hemorrhages, Intracerebral; Intracerebral Hemorrhages; Parenchymal Hemorrhage, Cerebral; Parenchymal Hemorrhages, Cerebral; Brain Hemorrhage, Cerebral; Cerebral Parenchymal Hemorrhage; Hemorrhage, Cerebral; Intracerebral Hemorrhage

Networked: 1894 relevant articles (64 outcomes, 206 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Stroke (Strokes)
2.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
3.	Brain Edema (Cerebral Edema)
4.	Cerebral Infarction
5.	Alzheimer Disease (Alzheimer's Disease)

Experts

1.	Hua, Y: 31 articles (01/2010 - 01/2000)
2.	Xi, Guohua: 30 articles (02/2010 - 01/2002)
3.	Keep, R F: 30 articles (01/2010 - 01/2000)
4.	Keep, Richard F: 28 articles (02/2010 - 01/2002)
5.	Xi, G: 28 articles (01/2010 - 01/2000)
6.	Hua, Ya: 26 articles (02/2010 - 01/2002)
7.	Hoff, J T: 20 articles (01/2008 - 01/2000)
8.	Steiner, Thorsten: 17 articles (06/2010 - 01/2005)
9.	Hoff, Julian T: 17 articles (10/2007 - 01/2002)
10.	Mayer, Stephan A: 16 articles (04/2010 - 04/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cerebral Hemorrhage:

1.	Heparin (Liquaemin)FDA LinkGeneric 05/25/2001 - "We investigated the efficacy of heparin on cerebral ischemic damage in a rabbit model of middle cerebral artery (MCA) photothrombosis and in the same model, cerebral hemorrhage induced by heparin as its side effect was also investigated. " 05/01/2010 - "Iodinated radiographic contrast material effect may be additive to heparin effect on the incidence of cortical intracerebral hemorrhage." 05/01/2010 - "CONCLUSIONS: Intraarterial iodinated radiographic contrast material may increase cortical intracerebral hemorrhage, similar to heparin. " 05/01/2010 - "Similar trends for increased cortical intracerebral hemorrhage were seen in the contrast-only (P=0.18) and heparin-only (P=0.18) groups. " 05/01/2010 - "Both pooled contrast groups (85.7%) and pooled heparin groups (88.9%) had higher rates of cortical intracerebral hemorrhage compared with the control group (P<0.05). " Order ALL the reference details at left...
2.	Tissue Plasminogen Activator (Alteplase)FDA Link 08/01/2003 - "One of the most important predictors of clinical success is time to treatment, with early treatment of <3 hours for intravenous tissue plasminogen activator and <6 hours for intra-arterial thrombolysis demonstrating significant improvement in terms of 90-day clinical outcome and reduced cerebral hemorrhage. " 06/01/2006 - "BACKGROUND AND PURPOSE: A recent study showed a dramatic increase in cerebral hemorrhage comprising atypical locations with low-frequency ultrasound-mediated recombinant tissue plasminogen activator-thrombolysis in humans. " 09/01/2010 - "Tissue plasminogen activator (t-PA) has a short therapeutic time window for administration (3 h) and carries a risk of promoting intracerebral hemorrhage. " 08/01/2010 - "CONCLUSIONS: There is no significant difference in 90-day mortality, 30-day functional outcome, or rate of symptomatic intracerebral hemorrhage between nonagenarians and octogenarians treated with intravenous tissue plasminogen activator when comparing populations of similar baseline risk." 08/01/2010 - "The main outcome measures included favorable outcome of the patients treated with intravenous tissue plasminogen activator (tPA) at 3 months and symptomatic intracerebral hemorrhage by comparison between walk-in patients and the patients who were referred by the TSN. " Order ALL the reference details at left...
3.	Glucose (Dextrose)FDA LinkGeneric 07/01/1989 - "Intravenous administration of foridone (1 microgram/kg/min) to cats one day after intracerebral hemorrhage produced a significant improvement of blood supply to the brain, glucose utilization by the brain, a moderate increase of oxygen consumption." 05/01/2009 - "Transient focal increase in perihematomal glucose metabolism after acute human intracerebral hemorrhage." 11/01/2005 - "Lower Canadian Neurological Scale score and higher glucose level were predictive of mortality The symptomatic intracerebral hemorrhage (ICH) rate (phase 2 only) was 4.3%. " 03/01/2005 - "CONCLUSION: Protective reaction of the blood-brain barrier can be initiated to ensure glucose supply to the neurons against the injury by cerebral hemorrhage." 11/01/1990 - "A high fasting glucose level was associated with an increased mortality, but this was observed only among patients with intracerebral hemorrhage. " Order ALL the reference details at left...
4.	Interleukin-6 (Interleukin 6)IBA 08/01/2008 - "CONCLUSION: On the basis of medication, cranial needling can promote rapid decrease of serum IL-6 content and improve nervous function in the patient of acute cerebral hemorrhage." 08/01/2008 - "[Effect of cranial needling combined with medicine on IL-6 in the patient of acute cerebral hemorrhage]" 01/01/2008 - "Serum IL-6 and CRP level increases in the first days after intracerebral hemorrhage. " 08/01/2006 - "CONCLUSIONS: IL6 genotype may be useful in assessing the genetic risk for atherothrombotic cerebral infarction and intracerebral hemorrhage, and genotypes for UCP3, TNF, and PKD1-like may be similarly beneficial in assessment of the risk for subarachnoid hemorrhage. " 01/01/1999 - "Further studies will be necessary to clarify the role of the interleukin-6/interleukin-6 receptor pathway in the development of intracerebral hemorrhage frequently occuring in premature infants." Order ALL the reference details at left...
5.	Dexamethasone (Maxidex)FDA LinkGeneric 10/01/2009 - "These results indicate that a 1-mg/kg dose of dexamethasone is beneficial for treatment of intracerebral hemorrhage, particularly if administered early after the hemorrhagic insult." 05/14/1987 - "To evaluate the efficacy of dexamethasone for treatment of primary supratentorial intracerebral hemorrhage, we studied 93 patients 40 to 80 years old, using a double-blind randomized block design. " 02/14/2007 - "This study investigated whether dexamethasone (DEX) treatment could regulate the expression of aquaporin-4 (AQP4) in rats with intracerebral hemorrhage (ICH). " 02/14/2007 - "Dexamethasone treatment modulates aquaporin-4 expression after intracerebral hemorrhage in rats." 01/28/1988 - "Dexamethasone in primary supratentorial intracerebral hemorrhage." Order ALL the reference details at left...
6.	OxygenIBA 09/15/2009 - "Histopathological changes of rat brain after direct injection of Hb-vesicles (artificial oxygen carriers) and neurological impact in an intracerebral hemorrhage model." 05/01/2008 - "[Effect of head elevation on intracranial pressure, cerebral perfusion pressure, and regional cerebral oxygen saturation in patients with cerebral hemorrhage]" 01/01/2008 - "Hyperbaric oxygen for experimental intracerebral hemorrhage." 11/01/2007 - "We therefore interpret the reduced perfusion as a secondary phenomenon, ie, reduced oxygen demand of tissue damaged by pressure and clot components, not as the cause of any tissue damage associated with acute intracerebral hemorrhage." 01/01/2005 - "Brain tissue oxygen monitoring in intracerebral hemorrhage." Order ALL the reference details at left...
7.	FibrinIBA 04/01/2002 - "Postischemic platelet and fibrin deposition were decreased and perfusion increased without increasing intracerebral hemorrhage. " 01/01/1986 - "Localized intravascular coagulation (prethrombi, fibrin thrombi, aggregation and agglutination of red blood cells) in the microcirculatory bed of the brain in hemorrhagic stroke is secondary to cerebral hemorrhage. " 09/29/2000 - "Using this model, we tested the hypothesis that intra-arterial administration of TNK-tPA, a fibrin specific second generation thrombolytic agent, is effective in reducing ischemic volume without increasing intra-cerebral hemorrhage. " 04/01/2005 - "Efficacy of fibrin-specific tissue plasminogen activators has been shown to be generally equivalent, with similar mortality rates compared with nonspecific agents; however, fibrin-specific agents may be associated with an increased incidence of intracerebral hemorrhage and with increased costs. " 03/01/2001 - "Tenecteplase (TNK), a genetically modified form of wild-type tPA, exhibits a longer biological half-life and greater fibrin specificity, features that could lead to fewer cerebral hemorrhages than wild-type tPA in stroke patients. " Order ALL the reference details at left...
8.	10-N-nonylacridinium orange (NAO)IBA 02/28/2002 - "[Effects of nao-yi-an granule on bcl-2 expression in the rat brain after experimental cerebral hemorrhage]" 01/01/1999 - "In order to investigate the efficacy mechanism of Nao Yi-an(NYA) granule on acute cerebral hemorrhage(ACH), 38 cases of ACH were treated with NYA granule(NYA group) or with Western Medicine (WM group). " 02/28/2002 - "OBJECTIVE: To investigate the protective effects and mechanisms of the traditional Chinese medicine complex, nao-yi-an granule (NYA) on experimental intracerebral hemorrhage (ICH) in rats. " 12/28/2000 - "OBJECTIVE: To explore the neuronal protective effects of a traditional Chinese medicine complex Nao-Yi-An granule(NYA) on experimental intracerebral hemorrhage(ICH) in rats. " 01/01/1997 - "The potential inhibitory effect on NDP induction by Nao Yi An (NYA), a complex derived from materials of animal and plant origin used in the treatment of intracerebral hemorrhage in traditional Chinese medicine, was also investigated. " Order ALL the reference details at left...
9.	Thrombin FDA Link 08/21/2008 - "The current study examined 3CB2, a marker of radial glia, expression after intracerebral hemorrhage (ICH) and intracerebral thrombin injection. " 03/01/2009 - "Thrombin and brain recovery after intracerebral hemorrhage." 08/21/2008 - "3CB2, a marker of radial glia, expression after experimental intracerebral hemorrhage: role of thrombin." 07/01/2008 - "Effects of thrombin on neurogenesis after intracerebral hemorrhage." 01/01/2008 - "Increase in brain thrombin activity after experimental intracerebral hemorrhage." Order ALL the reference details at left...
10.	Amyloid (Amyloid Fibrils)IBA 04/01/2008 - "BACKGROUND: A majority of mutations within the beta-amyloid region of the amyloid precursor protein (APP) gene cause inherited forms of intracerebral hemorrhage. " 01/12/2005 - "[Amyloid angiopathy associated with cerebral hemorrhage]" 06/01/2004 - "Lesions in the frontal subcortical WM of BD brains, brains from non-neurological patients, and brains with cerebral hemorrhage or large cortical infarcts were also examined immunohistochemically using molecular markers for axonal flow damage: amyloid precursor protein (APP); and for demyelinating axonopathy: encephalitogenic peptide (EP). " 03/01/2004 - "Lobar cerebral hemorrhage from amyloid angiopathy: clinical, neuroimaging, pathologic and outcome correlations." 01/01/2004 - "It forms self-aggregates with massive amyloid deposits in the brain arteries of young adults, leading to lethal cerebral hemorrhage. " Order ALL the reference details at left...

Therapies and Procedures

1.	Thrombolytic Therapy 12/01/1998 - "In clinical trials, patients treated with thrombolytic therapy have shown a 6% rate of intracerebral hemorrhage, which was balanced against a 30% improvement in functional outcome over controls. " 04/22/1998 - "CONCLUSION: Physicians in this study did not uniformly achieve a level of sensitivity for identification of intracerebral hemorrhage sufficient to permit safe selection of candidates for thrombolytic therapy." 07/01/2009 - "Fibrinolytic therapy appears to be a reasonable less invasive alternative treatment modality for intracerebral hemorrhage in the anticoagulated patient." 03/01/2009 - "The risk of intracerebral hemorrhage after thrombolytic therapy for patients without evidence of arterial occlusion is similar to the risk carried in an unselected patient population. " 10/01/2008 - "After acute thrombolytic therapy, presence of silent cerebrovascular disease increases the risk of intracerebral hemorrhage, but the increased risk does not negate the overall benefit of this therapy. " Order ALL the reference details at left...
2.	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/01/1999 - "AIM: To explore the protective effect and its mechanism of the traditional Chinese medicine complex, naoyi-an granule(NYAG), on intracerebral hemorrhage(ICH) in rats. " 02/28/2002 - "OBJECTIVE: To investigate the protective effects and mechanisms of the traditional Chinese medicine complex, nao-yi-an granule (NYA) on experimental intracerebral hemorrhage (ICH) in rats. " 12/28/2000 - "OBJECTIVE: To explore the neuronal protective effects of a traditional Chinese medicine complex Nao-Yi-An granule(NYA) on experimental intracerebral hemorrhage(ICH) in rats. " 01/01/1997 - "The potential inhibitory effect on NDP induction by Nao Yi An (NYA), a complex derived from materials of animal and plant origin used in the treatment of intracerebral hemorrhage in traditional Chinese medicine, was also investigated. " 01/01/1997 - "Induction of NADPH-diaphorase activity in the forebrain in a model of intracerebral hemorrhage and its inhibition by the traditional Chinese medicine complex Nao Yi An." Order ALL the reference details at left...
3.	Renal Dialysis (Hemodialysis) 01/01/2009 - "METHODS: The current study was conducted in 17 hemodialysis patients who developed a cerebral hemorrhage. " 01/01/2007 - "This study found a high incidence of MBs in patients on maintenance hemodialysis, a correlation between MBs and intracerebral hemorrhage, but no correlation between the duration of hemodialysis and the appearance of MBs. " 08/01/1999 - "This study confirmed a poor prognosis for hemodialysis patients with cerebral hemorrhage. " 01/01/2010 - "Factors affecting outcome of intracerebral hemorrhage in patients undergoing chronic hemodialysis." 02/01/2009 - "However, she died of cerebral hemorrhage 9 months after hemodialysis. " Order ALL the reference details at left...
4.	Craniotomy 12/01/1996 - "OBJECTIVE: The purpose of this study was to analyze the available clinical data on postoperative intracerebral hemorrhages that occur in locations remote from the sites of craniotomy. " 05/01/2009 - "Minimal craniotomy and matrix hemostatic sealant for the treatment of spontaneous supratentorial intracerebral hemorrhage." 04/01/2008 - "Is craniotomy for intracerebral hemorrhage treated properly in the latest AHA guideline?" 11/28/2006 - "[Indication of craniotomy in patients with spontaneous intracerebral hemorrhage]" 10/01/2005 - "A second life-threatening left cerebral hemorrhage occurred three weeks later and was decompressed with a craniotomy. " Order ALL the reference details at left...
5.	Artificial Respiration (Mechanical Ventilation) 01/01/2006 - "BACKGROUND: Up to 30% of patients with supratentorial intracerebral hemorrhage (ICH) require mechanical ventilation during the course of treatment. " 06/01/2004 - "Outcome of patients who underwent mechanical ventilation following intracerebral hemorrhage: is the glass really half full?" 11/01/2003 - "CONCLUSIONS: Probability of survival at 3 yrs after mechanical ventilation for an intracerebral hemorrhage was >50%. " 11/01/2003 - "OBJECTIVE: To evaluate long-term survival and functional outcome in intensive care unit survivors after mechanical ventilation for intracerebral hemorrhage. " 11/01/2003 - "Long-term outcome in intensive care unit survivors after mechanical ventilation for intracerebral hemorrhage." Order ALL the reference details at left...

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