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Tissue Plasminogen Activator (Alteplase)

A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
Also Known As:
Alteplase; Activase; T-Plasminogen Activator; Actilyse; Lysatec rt-PA; TTPA; Tisokinase; Tissue Activator D-44; Lysatec rt PA; Lysatec rtPA; Plasminogen Activator, Tissue; Plasminogen Activator, Tissue Type; T Plasminogen Activator; Tissue Activator D 44; Tissue Type Plasminogen Activator; Plasminogen Activator, Tissue-Type; Tissue-Type Plasminogen Activator
Networked: 10595 relevant articles (943 outcomes, 1863 trials/studies)

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Drug Context: Research Results

Experts

1. Hill, Michael D: 84 articles (06/2022 - 01/2002)
2. Demchuk, Andrew M: 78 articles (04/2022 - 01/2002)
3. Grotta, James C: 77 articles (01/2022 - 04/2002)
4. Schwamm, Lee H: 76 articles (04/2022 - 11/2004)
5. Alexandrov, Andrei V: 72 articles (06/2022 - 01/2002)
6. Smith, Eric E: 70 articles (06/2022 - 10/2004)
7. Saver, Jeffrey L: 69 articles (03/2022 - 06/2003)
8. Davis, Stephen M: 62 articles (01/2022 - 04/2003)
9. Donnan, Geoffrey A: 61 articles (01/2022 - 01/2005)
10. Kimura, Kazumi: 57 articles (03/2022 - 01/2004)

Related Diseases

1. Ischemic Stroke
2. Stroke (Strokes)
3. Hemorrhage
4. Thrombosis (Thrombus)
5. Myocardial Infarction

Related Drugs and Biologics

1. Tissue Plasminogen Activator (Alteplase)
2. Tenecteplase
3. Urokinase-Type Plasminogen Activator (Urokinase)
4. Streptokinase
5. Heparin (Liquaemin)
6. Fibrinolytic Agents (Antithrombotic Agents)
7. Deoxyribonucleases (DNase)
8. Plasminogen Activators (Plasminogen Activator)
9. Plasminogen Activator Inhibitor 1
10. Fibrinogen (Factor I)

Related Therapies and Procedures

1. Therapeutics
2. Thrombolytic Therapy
3. Thrombectomy
4. Catheters
5. Vitrectomy