Should we exclude acute stroke patients with previous intracerebral hemorrhage from receiving intravenous thrombolysis?
Abstract | BACKGROUND: AIM: METHODS: RESULTS: Among 1495 patients who were treated with intravenous recombinant tissue plasminogen activator, 73 (4.9%) had previous intracerebral hemorrhage; 9 on history only, 61 on magnetic resonance imaging only and 3 on both. Of those 1495 patients, 71 (4.7%) experienced symptomatic hemorrhagic transformation; 6.8% in patients with previous intracerebral hemorrhage and 4.6% in those without previous intracerebral hemorrhage. Multivariable logistic regression analysis showed that previous intracerebral hemorrhage did not significantly increase the risk of symptomatic hemorrhagic transformation (odds ratio 1.08, 95% confidence interval 0.39-2.96) mortality, and most of functional outcome measures CONCLUSIONS:
|
Authors | Sang-Hwa Lee, Beom Joon Kim, Moon-Ku Han, Tai Hwan Park, Kyung Bok Lee, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Jae Kwan Cha, Dae-Hyun Kim, Hyun-Wook Nah, Jun Lee, Soo Joo Lee, Youngchai Ko, Jae Guk Kim, Jong-Moo Park, Kyusik Kang, Yong-Jin Cho, Keun-Sik Hong, Jay Chol Choi, Joon-Tae Kim, Kangho Choi, Dong-Eog Kim, Wi-Sun Ryu, Wook-Joo Kim, Dong-Ick Shin, Minju Yeo, Juneyoung Lee, Ji Sung Lee, Philip B Gorelick, Hee-Joon Bae |
Journal | International journal of stroke : official journal of the International Stroke Society
(Int J Stroke)
Vol. 11
Issue 7
Pg. 783-90
(10 2016)
ISSN: 1747-4949 [Electronic] United States |
PMID | 27312681
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
|
Copyright | © 2016 World Stroke Organization. |
Chemical References |
- Fibrinolytic Agents
- Recombinant Proteins
- Tissue Plasminogen Activator
|
Topics |
- Administration, Intravenous
- Aged
- Brain
(diagnostic imaging, drug effects)
- Brain Ischemia
(complications, diagnostic imaging, drug therapy)
- Cerebral Hemorrhage
(complications, diagnostic imaging, drug therapy)
- Female
- Fibrinolytic Agents
(adverse effects, therapeutic use)
- Humans
- Magnetic Resonance Imaging
- Male
- Prospective Studies
- Recombinant Proteins
(therapeutic use)
- Registries
- Retrospective Studies
- Risk
- Stroke
(complications, diagnostic imaging, drug therapy)
- Thrombolytic Therapy
(adverse effects)
- Tissue Plasminogen Activator
(adverse effects, therapeutic use)
- Treatment Outcome
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|