Antihypertensive Agents (Antihypertensives)

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

Also Known As:

Antihypertensives; Antihypertensive Drugs; Anti-Hypertensive Agents; Anti-Hypertensive Drugs; Anti-Hypertensives; Agent, Anti-Hypertensive; Agent, Antihypertensive; Agents, Anti-Hypertensive; Agents, Antihypertensive; Anti Hypertensive; Anti Hypertensive Agent; Anti Hypertensive Agents; Anti Hypertensive Drug; Anti Hypertensive Drugs; Anti Hypertensives; Drug, Anti-Hypertensive; Drug, Antihypertensive; Drugs, Anti-Hypertensive; Drugs, Antihypertensive; Anti-Hypertensive; Anti-Hypertensive Agent; Anti-Hypertensive Drug; Antihypertensive; Antihypertensive Agent; Antihypertensive Drug

Networked: 24326 relevant articles (1744 outcomes, 4505 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Therapeutic Uses: 47080
    - Cardiovascular Agents: 817
      - Antihypertensive Agents: 24326

Experts

1.	Muntner, Paul: 120 articles (09/2022 - 04/2002)
2.	Oparil, Suzanne: 110 articles (12/2022 - 03/2002)
3.	Davis, Barry R: 97 articles (01/2022 - 09/2002)
4.	Mancia, Giuseppe: 94 articles (04/2022 - 03/2002)
5.	He, Jiang: 86 articles (04/2022 - 04/2002)
6.	Poulter, Neil R: 82 articles (01/2022 - 06/2004)
7.	Kario, Kazuomi: 80 articles (01/2022 - 01/2002)
8.	Kjeldsen, Sverre E: 76 articles (01/2021 - 03/2002)
9.	Devereux, Richard B: 76 articles (10/2019 - 02/2002)
10.	Bakris, George L: 72 articles (01/2022 - 01/2002)

Related Diseases

1.	Hypertension (High Blood Pressure) 08/01/2023 - "Recently, a few studies demonstrated that the gut microbiota is highly involved in the modulation of the efficacy of antihypertensive drugs, suggesting a novel mechanism by which gut microbiota plays a role in treatment-resistant hypertension. " 01/21/2021 - "This trial will help to identify the most effective and cost-effective treatment strategies for uncomplicated arterial hypertension among people of African descent living in rural sub-Saharan Africa and inform future clinical guidelines on antihypertensive management in the region. " 10/01/2003 - "We conclude that the combination of event reduction from large-scale clinical trials, adequate 24 h BP reduction, and improved tolerability compared to most other classes of anti-hypertensive agents, make the ARBs a suitable initial treatment for patients with hypertension." 01/01/2022 - "Most participants (58%) with uncontrolled hypertension had a DGI reducing the efficacy of one or more antihypertensive agents. " 01/01/2020 - "Anti-hypertensive drugs are the common and effective cure for lowering blood pressure in patients with hypertension. "
2.	Essential Hypertension 01/01/2013 - "Meta-analysis showed that QJDHW combined with antihypertensive drugs was more effective in lowering blood pressure and improving TCM syndrome for the treatment of essential hypertension than antihypertensive drugs used alone. " 04/01/2015 - "SXC used alone or combined with antihypertensive drugs appear to be an effective treatment for lowering elevated blood pressure and improving symptoms in patients with primary hypertension. " 01/01/2013 - "Our review suggests that QJDHW combined with antihypertensive drugs might be an effective treatment for lowering blood pressure and improving symptoms in patients with essential hypertension. " 01/01/2012 - "LWDHW combined with antihypertensive drugs appears to be effective in improving blood pressure and symptoms in patients with essential hypertension. " 09/18/2020 - "Although the efficacy of antihypertensive drugs has been well established for primary hypertension, their effectiveness is always limited by side effects and poor compliance. "
3.	Stroke (Strokes) 08/01/2015 - "Among the antihypertensive classes, CCBs were most effective in reducing the long-term incidence of stroke, whereas β-blockers were associated with significantly increased risk." 06/01/2009 - "Although meta-analyses suggest that BP reduction, per se, is the most important determinant for stroke risk reduction, the question is if specific classes of antihypertensive drugs offer special protection against stroke is still controversial. " 01/01/2003 - "However, it is not known which antihypertensive agents are most effective in preventing stroke. " 03/01/2006 - "ARBs have been proven to be effective in the prevention of stroke via mechanisms that are both dependent on and independent of the antihypertensive abilities of the drugs." 08/01/1995 - "Specific alterations of the coronary circulation may account for the relative failure of antihypertensive drugs, despite their proven efficacy in other systems (e.g., stroke prevention). "
4.	Cardiovascular Diseases (Cardiovascular Disease) 01/01/2021 - "Antihypertensive drug treatment is cost-effective for adults at high risk of developing cardiovascular disease (CVD). " 01/01/2019 - "No significant benefits for RAS inhibitors were found compared to other classes of antihypertensives for all-cause death (relative risk (RR) 0.95, 95% confidence interval (CI) 0.85-1.05, p = 0.29), cardiovascular death (RR 0.84, 95% CI 0.68-1.04, p = 0.11), incidence of cardiovascular disease (RR 0.93, 95% CI 0.84-1.03, p = 0.16), and incidence of renal dysfunction (RR 0.91, 95% CI 0.77-1.06, p = 0.22). " 07/15/2004 - "New anti-hypertensive drugs, although more expensive than conventional treatments, have significant benefits in the management of cardiovascular disease. " 12/01/1990 - "Early identification of borderline hypertensives at risk of cardiovascular disease and detailed information on the efficacy of different antihypertensive regimens may in part justify the high costs of the monitors. " 01/30/2023 - "Although standardized treatment protocols simplify the selection of antihypertensive drugs and ensure therapeutic efficacy, the pathophysiological state of some patients remains, which may also lead to the development of other cardiovascular diseases. "
5.	Heart Failure 02/01/1989 - "This can partially explain why antihypertensive treatment is effective in diminishing the incidence of congestive heart failure, which is the final consequence of LVH, but is not very effective in preventing coronary complications. " 01/01/2019 - "In the rtPA group with antihypertensive (anti-HTN) medication, only NIHSS score (OR = 1.094, 95% CI, 1.094-1.000, P = 0.005) was associated with improved functional outcome while patients with congestive heart failure (OR = 0.385, 95% CI, 0.385-0.159, P = 0.035) and patients with a history of previous TIA (OR = 0.302, 95% CI, 0.302-0.113, P = 0.017) were more likely to be associated with poor functional outcomes. " 03/01/1991 - "Following antihypertensive management, symptoms of congestive heart failure improved. " 07/01/2023 - "The effects of blood pressure and antihypertensive drugs on heart failure: A Mendelian randomization study." 01/01/2023 - "This study aimed to estimate the causal association of BP with heart failure, and explore the effects of BP-lowering through different antihypertensive drug classes on heart failure risk using Mendelian randomization analysis with genetic variants as instrument variables. "

Related Drugs and Biologics

1.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
2.	Diuretics
3.	Antihypertensive Agents (Antihypertensives)
4.	Amlodipine (Norvasc)
5.	Lipids
6.	Calcium Channel Blockers (Blockers, Calcium Channel)
7.	Calcium
8.	Nifedipine (Adalat)
9.	Hydrochlorothiazide (Esidrix)
10.	Losartan (Cozaar)

Related Therapies and Procedures

1.	Therapeutics
2.	Denervation
3.	Drug Therapy (Chemotherapy)
4.	Adrenalectomy
5.	Nephrectomy