Central Nervous System Diseases (CNS Diseases)

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1005 relevant articles (51 outcomes, 72 trials/studies) found for this Disease

Description: Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.

Also Known As:

CNS Diseases; Central Nervous System Disorders; CNS Disease

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3643

Central Nervous System Diseases: 1005

Meningitis: 5878

Movement Disorders: 1584

Spinal Cord Diseases: 1403

Brain Diseases: 1203

Encephalomyelitis: 665

Central Nervous System Infections: 250

Ocular Motility Disorders: 212

Pneumocephalus: 160

High Pressure Neurological Syndrome: 123

Related Diseases

1.	Leukemia
2.	Syndrome
3.	Alzheimer Disease (Alzheimer's Disease)
4.	Neoplasms (Cancer)
5.	Lymphoma (Lymphomas)

Experts

1.	Honnorat, J: 2 articles (05/2008 - 01/2000)
2.	Stüve, Olaf: 2 articles (07/2006 - 12/2005)
3.	Lassmann, Hans: 2 articles (08/2004 - 06/2002)
4.	Emerich, D F: 2 articles (01/2001 - 01/2001)
5.	Thompson, Leslie M: 1 article (10/2008)
6.	Kazantsev, Aleksey G: 1 article (10/2008)
7.	Oana, Shingo: 1 article (08/2008)
8.	Ishii, Chiako: 1 article (08/2008)
9.	Hoshika, Akinori: 1 article (08/2008)
10.	Yamanaka, Gaku: 1 article (08/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Central Nervous System Diseases:

1.	DNA (Deoxyribonucleic Acid)IBA 01/01/1998 - "Additionally, quantitation of HCMV DNA can be a useful marker for monitoring the antiviral efficacy of therapies of HCMV-related CNS disease." 04/01/2003 - "Most cases of neonatal HSV disease are caused by HSV type 2, whereas virtually all cases of HSE are caused by HSV type 1. Diagnostic advances made during the past decade include the application of polymerase chain reaction (PCR) technology to cerebrospinal fluid from patients with suspected HSV CNS disease to evaluate for the presence of HSV DNA. " 06/01/2001 - "Human herpes virus type 7 DNA in the cerebrospinal fluid of children with central nervous system diseases." 03/01/1999 - "In addition, none of the five cases with HHV-6 DNA detected in CSF samples had any other identified cause of their CNS symptoms, and none of the other 11 cases with known causes for their CNS diseases had HHV-6 DNA detected in CSF samples (P = .03, Fisher's exact test). " 12/01/1998 - "Additionally, HCMV DNA was detected in the CSF of two patients with noninflammatory CNS diseases. " Order ALL the reference details at left...
2.	Cytarabine (Cytosar-U)FDA LinkGeneric 05/01/2002 - "In multivariate analysis, non-L2-FAB, higher ara-C dose, absence of CNS disease, non-Ph1+ karyotype, allogeneic BMT, T cell phenotype, and younger age were associated with improved disease-free survival. " 04/15/2007 - "Liposomal cytarabine 50 mg was given intrathecally on days 2 and 15 of hyper-CVAD and day 10 of high-dose MTX and cytarabine courses until completion of either 3, 6, or 10 IT treatments, depending on risk for CNS disease. " 01/01/1985 - "For established CNS disease, IT-Ara-C for three days followed by MTX on the fourth day is effective. " 10/01/1990 - "Cytarabine is effective in the treatment of leukemias and CNS disease when given SQ, IM, IV, or intrathecally. " 03/01/2006 - "The prevention and treatment of CNS disease is an important aspect of lymphoma management, and new medications, such as a sustained-release formulation of intrathecal cytarabine, will have an increasingly relevant role." Order ALL the reference details at left...
3.	Ganciclovir (Cytovene)FDA LinkGeneric 06/01/1996 - "Ganciclovir-resistant CMV, containing a UL97 mutation, was cultured from blood and urine before clinical indication of CMV central nervous system (CNS) disease, suggesting that the development of ganciclovir resistance preceded the dissemination of CMV to the CNS. " 11/01/1995 - "The CSF of all seven patients who had not received ganciclovir prior to the development of CNS disease and four patients who had been receiving the drug for 3 to 8 months contained wild-type UL97 sequences. " 11/01/1995 - "These findings indicate that CNS disease in AIDS patients receiving prolonged ganciclovir therapy can be caused by ganciclovir-resistant HCMV strains. " 06/01/2004 - "Although ganciclovir is unlikely to be effective against HHV-7-related CNS disease, foscarnet may be useful but prospective trials are needed." 01/01/1995 - "Ganciclovir treatment of 3 patients with HCMV-related CNS disease was associated with a decline in HCMV DNA detectable within CSF. " Order ALL the reference details at left...
4.	Foscarnet FDA LinkGeneric 06/01/2004 - "Although ganciclovir is unlikely to be effective against HHV-7-related CNS disease, foscarnet may be useful but prospective trials are needed." 03/01/1999 - "Four cases' conditions were improved or they were cured after treatment with either ganciclovir or foscarnet, and one case died of CNS disease despite foscarnet treatment." 11/01/1996 - "ACTG 305, a 6-month, high dose, aggressive combination foscarnet/ganciclovir therapy has been developed to answer many of the nagging treatment issues surrounding CMV CNS disease as well as evaluate both quantitative CMV DNA PCR and CMV bDNA as assays for disease severity, progression, and response to therapy." Order ALL the reference details at left...
5.	Methotrexate (Mexate)FDA LinkGeneric 04/23/2009 - "Intrathecal methotrexate has no role in preventing CNS disease for patients treated with combined immunochemotherapy (R-CHOP-14)--with the possible exception of patients with testicular involvement." 04/01/2007 - "All patients with CNS disease had additional high-dose methotrexate (8 g/m2) plus extra intrathecal therapy. " 06/01/2001 - "High doses of intravenous methotrexate and 12 triple intrathecal doses were given as prophylaxis against central nervous system (CNS) disease. " 11/01/1988 - "Methotrexate is an active agent in testicular germ cell tumours and should be of particular value in treating CNS disease where intrathecal treatment may be required." 03/01/1987 - "Once CNS disease developed the sequelae were frequent and severe, due to the elevated methotrexate levels in the cerebrospinal fluid. " Order ALL the reference details at left...
6.	tebufenozide (Mimic)IBA 10/01/2004 - "The application of molecular diagnostic methods for diagnosis of specific infectious entities is reviewed in detail, including viruses for which PCR is of proven efficacy and is widely available, viruses for which PCR is less widely available or for which PCR has unproven sensitivity and specificity, and nonviral entities which can mimic viral CNS disease." 07/01/1992 - "Because brain biopsies are not routinely included in the diagnostic workup of non-neoplastic CNS diseases, a number of unconfirmed nonvasculitic conditions may mimic PACNS. " 01/01/2001 - "The discovery of cellular receptors for MV entry has facilitated the development of transgenic mice that are susceptible to MV infection, and that mimic certain aspects of the central nervous system diseases and immunosuppression that can occur in infected humans. " 08/01/1986 - "Many clinicians may be unaware, therefore, that ECT has been used safely to treat patients with combined major depression and central nervous system disorders; patients with organic mental syndromes, particularly delirium; and patients who have psychiatric disorders that mimic or are distorted by brain disease. " 11/01/2004 - "However, acute microinjections of IL-1 do not mimic the chronic IL-1 expression, which is a feature of many CNS diseases. " Order ALL the reference details at left...
7.	AntibodiesIBA 01/01/2003 - "Subclinical central nervous system (CNS) disease in NLE is likely to be a transient phenomenon that resolves as maternal antibodies are cleared from the infant's circulation. " 05/01/2009 - "CONCLUSIONS AND CLINICAL IMPORTANCE: Based on this study, these bacteria are unlikely causes of neurologic disease in dogs and the presence of serum antibodies alone does not document or establish a definitive diagnosis of CNS disease caused by these organisms. " 01/01/2003 - "This evidence consists of 1) seven independent studies showing a strong relationship between anti-P antibodies and CNS disease; 2) longitudinal studies showing fluctuations of anti-P antibodies with episodes of psychosis; 3) correlation of anti-P antibodies with general disease activity; and 4) acid eluates form lupus renal tissue were found to contain anti-P antibodies enriched 30-fold with respect to their specific activity in serum heralding a direct role of anti-P antibodies in disease expression. " 08/01/1993 - "This study examines the spectrum of psychiatric and cognitive dysfunction observed in SS patients with focal, as well as nonfocal, central nervous system (CNS) disease and relates these observations to the presence of serum and cerebrospinal fluid (CSF) anti-ribosomal and anti-neuronal antibodies. " 05/01/2009 - "RESULTS: Dogs with inflammatory CNS diseases showed no serum antibodies against any of the agents. " Order ALL the reference details at left...
8.	Immunoglobulin M (IgM)IBA 01/01/1983 - "Specific IgM to measles virus was found in 41% of MS patients, in 15% of their nearest relatives, and in 19.7% of patients with other CNS diseases, but not in healthy subjects. " 09/01/1991 - "The study presented here demonstrates that CSF oligoclonal IgA and IgM may be helpful in monitoring CNS disease activity in neuro-Behçet's and could be useful in understanding the pathogenesis of this disease." 12/01/2004 - "Persistence of West Nile Virus (WNV) IgM antibodies in cerebrospinal fluid from patients with CNS disease." 05/01/1979 - "Cold-reactive antibodies of the IgM class were equally prevalent in patients with or without CNS disease and appeared to be more directly correlated with extra-CNS systemic illness. " 12/01/2004 - "As a result of year-round testing for WNV infections during 2002-2003, we detected WNV IgM-specific antibodies in cerebrospinal fluid (CSF) specimens from three patients persisting for 110, 141, and 199 days post acute phase infection in patients with central nervous system (CNS) disease. " Order ALL the reference details at left...
9.	Proteins (Proteins, Gene)IBA 03/01/2008 - "Electron paramagnetic resonance spectroscopy (EPR) has the potential to give much detail on the structure of the paramagnetic transition ion coordination sites, principally of Cu2+, in a number of proteins associated with central nervous system diseases. " 03/01/2007 - "The results of investigations of the neurochemical mechanisms of LVT action suggest that proteins involved in the vesicular exocytosis, in particular SV2, can be promising targets in the search for new effective agents for the treatment of CNS diseases." 10/30/2005 - "2-DE combined with mass spectrometry can help to identify pathological relevant proteins in the enteric nervous system, and so deliver a valuable tool for the early diagnosis of also central nervous system diseases by using biopsies from the gut." 09/01/2005 - "In central nervous system diseases, abnormal aggregation of one protein is often associated with aggregation of other proteins. " 07/01/2005 - "In this article, I will provide an overview of the current, and rapidly expanding, knowledge of how this important family of proteins might be involved in various major CNS diseases, the proposed role of NCS proteins in pathophysiological signaling and the development of pharmacological tools and novel research strategies." Order ALL the reference details at left...
10.	Glutamic Acid (Glutamate)FDA Link 10/01/2005 - "Modulation of the metabotropic glutamate subtype 5 (mGlu5) receptor may be useful in the treatment of a variety of central nervous system disorders. " 08/30/2008 - "l-Glutamate-induced MMP-2 activity may contribute to neuropathology in various CNS diseases and may generate misleading data in pathogen studies where Middlebrook 7H9 is the culture medium." 09/01/2005 - "Excitotoxicity is a cell death caused by excessive exposure to glutamate (Glu), contributing to neuronal degeneration in many acute and chronic CNS diseases. " 11/01/1998 - "[Glutamate and peroxidation in the pathogenesis of CNS diseases]" 03/03/1998 - "Effects of feline immunodeficiency virus on astrocyte glutamate uptake: implications for lentivirus-induced central nervous system diseases." Order ALL the reference details at left...

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 04/01/2009 - "Mesenchymal stem cell (MSC) transplantation is a promising approach in the therapy of ischemic heart or CNS diseases; however, the poor viability of MSCs after transplantation critically limits the efficacy of this new strategy. " 01/01/2009 - "METHODS: Between November 2001 and January 2008, 1,255 participants with central nervous system diseases were enrolled in this clinical study for fetal OECs transplantation. " 04/01/2009 - "This article briefly reviews some of the relevant issues regarding the transplantation of cells for treatment of PD and hypothesizes how interventional MRI may be useful to optimize the surgical delivery of cells for PD and other central nervous system disorders." 01/01/2009 - "OBJECTIVE: To analyze the therapeutic effect of olfactory ensheathing cells (OECs) transplantation for central nervous system diseases. " 01/01/2009 - "[Olfactory ensheathing cells transplantation for central nervous system diseases in 1,255 patients]" Order ALL the reference details at left...
2.	Drug Therapy (Chemotherapy) 03/01/1997 - "Recommendations of the "CNS Diseases" Study Group of the Paul Ehrlich Society of Chemotherapy e.V. and the German Society of Pediatric Infectiology]" 10/01/2009 - "In younger patients, more aggressive immuno-chemotherapy regimens containing CNS-penetrating agents may reduce the incidence of CNS disease. " 08/10/2007 - "[Central nervous system diseases induced by drug therapies]" 03/15/2007 - "Finally, new developments in systemic approaches to the treatment of CNS disease, including cytotoxic chemotherapy and targeted therapy, are explored." 12/01/2005 - "Following the institution of intrathecal chemotherapy, only 8% (3 of 39) of patients have developed CNS disease. " Order ALL the reference details at left...
3.	Transplants (Transplant) 08/01/1984 - "Survival after relapse ranged from 11 to 476 weeks (median 92); seven patients are alive; four in continued remission, two with recurrent but controlled CNS disease, and one in remission following bone marrow transplant after subsequent marrow relapse. " 06/01/2005 - "Thus, the results of this study support the possible use of autologous-cell graft systems to treat central nervous system diseases in geriatric patients." 08/25/2000 - "Recent advances in the isolation and characterization of neural precursor cells suggest that they have properties that would make them useful transplants for the treatment of central nervous system disorders. " 08/01/2000 - "Thus, the human OEC represents an important new cell for the development of transplant therapy of CNS diseases." 04/01/1996 - "CNS disease was seen in seven patients at 217-1209 days (median 340), none of whom had CNS disease pre-transplant. " Order ALL the reference details at left...
4.	Tissue Therapy (Cell Therapy) 12/06/2006 - "Thus, our findings suggest the potential use of PMSCs for a cell therapy in CNS diseases." 06/01/2001 - "These results evidence the high plasticity of newborn PSA-NCAM+ neural precursors and suggest that they are promising tools for cell therapy of CNS diseases, including myelin disorders." 04/01/2001 - "[Neural stem cells derived from adult human brain: implications for a cell therapy for CNS diseases]" 01/01/2001 - "Immunoisolation cell therapy for CNS diseases." 01/01/2001 - "Update on immunoisolation cell therapy for CNS diseases." Order ALL the reference details at left...
5.	Traditional Medicine (Folk Remedies) 08/01/2005 - "Galphimia glauca has been used in Mexican traditional medicine as a remedy for the treatment of nervous excitement and other central nervous system disorders. " 11/20/2008 - "AIM OF THE STUDY: Tagetes lucida (Asteraceae), has been referred in Mexican traditional medicine for the treatment of different central nervous system (CNS) diseases, mainly depression. " 08/11/2006 - "Salvia elegans Vahl (Lamiaceae), popularly known as "mirto", is a shrub that has been widely used in Mexican traditional medicine for the treatment of different central nervous system (CNS) diseases, principally, anxiety. " Order ALL the reference details at left...

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