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Alterations of T-lymphocyte subsets, soluble IL-2 receptor, and IgE in peripheral blood of children with acute asthma attacks.

AbstractBACKGROUND:
T-cell activation and alteration of cytokines are involved in the pathogenesis of atopic asthma. However, the profile of circulating T-lymphocyte subsets, related cytokines, and plasma IgE during acute asthma attacks is still unclear.
OBJECTIVE:
In an attempt to illustrate the dynamics of these parameters in asthma attacks, we investigated the changes of T-cell subsets, lymphocyte activation, soluble IL-2R, and IgE in peripheral blood in children during and after acute asthma attacks.
METHODS:
This study was carried out in a cohort of Chinese children (n = 59) with acute asthma attacks. Immunoassays were performed when the patients had acute attacks before treatment, and the patients were reexamined in the 4 weeks after the resolution of acute attacks with therapy. Paired t tests were used for the statistical analysis of these patients to compare the data obtained during and after the acute attacks. Twenty healthy, age-matched subjects were used as normal control subjects. Nine children with long-term stable asthma were used as control subjects with stable asthma.
RESULTS:
CD3+, CD4+, CD8+, and IL-2R+ (CD25+) cells; plasma soluble IL-2 receptor; and IgE were significantly higher in patients with acute attacks than in control subjects. (P <.05, P <.05, P <.001, P <.05, P <.0001, and P <.0001, respectively). Immunoelectron microscopy exhibited an increased expression of IL-2R on lymphocytes in acute attacks as compared to control subjects. The abnormalities returned to normal, with the exception of IgE, when clinical remission was achieved after treatment. Correlation analyses revealed a positive relationship between plasma IgE and soluble IL-2R in asthma attacks (r = 0.83, P =.0001). Plasma IgE and soluble IL-2R of those who were in remission positively correlated with their production in acute attacks (r = 0.58, P =.001 and r = 0.71, P =.0001, respectively).
CONCLUSION:
This study suggests that (1) the percentage of CD4+, CD8+, or IL-2R+ lymphocytes in peripheral blood was significantly elevated during acute attacks and returned to normal ranges after complete remission was achieved; (2) plasma soluble IL-2R is a sensitive marker for asthma activity; and (3) atopic asthmatic children seem to have a hereditary predisposition of having higher levels of soluble IL-2R in asthma attacks, coinherited with the trait of IgE.
AuthorsH Z Shi, J J Sun, H L Pan, J Q Lu, J L Zhang, J D Jiang
JournalThe Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 103 Issue 3 Pt 1 Pg. 388-94 (Mar 1999) ISSN: 0091-6749 [Print] UNITED STATES
PMID10069870 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, CD
  • Receptors, Interleukin-2
  • Immunoglobulin E
Topics
  • Acute Disease
  • Antigens, CD (analysis)
  • Asthma (blood, epidemiology, immunology, pathology)
  • Child
  • Child, Preschool
  • China (epidemiology)
  • Cohort Studies
  • Convalescence
  • Female
  • Humans
  • Immunoglobulin E (blood)
  • Immunophenotyping
  • Lymphocyte Activation
  • Lymphocyte Count
  • Male
  • Receptors, Interleukin-2 (blood)
  • Solubility
  • T-Lymphocyte Subsets (immunology)
  • Treatment Outcome

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