Chronic Urticaria

Wheals (urticaria) and/or angioedema presented with daily symptoms lasting for more than 6 weeks. It may be classified into chronic spontaneous and chronic inducible urticaria depending on whether a specific trigger can be linked to the development of vascular reaction.

Also Known As:

Autoimmune Urticaria, Chronic; Autoimmune Urticarias; Chronic Autoimmune Urticarias; Chronic Idiopathic Urticarias; Chronic Spontaneous Urticarias; Chronic Urticaria, Idiopathic; Chronic Urticarias; Idiopathic Chronic Urticarias; Idiopathic Urticaria, Chronic; Spontaneous Urticaria, Chronic; Urticaria, Autoimmune; Urticaria, Chronic; Urticaria, Chronic Autoimmune; Urticaria, Chronic Idiopathic; Urticaria, Chronic Spontaneous; Urticaria, Idiopathic Chronic; Autoimmune Urticaria; Chronic Autoimmune Urticaria; Chronic Idiopathic Urticaria; Chronic Spontaneous Urticaria; Idiopathic Chronic Urticaria

Networked: 2685 relevant articles (385 outcomes, 443 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Urticaria (Hives)
2.	Allergic Rhinitis
3.	Asthma (Bronchial Asthma)
4.	Atopic Dermatitis (Atopic Eczema)
5.	Pruritus (Itching)

Experts

1.	Maurer, Marcus: 89 articles (02/2022 - 06/2008)
2.	Asero, R: 41 articles (01/2022 - 08/2000)
3.	Maurer, M: 38 articles (06/2021 - 04/2004)
4.	Metz, Martin: 32 articles (01/2022 - 07/2009)
5.	Asero, Riccardo: 30 articles (01/2022 - 05/2002)
6.	Park, Hae-Sim: 26 articles (05/2022 - 02/2007)
7.	Staubach, Petra: 24 articles (03/2022 - 07/2009)
8.	Ye, Young-Min: 23 articles (02/2022 - 02/2007)
9.	Tedeschi, A: 21 articles (01/2016 - 05/2001)
10.	Bernstein, Jonathan A: 20 articles (01/2022 - 08/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronic Urticaria:

1.	Omalizumab (Xolair)FDA Link 11/20/2021 - "Omalizumab is the best treatment for patients with chronic spontaneous urticaria (CSU). " 01/01/2021 - "Omalizumab (OMA) is highly effective for refractory chronic spontaneous urticaria (CSU), but its high cost exerts a great economic burden on patients and society. " 07/01/2018 - "Omalizumab is highly effective in controlling chronic spontaneous urticaria (CSU) symptoms; however, patients can experience symptom return on treatment discontinuation. " 04/01/2017 - "Omalizumab 300 mg administered every 4 weeks appears to be the most effective and safe dosage, with a rapid response time, for the treatment of chronic idiopathic urticaria, with few minor adverse effects, and appears to be safe in the offspring of pregnant patients who received the drug. " 02/01/2014 - "Omalizumab is effective in most subsets of chronic urticaria sufferers who do not respond to other treatments but its high cost represents a limitation to its widespread use. "
2.	Histamine Antagonists (Antihistamines)IBA 10/01/2015 - "At standard doses, several antihistamines are effective and safe in complete suppression of chronic spontaneous urticaria. " 12/01/2022 - "The treatment of chronic urticaria (CU) is difficult, currently, antihistamines (AH) are the mainstay of treatment, however, up to 40% of patients do not respond to even high (four-fold) daily doses of AH. " 01/01/2014 - "A significant proportion of patients with chronic urticaria respond inadequately to first line treatment with antihistamines. " 06/01/2022 - "A standard dose of second-generation H1 -antihistamines is recommended as the first-line treatment of chronic spontaneous urticaria (CSU), previous studies have found that approximately 20-50% of CSU children fail to control their symptoms and required step-up treatments. " 01/01/2018 - "Indeed, agents previously used to treat other autoimmune and inflammatory diseases, have demonstrated efficacy in chronic spontaneous urticaria and are therefore potential therapeutic alternatives for antihistamine unresponsive patients."
3.	Cetirizine (Zyrtec)FDA LinkGeneric 08/01/2008 - "Cetirizine as an initial treatment for chronic urticaria appears effective and safe. " 10/01/2007 - "Increasing the dose of cetirizine may lead to better control of chronic idiopathic urticaria: an open study of 21 patients." 01/01/1998 - "A STUDY ON TREATMENT OF CHRONIC IDIOPATHIC URTICARIA WITH CETIRIZINE." 02/01/1992 - "In a separate study in patients with chronic urticaria, cetirizine markedly reduced both the immediate wheal and flare induced by PAF and the delayed reaction at six hours. " 08/01/2008 - "We investigated the suitability of cetirizine HCl (cetirizine) for the initial treatment of chronic urticaria. "
4.	Immunoglobulin E (IgE)IBA 01/01/2017 - "However, OmAb is equally and rapidly effective against autoimmune and non-autoimmune urticaria where IgE involvement is not clear, suggesting the involvement of additional mechanisms of action. " 01/01/2016 - "However, OmAb is equally and rapidly effective against autoimmune and non-autoimmune urticaria, suggesting the possible involvement of additional mechanisms of IgE. " 01/01/2022 - "This study investigated the relationship between platelet and immunoglobulin-E markers and chronic idiopathic urticaria. " 03/01/2021 - "The search terms used were "chronic urticaria" and "total IgE." Studies were screened by titles and abstracts, and 141 were used in the review. " 05/01/2015 - "IgE FcɛR1β polymorphism and risk of developing chronic spontaneous urticaria: A study in an ethnic Kashmiri population."
5.	desloratadine (Aerius)FDA LinkGeneric 09/01/2008 - "CONCLUSION: In an open-label, observational study, desloratadine 5 mg once daily significantly decreased symptoms of chronic idiopathic urticaria and improved subject QoL." 03/01/2009 - "Desloratadine, a non-sedating, second-generation H(1)-receptor antagonist, is an effective and well-tolerated treatment for chronic idiopathic urticaria (CIU). " 01/01/2010 - "The aim of this investigation was to evaluate the safety, tolerability and efficacy of desloratadine 5 mg once daily in four postmarketing surveillance studies in subjects with seasonal AR (SAR) or chronic idiopathic urticaria (CIU) in real-world clinical practice settings. " 03/01/2009 - "Safety and efficacy of desloratadine in chronic idiopathic urticaria in clinical practice: an observational study of 9246 patients." 09/01/2008 - "Impact of Desloratadine on Symptoms and Quality of Life in Subjects with Chronic Idiopathic Urticaria: A Multicenter, Practice-based Study."
6.	levocetirizine FDA LinkGeneric 09/01/2017 - "An open-label prospective clinical study to assess the efficacy of increasing levocetirizine dose up to four times in chronic spontaneous urticaria not controlled with standard dose." 09/01/2017 - "A single-center, double-blind, randomized, active-controlled, parallel group phase IV trial (CTRI/2014/12/005261) was conducted on 120 patients of chronic urticaria of either sex not responding to 5 mg levocetirizine. " 04/01/2006 - "Levocetirizine in patients with chronic idiopathic urticaria: results of a multicenter clinical practice study." 03/01/2006 - "Levocetirizine in the treatment of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study." 01/01/2006 - "Cost effectiveness of levocetirizine in chronic idiopathic urticaria : a pooled analysis of two randomised controlled trials."
7.	Cyclosporine (Ciclosporin)FDA LinkGeneric 10/01/2007 - "Cyclosporin is also effective and can be used in selected cases of autoimmune urticaria, and it is also effective in non-autoimmune cases, although less so." 08/01/2004 - "Despite the disabling nature of chronic urticaria (CU), little is known about the disease's duration or the efficacy of adopting aggressive therapeutic regimens such as cyclosporine A. " 03/01/1997 - "In a limited number of severe chronic idiopathic urticaria (CIU) patients, low-dose cyclosporin A (CsA) treatment was found to be effective. " 09/01/2019 - "This study aimed to systemically review literature relating to factors that could potentially predict a favorable response to cyclosporine A (CsA) treatment for chronic spontaneous urticaria (CSU). " 10/01/2006 - "Cyclosporine in chronic idiopathic urticaria: a double-blind, randomized, placebo-controlled trial."
8.	anti-IgE antibodiesIBA 06/17/2022 - "This comprehensive review aims to present recently acquired knowledge on managing chronic spontaneous urticaria with new anti-IgE antibodies. " 01/01/2021 - "Anti-IgE for the Treatment of Chronic Urticaria." 09/01/2015 - "Anti-IgE for chronic urticaria - are children little adults after all?" 05/01/2015 - "Therefore, serum testing for anti-IgE receptor Ab is required to identify this subgroup of chronic urticaria patients." 05/01/2015 - "Totally, 438 patients with a clinical presentation of chronic urticaria (2011-2013) had anti-IgE receptor Ab tested and 37 of those patients had skin biopsy. "
9.	Histamine (Histamine Dihydrochloride)FDA Link 04/01/2018 - "A Histamine-Free Diet Is Helpful for Treatment of Adult Patients with Chronic Spontaneous Urticaria." 02/01/2000 - "The aim of this study was to evaluate the effects of an oligoantigenic and histamine-free diet on patients affected with chronic idiopathic urticaria (CIU). " 07/01/2023 - "Allergic rhinoconjunctivitis and chronic urticaria are common histamine-driven diseases, exerting detrimental effects on cognitive functions, sleep, daily activities, and quality of life. " 01/01/2022 - "Predictors of Response to Oral Medications and Low-Histamine Diet in Patients with Chronic Urticaria." 12/01/2021 - "Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by an almost daily recurrence of wheal and flare with itch for more than 6 weeks, in association with the release of stored inflammatory mediators, such as histamine, from skin mast cells and/or peripheral basophils. "
10.	fexofenadine (Allegra)FDA LinkGeneric 02/01/1998 - "Fexofenadine 180 or 240mg once daily was significantly more effective than placebo in patients with chronic idiopathic urticaria. " 09/19/2008 - "These studies also support the contention that fexofenadine is effective for the treatment of allergic rhinits and chronic idiopathic urticaria." 02/01/2000 - "Although no comparative data with other H1 antagonists exist, fexofenadine 180 mg once daily was effective in reducing the symptoms of chronic idiopathic urticaria for up to 6 weeks. " 05/01/2000 - "Fexofenadine HCl is safe and effective for treatment of chronic idiopathic urticaria." 04/01/2020 - "The primary purpose of this study is to find out the efficacy of fexofenadine in the treatment of chronic idiopathic urticaria patients among the Bangladeshi population. "

Therapies and Procedures

1.	Therapeutics 06/01/2013 - "The reported case suggests a causal relationship between the positive diagnosis of Helicobacter pylori and the occurrence of chronic urticaria, showing the remission of symptoms after the institution of effective therapy for this agent. " 08/01/2011 - "However, that therapy was not always effective for treating chronic urticaria. " 04/17/2021 - "Adjunct therapy with Yimingjia® was safe and effective at 4 weeks in the treatment of chronic urticaria in children. " 03/07/2023 - "The objectives of this study/reasearch are to analyse the efficacy of autologous serum therapy in patients with chronic urticaria and compare its results in ASST(+) and ASST(-) chronic urticaria patients. " 01/01/2017 - "This study was conducted to evaluate the efficacy of autologous serum therapy (AST) among chronic urticaria patients with autologous skin prick test positive and negative status. "
2.	Aftercare (After-Treatment) 07/02/2021 - "To the best of our knowledge, this is the first study investigating TDHPs in patients with chronic spontaneous urticaria before and after treatment." 07/02/2021 - "The results of the study showed altered levels of TDHPs and their normalization after treatment with H1-antihistamines in patients with chronic spontaneous urticaria. " 05/01/2019 - "When comparing before and after treatment, statistically significant improvements in all secondary outcome measures were noted after 4 doses (UCOL score: P = .0015; visual analog scale score: P = .0108; days with symptoms: P = .0125) and after 8 doses (UCOL score: P = .0005; chronic urticaria quality of life questionnaire: P = .0105; visual analog scale score: P = .0008; and days with symptoms: P = .0144). " 01/01/2012 - "For VAS scores and total chronic urticaria impact on patients' quality of life scores, the differences between baseline and after treatment scores were significantly lower (P < 0.001, P < 0.001, respectively). " 02/21/2021 - "Changes in Urticaria Activity Score (UAS), Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL), Beck Depression Inventory (Beck-D) and Urticaria Control Test (UCT) scores were compared before and after treatment. "
3.	Bloodletting 02/01/2019 - "Many trials have shown that bloodletting therapy is effective in treating chronic urticaria. " 01/01/2019 - "Many trials have reported that bloodletting therapy is effective when treating chronic urticaria. " 01/01/2019 - "Bloodletting therapy might be an effective and safe treatment for chronic urticaria, but the evidence is scarce. " 01/01/2020 - "Efficacy of Bloodletting Therapy in Patients with Chronic Idiopathic Urticaria: A Randomized Control Trial." 02/01/2019 - "Clinical randomised controlled trials related to bloodletting therapy for treating chronic urticaria will be included, regardless of publication status and languages. "
4.	Phototherapy (Light Therapy) 04/01/2017 - "[Efficacy of phototherapy in chronic urticaria]." 06/01/2021 - "Narrow-band ultraviolet B (NB-UVB) phototherapy has been used for the treatment of chronic urticaria (CU), but the clinical efficacy of this treatment modality requires further evidence. " 05/01/2019 - "Role of Adjuvant Narrow Band Ultraviolet B Phototherapy in the Treatment of Chronic Urticaria." 01/01/2017 - "Effectiveness of phototherapy in chronic urticaria." 01/01/2008 - "Data regarding narrowband ultraviolet B (NB-UVB) phototherapy in patients with chronic urticaria is limited. "
5.	Acupuncture Therapy 02/01/2022 - "Efficacy of acupuncture treatment for chronic spontaneous urticaria: study protocol for a randomised controlled trial." 01/25/2020 - "To evaluate the efficacy of acupuncture therapy in the treatment of chronic urticaria. " 01/25/2020 - "[A Meta-analysis of acupuncture therapy for chronic urticaria]." 09/02/2015 - "This systematic review protocol aims to describe a meta-analysis to assess the effectiveness and safety of acupuncture therapy for patients with chronic urticaria. " 01/25/2020 - "Randomized controlled trials of acupuncture treatment of chronic urticaria published from January of 2008 to October of 2018 were searched from databases of CNKI, VIP, Wanfang, CBM, PubMed, Embase and Cochrane Library by using key words "urticaria or urticarias" "acupuncture therapy" "acupuncture treatment" and "randomized controlled trial (RCT)". "