Chronic Disease (Chronic Diseases)

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5237 relevant articles (183 outcomes, 432 trials/studies) found for this Disease

Description: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)

Also Known As:

Chronic Diseases; Chronic Illnesses; Disease, Chronic; Chronic Illness; Chronically Ill; Diseases, Chronic; Illness, Chronic; Illnesses, Chronic

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2442

Disease Attributes

Chronic Disease: 5237

Related Diseases

1.	Neoplasms (Cancer)
2.	Anemia
3.	Rheumatoid Arthritis
4.	Asthma (Bronchial Asthma)
5.	Infection

Experts

1.	Theurl, Igor: 2 articles (04/2008 - 05/2006)
2.	Frei, Balz: 2 articles (02/2008 - 11/2004)
3.	Kiene, Helmut: 2 articles (07/2007 - 07/2007)
4.	Willich, Stefan N: 2 articles (07/2007 - 07/2007)
5.	Glockmann, Anja: 2 articles (07/2007 - 07/2007)
6.	Ziegler, Renatus: 2 articles (07/2007 - 07/2007)
7.	Witt, Claudia M: 2 articles (07/2007 - 07/2007)
8.	Hamre, Harald J: 2 articles (07/2007 - 07/2007)
9.	Choi, Jong Weon: 2 articles (01/2007 - 01/2006)
10.	Haurani, Farid I: 2 articles (01/2006 - 04/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronic Disease:

1.	IronIBA 11/01/1977 - "In both conditions the anaemia was the result of the failure of the marrow to compensate for a modest degree of peripheral haemolysis but ineffective erythropoiesis was significantly greater in iron deficiency than in chronic disease. " 11/01/2005 - "The small dose oral iron absorption test is a potentially useful test in clinical practice and it may be helpful for the diagnosis of iron deficiency anaemia and the differential diagnosis with the anaemia of chronic disease. " 01/01/2009 - "Recent advances in our understanding of iron metabolism in patients with chronic illness and the results of clinical trials indicate that parenteral iron improves ESA response in this setting. " 01/01/2006 - "Exclusion criteria were iron therapy before and during the study period and a history of chronic illness. " 11/01/2005 - "CONCLUSION: According to our study, about half of anaemic CHF patients showed anaemia of chronic disease with blunted endogenous Epo production and/or a defective iron supply for erythropoiesis. " Order ALL the reference details at left...
2.	AntioxidantsIBA 12/29/2004 - "Antioxidants found in fruits and vegetables play an important role via their protective effects against the onset of aging-related chronic diseases. " 02/01/2009 - "Fruits and vegetables in the diet are associated with lower rates of chronic disease, and this is often attributed to their content of antioxidants, and a resulting protection against oxidative stress. " 11/01/2004 - "Efficacy of dietary antioxidants to prevent oxidative damage and inhibit chronic disease." 12/01/2008 - "Although antioxidants are being used for other chronic diseases, controlled clinical trials are warranted to investigate potential beneficial effects of antioxidants in the development of retinopathy in diabetic patients." 09/01/2008 - "The objectives of this study were to investigate the major antioxidants in persons with intellectual disability (ID) and HPO in order to find the effect of chronic disease on the level of antioxidative parameters. " Order ALL the reference details at left...
3.	FlavonoidsIBA 06/01/1998 - "Flavonoids are non-nutritive compounds of plants that have been intensively investigated during the past years due to their possible protective effects against chronic diseases. " 01/01/2003 - "In study 2 we confronted 149 regular students with differently framed messages related to a (more or less fictive) preventive dietary behaviour that was expected to be unknown to the study population, intake of flavonoids and risk for chronic disease. " 01/01/2009 - "Epidemiological evidence suggests that flavonoids may play an important role in the decreased risk of chronic diseases associated with a diet rich in plant-derived foods. " 01/16/2006 - "Flavonoids are one of the biologically active plant food constituents, possessing potential chemopreventive properties against a wide variety of chronic diseases. " 01/15/2004 - "Apples are a major source of flavonoids in the Western diet, and flavonoid-rich foods may help protect against chronic diseases by antioxidant mechanisms. " Order ALL the reference details at left...
4.	VitaminsIBA 12/01/2002 - "Subjects were participants of the Supplementation with Antioxidant Vitamins and Minerals Study, which investigates the effects of antioxidant supplementation on chronic diseases. " 10/01/2002 - "Several studies reveal a link between diets rich in fruits and vegetables containing generous amounts of vitamins E and C and lower incidence of certain chronic diseases." 06/19/2002 - "DATA SOURCES AND STUDY SELECTION: We searched MEDLINE for English-language articles about vitamins in relation to chronic diseases and their references published from 1966 through January 11, 2002. " 01/01/2009 - "CONCLUSIONS: Taking into account the high rate of potential vitamin-drug interactions, especially among older children and patients with chronic illness, parents and healthcare providers need to balance the potential benefit of concurrent vitamin-medication use with its potential harms." 11/01/2007 - "(2) The vitamin or mineral deficiencies increase sensitivity of chronic diseases. " Order ALL the reference details at left...
5.	Vitamin E FDA Link 10/01/2004 - "Vitamin E is a potent lipid-soluble antioxidant that ameliorates the oxidative stress load associated with some chronic disease conditions. " 01/01/2005 - "Clinical trials update from the American Heart Association meeting: ACORN-CSD, primary care trial of chronic disease management, PEACE, CREATE, SHIELD, A-HeFT, GEMINI, vitamin E meta-analysis, ESCAPE, CARP, and SCD-HeFT cost-effectiveness study." 12/01/2004 - "Several large-scale trials currently under way will help identify the potential benefits of vitamin E in the primary prevention of CVD and other chronic illness. " 10/01/2001 - "Large scale randomized clinical trials including healthy and low-risk subjects, along with prolonged administration of high-dose natural vitamin E, associated with synergetic compounds, and testing on morphological or biological features, will allow a better understanding of the relationship between vitamin E and chronic diseases." 07/01/2008 - "They are also a good source of minerals and vitamin E, associated with promoting health and reducing the risk for chronic disease. " Order ALL the reference details at left...
6.	polyphenolsIBA 06/01/2008 - "Polyphenols are widely distributed in plant foods, and have been linked to improved human health through reduced risk of chronic diseases, especially cardiovascular. " 10/01/2008 - "Polyphenols in general are compounds that are known to promote health and have a preventive effect against various chronic diseases. " 01/01/2008 - "Molecular effects elicited in vitro by red wine on human healthy peripheral blood mononuclear cells: potential therapeutical application of polyphenols to diet-related chronic diseases." 01/01/2008 - "All these data confirm the beneficial effects of polyphenols in some chronic diseases." 03/07/2007 - "Dietary polyphenols have been associated with reduced risk of chronic diseases, but the precise molecular mechanisms of protection remain unclear. " Order ALL the reference details at left...
7.	CalciumIBA 02/01/2006 - "BACKGROUND: Adequate intakes of calcium are required for optimal bone health and protection against chronic disease. " 10/01/1998 - "Decreasing salt consumption, increasing calcium intake, and increasing the awareness of the health value of fibre may all be beneficial in the context of chronic disease prevention." 05/01/2008 - "Dietary intake data and the controversies regarding the role calcium may play in other chronic diseases have also been discussed. " 04/01/2006 - "Higher calcium intakes not only support the skeleton in African Americans, just as they do in whites, but reduce the disease burden for other chronic diseases as well." 12/01/2005 - "Low intake of calcium and other nutrients put African-Americans at an increased risk for chronic diseases. " Order ALL the reference details at left...
8.	Carotenoids (Carotene)IBA 01/01/2007 - "This study reveals the importance of a continuous consumption of carotenoid rich foods in order to maintain high levels of plasma carotenoids for the potential prevention of chronic diseases in individuals." 12/05/2002 - "The analysis of carotenoids in plasma, foods and tissues has thus become of interest in studies examining the role of diet in chronic disease prevention and management. " 12/05/2002 - "Epidemiologic and clinical studies have shown that a high intake of vegetables and fruit, with consequently high intakes and circulating concentrations of carotenoids, is associated with reduced risk of cardiovascular and other chronic diseases. " 05/01/1996 - "Numerous observational studies have found that people who ingest more carotenoids in their diets have a reduced risk of several chronic diseases. " 03/01/2009 - "RESULTS: Mean total serum carotenoids were associated with mean walking speed over three years of follow-up (P = 0.0003) and rate of change of walking speed (P = 0.007) in multivariate linear regression models adjusting for age, body mass index, and chronic diseases. " Order ALL the reference details at left...
9.	Influenza Vaccines (FluMist)IBA 06/01/1996 - "There is overwhelming evidence for the clinical efficacy of the influenza vaccine, especially in the elderly with chronic disease, reducing mortality and hospital admissions. " 06/01/2009 - "PURPOSE: In observational studies on influenza vaccine effectiveness, confounding variables such as individual chronic diseases often are pooled before inclusion into a multivariable regression model. " 09/01/2007 - "Response of influenza vaccines against heterovariant influenza virus strains in adults with chronic diseases." 12/17/2004 - "This report summarizes the results of that survey, which indicated that approximately 63% of persons aged > or =65 years and 46% of chronically ill adults who tried to get the influenza vaccine were able to do so. " 05/01/2004 - "Availability of influenza vaccine in medical subspecialists' practices may affect vaccination rates among adults with chronic illness. " Order ALL the reference details at left...
10.	Biological Markers (Surrogate Marker)IBA 11/01/2007 - "Similarly, many studies have demonstrated a significant protection against chronic diseases from a global healthy lifestyle (HL) pattern which includes not only dietary habits but also physical activity and abstinence from smoking, whereas few data regarding the influence of a HL pattern on circulating biomarkers are available. " 02/05/2009 - "Special emphasis is given to the clinical science studies designed to investigate the effects of controlled, high-quality, energy-restricted diets on both biomarkers of longevity and on the development of chronic diseases of human aging. " 08/06/2008 - "Special emphasis will be given to the first completed clinical studies which are currently investigating the effects of controlled, high-quality energy-restricted diets on both biomarkers of longevity and on the development of chronic diseases related to age in humans. " 02/01/2008 - "PURPOSE: The purpose of the study is to investigate how patients' preferred role orientation is associated with information-seeking behavior and clinical markers of health in a chronically ill population. " 11/01/2004 - "Limitations of clinical trials in chronic diseases include a short time frame versus the long duration of disease, inclusion and exclusion criteria, use of surrogate markers that may not represent clinically relevant markers, statistical significance does not necessarily indicate clinical significance necessarily, and the fact that a control group does not assure the absence of bias. " Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/2007 - "This analysis also confirms that QoL is significantly improved in patients with chemotherapy-induced anaemia and in those with anaemia of chronic disease following erythropoietic protein therapy, with more robust evidence now available that QoL was improved in studies investigating early intervention in cases of chemotherapy- or radiotherapy-induced anaemia. " 10/01/2004 - "There is Level I evidence to show that quality-of-life (QOL) is significantly improved in patients with chemotherapy-induced anaemia and in those with anaemia of chronic disease, particularly in patients achieving a Hb response to erythropoietic protein therapy. " 05/01/2009 - "Moreover, moderate physical exercise is often more effective in treating chronic disease than drug therapy e.g. " 11/01/2008 - "Additional study is needed into the factors influencing these trends, including growth in chronic disease risk factors, greater awareness and screening, and greater affinity toward early use of drug therapy in children." 10/01/2004 - "The Hb level at which erythropoietic protein therapy should be initiated is difficult to determine as it varied between studies; a large number of Level I studies in patients with chemotherapy-induced anaemia or anaemia of chronic disease enrolled patients with a Hb concentration </=105 g/L, but none compared the effect of different baseline Hb levels on the response to treatment. " Order ALL the reference details at left...
2.	Long-Term Care 03/01/1999 - "More emphasis is required on chronic disease management, on meaningful integration between acute and long-term care services, and on improved coordination between Medicare and Medicaid initiatives. " 07/01/1998 - "Further improvement in blood pressure control at the population level will result from dealing with hard-to-solve problems, such as access to care, long-term management of a chronic disease, and societal influences on lifestyle. " 01/25/1992 - "Due to their special skills, psychiatrists can be helpful in the long term care of chronically ill children. " 05/01/1976 - "Basic to the improvement in the education of health care personnel and the staffing of all types of long-term care services are 1) the development and regular recording of information on the needs for health services of chronically ill and aged patients, emphasixing functional status and the nature of disabilities requiring assistance; 2) comprehensive medical-nursing-social evaluation of patients to determine appropriate placement and treatment; and 3) methods of classifying patient data to establish staffing requirements." 01/01/2009 - "Although the pre-post design of the present study does not allow for conclusions about comparative effectiveness, study findings suggest that anthroposophic therapies may play a beneficial role in the long-term care of children with chronic illness." Order ALL the reference details at left...
3.	Palliative Care (Palliative Medicine) 01/01/2005 - "Palliative care is medical care that provides relief from suffering and support for the best possible quality of life for patients facing advanced chronic illness and for their families. " 10/01/2003 - "CONCLUSION: Through integrating palliative care into curative care practices earlier in the disease trajectory, chronically ill patients nearing the end of life report improved satisfaction with care and demonstrate less acute care use resulting in lower costs of care. " 05/01/2007 - "Ideally, palliative care is incorporated as a priority within all aspects of each country's national health plan, so that all patients living with or dying from any chronic disease may have their suffering relieved, including children and the elderly. " 01/01/2007 - "CONCLUSION: Our results suggest that some aspects of the palliative care provided to elderly patients with end-stage chronic diseases, admitted to acute care hospitals, could be improved. " 03/01/2008 - "chronic-disease deaths occur in nursing homes, yet few studies examine palliative care quality in these settings. " Order ALL the reference details at left...
4.	Highly Active Antiretroviral Therapy (HAART) 07/01/2009 - "HAART recipients with chronic disease comorbidity were more likely to score below the general population's mean score for mental health (p = 0.007). " 07/01/2009 - "Logistic regression was used to explore the effect of sex, age, education level, income, chronic diseases, CD4 count, HAART side effects and adherence to antiretroviral drugs on recipients' physical functioning and mental health scale scores. " 09/01/2008 - "For many (not all) patients, HAART converts an inexorably fatal disease into a chronic disease with a fairly good prognosis. " 01/01/2007 - "BACKGROUND: Since the introduction of highly active antiretroviral therapy (HAART), many have learned to live with HIV as a chronic illness. " 08/01/2006 - "HAART provides one of the most cost-effective treatments for any chronic disease. " Order ALL the reference details at left...
5.	Transplants (Transplant) 11/01/2003 - "Evolutionary differences among rodents, primates, and humans; fundamental differences in the anatomy and physiology; differences in immune responses in xenotransplant models; the paucity of good transplant models of chronic disease; and allelic variability in the cells themselves make any study evaluating the efficacy of cells in transplant models difficult to interpret. " 05/25/2006 - "This study uses an exploratory approach to examine how patients with CF and their carers cope with the rigours of chronic illness and life on a transplant waiting list. " 10/01/2001 - "Further studies are needed to confirm our preliminary results and to analyze long-term effects on post-transplant lymphoproliferative disease, chronic rejection, and patient survival." 09/01/1997 - "This descriptive, qualitative study examines manifestations of the Chronic Illness and Recovery models among clinical transplant coordinators. " 07/01/1994 - "Similarities were found between the experiences of study parents and the parents of chronically ill children and parents or spouses of organ transplant recipients. " Order ALL the reference details at left...

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