Netrin-1

A netrin that binds the DCC RECEPTOR or UNC5 receptors, resulting respectively in axon attraction or repulsion. Its interaction with these receptors also prevents APOPTOSIS; it may function as a tumor suppressor protein.

Also Known As:

Networked: 610 relevant articles (35 outcomes, 111 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mehlen, Patrick: 48 articles (11/2022 - 05/2002)
2.	Kennedy, Timothy E: 26 articles (01/2022 - 01/2002)
3.	Ramesh, Ganesan: 22 articles (01/2017 - 04/2008)
4.	Flores, Cecilia: 18 articles (10/2020 - 12/2007)
5.	Bernet, Agnès: 17 articles (04/2022 - 09/2004)
6.	Eltzschig, Holger K: 12 articles (01/2021 - 02/2009)
7.	Jayakumar, Calpurnia: 12 articles (01/2015 - 03/2011)
8.	Lamarche-Vane, Nathalie: 11 articles (01/2020 - 04/2002)
9.	Paradisi, Andrea: 10 articles (11/2021 - 10/2008)
10.	Moore, Kathryn J: 10 articles (01/2021 - 10/2005)

Related Diseases

1.	Ischemic Stroke 10/01/2021 - "Elevated netrin-1 is associated with improved prognosis at 3 months after ischemic stroke in the patients with high TC levels but not in those with normal TC levels. " 11/27/2020 - "Incorporating netrin-1 to conventional risk factors improved the discriminatory power for ischemic stroke (net reclassification index = 98.0%, P < 0.001; integrated discrimination improvement = 0.28%, P = 0.027). " 01/01/2019 - "Increased Serum Netrin-1 Is Associated With Improved Prognosis of Ischemic Stroke." 01/01/2017 - "Netrin-1 Ameliorates Blood-Brain Barrier Impairment Secondary to Ischemic Stroke via the Activation of PI3K Pathway." 01/01/2023 - "This study aimed to investigate the role of microglial Netrin-1 in ischemic stroke, a topic that has not been fully understood. "
2.	Inflammation (Inflammations) 12/15/2022 - "These results suggest that subcutaneous adipose macrophage-derived netrin-1 ameliorates inflammation and ER stress in the liver, which in turn alleviates hepatic steatosis by enhancing basal PPARγ/autophagy-dependent signaling. " 12/15/2022 - "The current study investigated whether netrin-1 can attenuate hepatic steatosis through PPARγ/autophagy-mediated suppression of inflammation and endoplasmic reticulum (ER) stress in experimental animal models. " 01/01/2022 - "In this review, we will discuss the potential molecular linkage between netrin-1 and Adora2b, and explore studies demonstrating interactions between netrin-1 and Adora2b in attenuating tissue inflammation." 04/01/2020 - "The results of this study indicate that Netrin-1 and its receptor Unc5b may have essential roles in periodontal inflammation and those can be assumed as useful therapeutic agent to control inflammation and periodontal breakdown." 01/01/2018 - "In the present study, we investigated the roles of netrin-1 in the regulation of corneal epithelial wound healing, inflammation response and nerve fiber regeneration in diabetic mice and cultured corneal epithelial cells. "
3.	Ischemia 05/03/2012 - "Taken together, the present study shows that netrin-1 dose-dependently ameliorates spatial memory impairment and improves synaptic dysfunction as observed by recovery of population spike component of basal evoked potential and LTP in rats with global ischemia." 02/01/2015 - "The present study aimed to identify whether and how a novel protein, netrin-1, induces cardioprotection in vivo during ischemia/reperfusion (I/R) injury. " 12/01/2014 - "This study estimated the curative effects in chronic limb ischemia when MSCs allied with netrin-1. " 01/01/2014 - "The present study investigated whether pharmacological postconditoning with netrin-1 is cardioprotective against ischemia reperfusion (I/R) injury, and the underlying signaling mechanisms. " 05/03/2012 - "The present study was performed to investigate whether intrahippocampal administration of netrin-1 could improve spatial memory impairment in radial arm maze task and restore long-term potentiation (LTP) in 4-vessel occlusion model of global ischemia. "
4.	Neoplasms (Cancer) 06/01/2013 - "Recent studies had suggested a role mediated by PKCα for netrin-1 and its receptors in the initiation and progression of tumors. " 12/31/2023 - "The aberrant expression of the axon guidance factor, netrin-1, is observed in various types of malignancies, and it participates in the proliferation and apoptosis of tumor cells. " 10/05/2023 - "Blocking Netrin-1 Slows Cancer Progression." 10/01/2023 - "Targeting EMT in cancer through netrin-1." 08/01/2023 - "Pharmacological targeting of netrin-1 inhibits EMT in cancer."
5.	Diabetic Nephropathies (Diabetic Nephropathy) 01/01/2015 - "Moreover, whether netrin-1 is protective against diabetic kidney disease in a genetic model of nephropathy and in the nephropathy prone DBA background is also unknown. " 01/01/2015 - "Guidance cue netrin-1 was shown to have protective effects in diabetic nephropathy. " 01/01/2021 - "Diagnostic efficacy of serum and urinary netrin-1 in the early detection of diabetic nephropathy." 06/01/2020 - "This study examined netrin-1 and UNC5B expression in kidneys with diabetic kidney disease (DKD) and investigated their roles in angiogenesis. " 11/01/2016 - "This study supports that plasma netrin-1 level increases significantly when glomerular damage occurs in diabetic nephropathy."

Related Drugs and Biologics

1.	Netrin-1
2.	U 0126 (UO 126)
3.	2- phenyl- 4,4,5,5- tetramethylimidazoline- 1- oxyl- 3- oxide
4.	Biomarkers (Surrogate Marker)
5.	Monoclonal Antibodies
6.	Dexmedetomidine
7.	Peptides (Polypeptides)
8.	Peroxisome Proliferator-Activated Receptors (PPAR)
9.	DCC Receptor
10.	Small Interfering RNA (siRNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Lasers (Laser)
4.	Transplantation
5.	Immunotherapy