Netrins

A family of extracellular proteins that are related structurally to LAMININ. They function as CHEMOTACTIC FACTORS for CELL MIGRATION and AXON GUIDANCE, acting as chemoattractants for some cell types, and as chemorepellents for others.

Also Known As:

Networked: 150 relevant articles (2 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Xiong, Wen-Cheng: 6 articles (01/2021 - 01/2008)
2.	Mei, Lin: 5 articles (01/2021 - 01/2008)
3.	Gershon, Michael D: 5 articles (01/2013 - 06/2003)
4.	Ratcliffe, Elyanne M: 5 articles (01/2013 - 10/2006)
5.	Bashaw, Greg J: 4 articles (08/2015 - 03/2007)
6.	Lee, Hyun Kyoung: 4 articles (10/2008 - 10/2005)
7.	Park, Hwan Tae: 4 articles (10/2008 - 10/2005)
8.	Seo, In Ae: 4 articles (10/2008 - 10/2005)
9.	Rao, Yi: 4 articles (01/2008 - 11/2004)
10.	Tessier-Lavigne, Marc: 3 articles (11/2015 - 01/2007)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2023 - "Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors." 10/01/2021 - "Results from the SmulTCan app with the netrins-receptors gene set indicated unique hazard ratio GSs in certain renal and neural cancers, while the best subsets for this gene set, obtained via the app, could differentiate between prognostic outcomes in these cancers. " 01/01/2020 - "In this work, we used the most comprehensive database available, including more than 10000 samples across more than 30 tumor types, to analyze the six members of the netrin family. " 06/25/2018 - "Based on current research progress of our group, this review summed up recent research findings on netrins in relation to cancer biology, suggested possible mechanisms, and discussed the implications in cancer research and intervention. " 06/25/2018 - "Because of the functional diversity of netrins and the different biological effects of different receptors in tumor tissue, the specific mechanism of their action in tumors remains unclear. "
2.	Alzheimer Disease (Alzheimer's Disease) 01/01/2016 - "Finally, to support further study of netrin-1's potential as a therapeutic for Alzheimer's disease, pilot gene therapy studies were performed and a netrin mimetic peptide synthesized and tested that, like netrin, can increase sAβPPα and decrease Aβ1-42in vitro. "
3.	Colorectal Neoplasms (Colorectal Cancer) 07/24/2014 - "In this study we investigated the navigation of a set of pioneer longitudinal axons, the medial longitudinal fasciculus, in mouse embryos mutant for the Netrin/Deleted in Colorectal Cancer (DCC) attractants, and for Slit repellents, as well as the responses of explanted longitudinal axons in vitro. " 03/28/2007 - "Studies of both invertebrate and vertebrate systems support the idea that Netrin, secreted by midline cells, signals through DCC (Deleted in Colorectal Carcinoma)/UNC40/Frazzled receptors to attract commissural axons toward and across the midline, whereas Slit signals through Robo family receptors to prevent commissural axons from recrossing the midline, as well as to prevent ipsilateral axons from ever crossing. " 12/06/2022 - "Frazzled (Fra) and deleted in colorectal cancer (Dcc) are homologous receptors that promote axon attraction in response to netrin. " 11/30/2022 - "Later, during animal evolution, the last eumetazoan common ancestor (LEUMCA) acquired PGRMC phosphorylated tyrosines coincidentally with the gastrulation organizer, Netrin/deleted in colorectal carcinoma (DCC) signaling, muscle fibers, synapsed neurons, and neural recovery via a sleep-like process. " 01/01/2015 - "AMD-associated single nucleotide polymorphisms (SNPs) existed in 9 linkage disequilibrium-independent genomic regions; these included loci overlapping NTN1 (rs9899630, P ≤ 9.48 x 10(-5)), DCC (Deleted in Colorectal Cancer)--the gene encoding a primary NTN1 receptor (rs8097127, P ≤ 3.03 x 10(-5)), and 6 other netrin-related genes. "
4.	Inflammation (Inflammations) 07/01/2009 - "This study was carried out to analyze the expression of Netrins and their receptors in synovial cells of patients with RA, OA, and control subjects without synovial inflammation. " 04/01/2008 - "This study examined the impact of ischemia-reperfusion (I/R) on netrin expression and the role of netrin in preventing renal inflammation and injury. " 10/18/2022 - "Netrin (NTN)-1 exhibits pro- and anti-inflammatory roles in different settings, playing important roles in the obesity-associated low-grade chronic inflammation. " 01/01/2021 - "Additionally, we found that both MMD patient and Neo1 mutant mice exhibited altered gene expression in their cortex in proteins critical for not only angiogenesis [e.g., an increase in vascular endothelial growth factor (VEGFa)], but also axon guidance (e.g., netrin family proteins) and inflammation. " 02/07/2023 - "Netrin (NTN)-1, an extracellular matrix protein with a crucial role in inflammation, is dysregulated during obesity (OB) and influences colon cancer (CC) progression. "
5.	Schizophrenia (Dementia Praecox) 06/01/2004 - "Case-control association study of human netrin G1 gene in Japanese schizophrenia." 04/25/2008 - "Chromosome 1p13 is linked with schizophrenia in Japanese families, and one of the candidate genes in this region is the netrin G1 (NTNG1) gene at 1p13.3. Associations of 56 tag single-nucleotide polymorphisms (SNPs) with schizophrenia were explored by transmission disequilibrium analysis in 160 Japanese trios and by case-control analysis in 2,174 Japanese cases and 2,054 Japanese controls. " 06/01/2004 - "These findings suggest that netrin G1 or a nearby gene may contribute to the overall genetic risk for schizophrenia." 06/01/2004 - "To determine whether this gene is involved in the development of psychosis, we performed a genetic association study of human netrin G1 gene in schizophrenia. " 09/01/2011 - "This study aimed to investigate the potential association of netrin G1 (NTNG1) rs628117 and brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) genetic polymorphisms with susceptibility to schizophrenia. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Netrin-1
3.	Proteins (Proteins, Gene)
4.	neogenin
5.	Netrin Receptors
6.	Netrins
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
8.	Fluoxetine (Prozac)
9.	DCC Receptor
10.	Semaphorins (Semaphorin)

Related Therapies and Procedures

1.	Axotomy
2.	Nutritional Support (Artificial Feeding)
3.	Therapeutics
4.	Drug Therapy (Chemotherapy)