Diabetic Nephropathies (Diabetic Nephropathy)

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4936 relevant articles (284 outcomes, 829 trials/studies) found for this Disease

Description: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.

Also Known As:

Diabetic Nephropathy; Nephropathy, Diabetic; Diabetic Kidney Disease; Intracapillary Glomerulosclerosis; Kimmelstiel-Wilson Disease; Kimmelstiel-Wilson Syndrome; Nodular Glomerulosclerosis; Diabetic Kidney Diseases; Glomerulosclerosis, Nodular; Kidney Disease, Diabetic; Kidney Diseases, Diabetic; Kimmelstiel Wilson Disease; Kimmelstiel Wilson Syndrome; Nephropathies, Diabetic; Syndrome, Kimmelstiel-Wilson; Diabetic Glomerulosclerosis; Glomerulosclerosis, Diabetic

Relationship Network

Disease Context: Research Results

Male Urogenital Diseases

Urologic Diseases: 395

Kidney Diseases: 5158

Diabetic Nephropathies: 4936

Female Urogenital Diseases and Pregnancy Complications

Female Urogenital Diseases

Urologic Diseases: 395

Kidney Diseases: 5158

Diabetic Nephropathies: 4936

Endocrine System Diseases: 398

Diabetes Mellitus: 23818

Diabetes Complications: 2426

Diabetic Nephropathies: 4936

Related Diseases

1.	Proteinuria
2.	Hypertension (High Blood Pressure)
3.	Heart Failure
4.	Albuminuria
5.	Chronic Kidney Failure (Chronic Renal Failure)

Experts

1.	Parving, Hans-Henrik: 24 articles (09/2008 - 07/2002)
2.	Tarnow, Lise: 16 articles (09/2008 - 07/2002)
3.	Gilbert, Richard E: 13 articles (04/2008 - 06/2002)
4.	Cooper, Mark E: 13 articles (02/2008 - 03/2002)
5.	Kelly, Darren J: 13 articles (08/2007 - 03/2002)
6.	Tomino, Yasuhiko: 13 articles (02/2007 - 01/2002)
7.	Tarnow, L: 12 articles (07/2008 - 02/2000)
8.	Makino, Hirofumi: 12 articles (04/2008 - 01/2002)
9.	Rossing, Peter: 11 articles (09/2008 - 07/2002)
10.	Andersen, Steen: 10 articles (01/2006 - 07/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Diabetic Nephropathies:

1.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/01/1993 - "Strict glycemic control, and ACE inhibitors may be beneficial in early stages of diabetic nephropathy. " 01/01/2005 - "CONCLUSION: As in other causes of non-diabetic kidney disease, antihypertensive regimens with ACE inhibitors are more effective in lowering urine protein excretion in patients with advanced PKD compared to regimens without ACE inhibitors, and this benefit is greater in patients with higher levels of baseline urine protein excretion. " 01/01/2003 - "OBJECTIVE: ACE inhibitors are known to be effective in preventing the progression of diabetic nephropathy. " 07/01/2001 - "The two main treatment strategies for primary prevention of diabetic nephropathy are improved glycaemic control and blood pressure lowering, particularly using drugs such as angiotensin-converting enzyme inhibitors. " 09/01/1989 - "The relative superiority of ACE inhibitors in slowing the progression of chronic parenchymal renal disease remains to be demonstrated, although promising results have been reported in patients with diabetic nephropathy." Order ALL the reference details at left...
2.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 03/01/1995 - "In patients with diabetic nephropathy, angiotensin converting enzyme (ACE) inhibition has been shown to be more effective in this regard than conventional antihypertensive therapy. " 09/07/1996 - "OBJECTIVE: To evaluate the concept that an insertion/deletion polymorphism of the angiotensin converting enzyme gene predicts the therapeutic efficacy of inhibition of angiotensin converting enzyme on progression of diabetic nephropathy. " 04/01/1992 - "Angiotensin converting enzyme (ACE) inhibition has shown promising results in diabetic nephropathy, but long-term results on survival are not available. " 11/01/2009 - "Identification of specific angiotensin-converting enzyme variants and haplotypes that confer risk and protection against type 2 diabetic nephropathy." 07/01/2001 - "It should be recalled that development of treatment modalities occurred in reverse order: in the early 1980s, antihypertensive treatment of diabetic nephropathy was introduced, and in the early 1990s, primary and secondary prevention with improved glycaemic control and angiotensin-converting enzyme inhibition. " Order ALL the reference details at left...
3.	Insulin (Novolin)FDA Link 12/01/2004 - "Type I insulin dependent diabetic patients aged 45 or less with severe diabetic nephropathy, without immediate life saving cardiovascular risk, highly motivated and well informed achieve the best results. " 01/01/1993 - "To determine the mechanisms underlying diabetic nephropathy (DN) onset, a clinical and morphological study was initiated of 14 diabetics with insulin-dependent disease free of clinical renal manifestations. " 04/01/2009 - "A prospective study involving the use of the Diabetes Impact Management Scale (DIMS) in individuals with diabetic nephropathy as part of an interventional study of pulsatile intravenous insulin infusion therapy is used to define the utility of repeated subjective DIMS testing. " 04/01/2009 - "A prospective interventional study of pulsatile intravenous insulin infusion therapy has demonstrated reduction of left ventricular mass and blunting of progression of diabetic nephropathy. " 02/01/2009 - "Our study shows that targeting JNK to improve systemic insulin sensitivity does not necessarily prevent diabetic nephropathy." Order ALL the reference details at left...
4.	Angiotensin IIIBA 11/13/2008 - "The study also implicates that angiotensin II (AngII)-Src-Smad1 signaling pathway has played a key role for development of diabetic nephropathy. " 01/01/2006 - "These and other studies indicate that angiotensin II antagonists not only improve survival and quality of life of patients with diabetic nephropathy, but also have the potential to reduce the substantial healthcare burden associated with managing these patients. " 07/01/2003 - "Lewis study has demonstrated renoprotective effect of ACE inhibitor in type-1 diabetic nephropathy, and RENAAL and IDNT has documented that of angiotensin II type-1 receptor blocker in type-2 diabetes. " 01/01/1997 - "This and other indirect evidence from experimental animal studies suggest that the intrarenal concentration of angiotensin II may be increased as a result of increased synthesis and despite enhanced breakdown, that this peptide participates in the progression of diabetic nephropathy. " 11/13/2008 - "Intensive glycemic control and inhibition of angiotensin II delay the onset and progression of diabetic nephropathy, in part, through prevention of overproduction of ROS. " Order ALL the reference details at left...
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/30/2007 - "We hypothesized that the vascular endothelial growth factor (VEGF) participates in the pathogenesis of diabetic nephropathy and that TZD may be beneficial for the treatment of diabetic nephropathy because of the effect it has on VEGF. " 04/23/2004 - "We hypothesized that VEGF participates in the pathogenesis of diabetic nephropathy and that TZD may be beneficial for the treatment of diabetic nephropathy through its effect on VEGF. " 02/01/2006 - "BACKGROUND: Antagonism of vascular endothelial growth factor (VEGF) has improved the outcome in experimental nephropathies of various origins, including diabetic nephropathy in a type 1 diabetic rat model and a type 2 diabetic mouse model. " 12/01/2008 - "However, the promise shown in the animal studies has not carried over as convincingly into the realm of human studies, as some investigators find a negative or no relationship between VEGF and diabetic nephropathy, whereas others find a positive correlation between the two. " 05/01/2006 - "Several studies have implicated the angiogenic cytokine vascular endothelial growth factor (VEGF) in the development of diabetic nephropathy, but no data are available about its local activity during human disease. " Order ALL the reference details at left...
6.	Streptozocin (Streptozotocin)FDA Link 01/01/2009 - "Gallotannin ameliorates the development of streptozotocin-induced diabetic nephropathy by preventing the activation of PARP." 03/01/2009 - "The purpose of the present study was to investigate the effects of garlic (Allium sativum L.) on the diabetic nephropathy and oxidative stress induced by STZ (streptozotocin) in rats. " 06/01/2007 - "In the present study, the effects of thioredoxin1 (TRX1) overexpression, a small protein with antioxidant property, on the development of diabetic nephropathy in streptozotocin-induced diabetic animals were investigated using TRX1 transgenic mice (TRX1-Tg). " 01/01/2007 - "In the present study, the relationship between diabetic nephropathy and Txnip was investigated using streptozotocin (STZ)-induced diabetic mice. " 02/01/2006 - "The present study was undertaken to characterize the effects of this preparation on diabetic nephropathy using streptozotocin-diabetic rats as a model. " Order ALL the reference details at left...
7.	Angiotensin Receptors (Angiotensin II Receptor)IBA 08/01/2005 - "Recent clinical trials have supported the use of angiotensin II receptor antagonists in the treatment of diabetic nephropathy, resulting in the approval of new therapeutic indications in the US and Europe. " 08/07/2004 - "Several studies have found that angiotensin-II receptor antagonists have a renoprotective effect in type 2 diabetics with diabetic nephropathy, independently of their antihypertensive effects. " 03/01/2004 - "Recent clinical trials have supported the use of angiotensin II receptor antagonists in the treatment of diabetic nephropathy, resulting in the approval of new therapeutic indications in the United States and Europe. " 08/01/2003 - "Renoprotective effects of adding angiotensin II receptor blocker to maximal recommended doses of ACE inhibitor in diabetic nephropathy: a randomized double-blind crossover trial." 07/01/2009 - "Effects of angiotensin II receptor blockers on diabetic nephropathy." Order ALL the reference details at left...
8.	Transforming Growth Factor beta (TGF-beta)IBA 05/01/1999 - "Rather, interception of the effects of TGF-beta seems to be an approach most likely to yield beneficial results in diabetic nephropathy." 01/01/2001 - "Nevertheless, it is hoped that further studies to elucidate the efficacy of novel interventions to intercept the activity of the renal TGF-beta system will prove useful for effectively halting the progression of diabetic nephropathy." 01/03/2003 - "Anti-TGF-beta regimens would be useful in the treatment of diabetic nephropathy." 11/01/2008 - "Efficacy of gene therapy for transforming growth factor-beta in progressive diabetic nephropathy." 12/01/2008 - "CONCLUSIONS: In summary, the present study suggests a functional activity of the TSP-1/TGF-beta axis, especially in the tubulointerstitium of patients with diabetic nephropathy. " Order ALL the reference details at left...
9.	AngiotensinsIBA 03/01/2008 - "Clinical trials have found angiotensin receptor blockers (ARBs) to be more beneficial than traditional antihypertensive therapy in patients with type 2 diabetic nephropathy (DN). " 08/01/2007 - "The alterations in the signal pathways discussed in this review give support to the observational studies and clinical assays, where metabolic and antihypertensive controls obtained with angiotensin-converting inhibitors have shown important and additive effect in the prevention of the beginning and progression of diabetic nephropathy. " 08/01/2002 - "Recent studies in patients with type 2 diabetes indicate a significant delay in progression or development of diabetic nephropathy following blockade of the renin-angiotensin-aldosterone system with the use of angiotensin receptor antagonists. " 01/01/2002 - "With the reports of recently completed trials examining the role of angiotensin receptor blockers (ARBs) in type 2 diabetic nephropathy, the question has arisen as to which agents are best to block the RAS in type 2 diabetes. " 01/01/2002 - "These trials all had a common theme--that is, does an angiotensin receptor blocker (ARB) interfere with the natural history of diabetic nephropathy in a blood pressure-independent fashion? " Order ALL the reference details at left...
10.	Losartan (Cozaar)FDA Link 01/01/2001 - "CONCLUSION: Antihypertensive treatment with losartan exerts a beneficial effect on UAE, a benchmark for measuring the efficacy of therapeutic interventions in diabetic nephropathy, by reducing BP and allowing better diabetes control. " 12/01/2004 - "Continuum of renoprotection with losartan at all stages of type 2 diabetic nephropathy: a post hoc analysis of the RENAAL trial results." 08/07/2004 - "The RENAAL study demonstrated the clinical benefits of losartan in patients with DM type 2 and advanced diabetic nephropathy. " 10/01/2002 - "In a separate study, losartan was shown to reduce the risk for progression of renal disease in patients with type 2 diabetic nephropathy. " 08/01/2002 - "CONCLUSION: Our study suggests that the optimal dose of losartan is 100 mg daily for renoprotection and blood pressure reduction in type 1 diabetic patients with diabetic nephropathy." Order ALL the reference details at left...

Therapies and Procedures

1.	Pancreas Transplantation 02/01/1995 - "Combined kidney and pancreas transplantation is a safe and effective treatment option for diabetic nephropathy. " 05/01/2001 - "Resolution of renal lesions (62%) has been claimed in a single study and in a small number of patients with diabetic nephropathy after 10-year pancreas transplantation. " 11/01/2008 - "Combined kidney-pancreas transplantation is the treatment of choice for end-stage diabetic nephropathy. " 01/01/2007 - "Combined kidney-pancreas transplantation is the treatment of choice for end-stage diabetic nephropathy. " 01/01/2007 - "Tight glycemic control can reduce progression of diabetic nephropathy (DN) while the histological changes may regress after pancreas transplantation. " Order ALL the reference details at left...
2.	Kidney Transplantation 03/01/2004 - "Today, simultaneous pancreas and kidney transplantation is the gold standard procedure for end-stage type 1 diabetic nephropathy recipients." 06/01/1984 - "Improved results of renal transplantation in diabetic nephropathy." 08/01/2009 - "A long-term prevention of diabetic nephropathy in a patient with type 1 diabetes after simultaneous pancreas and kidney transplantation." 08/01/2009 - "Japan A 56-yr-old Japanese male with a history of diabetic nephropathy underwent a HLA 5/6 mismatch and ABO-compatible living-related kidney transplantation (donor: his 49-yr-old wife). " 08/01/2009 - "In FinnDiane, diabetic nephropathy was defined as urinary albumin excretion > or = 300 mg/24 h, dialysis, or renal transplantation. " Order ALL the reference details at left...
3.	Protein-Restricted Diet (Diet, Protein Restricted) 08/01/2001 - "RESULTS AND CONCLUSIONS: Low and very low-protein diets associated with specific enteral supplements are indicated in most patients with chronic renal disease and in patients with incipient diabetic nephropathy to slow progression of disease and to improve their overall status, contributing to improved survival (grade A recommendation). " 02/01/2006 - "Reduction of urinary protein levels by various medications and a low-protein diet limits renal function decline in individuals with nondiabetic and diabetic nephropathies to the point that remission of the disease and regression of renal lesions have been observed in experimental animals and even in humans. " 09/01/2008 - "Low-protein diet for diabetic nephropathy: a meta-analysis of randomized controlled trials." 07/01/1993 - "This study was designed to clarify the mechanisms by which the progression of diabetic nephropathy is inhibited by low-protein diet. " 10/01/2009 - "We assessed whether a low-protein diet could prevent the progression of diabetic nephropathy. " Order ALL the reference details at left...
4.	Renal Dialysis (Hemodialysis) 01/01/2008 - "Therapeutic options such as strict blood pressure and/or glycemic control are effective for preventing the development and progression of diabetic nephropathy, but the number of diabetic patients on hemodialysis is still increasing. " 06/01/2009 - "The present study reports the difficulties in early diagnosis of an extrapulmonary TBC case, as it happened to a 53-year-old man with diabetic nephropathy who started on regular hemodialysis for 5 months. " 02/01/2001 - "The purpose of this study is to clarify the role of diabetic nephropathy on outcomes of a group of patients on chronic hemodialysis undergoing CABG. " 07/01/2008 - "OBJECTIVES: To evaluate the influence of hemodialysis on cardiovascular risk factors and on their frequency in diabetic nephropathy patients. " 01/01/2008 - "CONCLUSION: Our data indicate that mortality of hemodialysis patients with type-2 diabetic nephropathy is influenced neither by dialyzer flux level nor by biocompatibility." Order ALL the reference details at left...
5.	Transplants (Transplant) 02/01/1990 - "While a renal graft allows improved detection of pancreas rejection, a pancreatic graft confers protection against recurrence of diabetic nephropathy. " 01/01/2009 - "METHODS: We studied renal biopsy specimens of 22 patients with diabetic nephropathy and 11 transplant donors as normal controls. " 01/01/2008 - "In the case of a cadaver donor, early kidney transplant can be an ideal option for all candidates, but in particular for children and patients with diabetic nephropathy. " 11/01/2007 - "We speculate that long exposure to smoking may be the etiologic factor for nodular glomerulosclerosis in the kidney graft of our patient. " 05/01/2007 - "Kidney function after islet transplant alone in type 1 diabetes: impact of immunosuppressive therapy on progression of diabetic nephropathy." Order ALL the reference details at left...

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