DCC Receptor

A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells.

Also Known As:

Networked: 64 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Flores, Cecilia: 7 articles (01/2020 - 06/2011)
2.	Mehlen, Patrick: 6 articles (01/2021 - 08/2004)
3.	Cooper, Helen M: 4 articles (01/2018 - 06/2011)
4.	Meijers, Rob: 3 articles (01/2020 - 08/2014)
5.	Wang, Jia-Huai: 3 articles (01/2020 - 08/2014)
6.	Zhang, Yan: 3 articles (01/2020 - 08/2014)
7.	Eng, Conrad: 3 articles (01/2018 - 06/2011)
8.	Manitt, Colleen: 3 articles (01/2018 - 06/2011)
9.	Lamarche-Vane, Nathalie: 3 articles (02/2009 - 04/2002)
10.	Kania, Artur: 2 articles (01/2022 - 01/2018)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2020 - "The Deleted in Colorectal Carcinoma (Dcc) receptor plays a critical role in optic nerve development. " 01/01/2018 - "The axon guidance cue receptor DCC (deleted in colorectal cancer) plays a critical role in the organization of mesocorticolimbic pathways in rodents. " 01/01/2018 - "Draxin was expressed in Tbr2 (+) late progenitors and NeuroD1 (+) neuroblasts in the dentate granule cell lineage, whereas expression of its receptor DCC (deleted in colorectal cancer) was mainly detectable in neuroblasts. " 08/19/2015 - "After initial attraction to the floor plate using Netrin1 activation of its main attractive receptor, DCC (deleted in colorectal cancer), axons cross the ventral midline, and many turn to grow longitudinally on the contralateral side. " 03/13/2015 - "The guidance cue receptor, DCC (deleted in colorectal cancer), is highly expressed by dopamine neurons and orchestrates their innervation to the mPFC during adolescence. "
2.	Parkinson Disease (Parkinson's Disease) 01/01/2022 - "The netrin-1 receptor DCC promotes the survival of a subpopulation of midbrain dopaminergic neurons: Relevance for ageing and Parkinson's disease." 01/01/2021 - "Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features."
3.	Pain (Aches) 01/01/2022 - "Among 23 loci associated with multisite pain, nine loci replicated in the HUNT cohort, with the DCC netrin 1 receptor (DCC) as the top gene. " 01/01/2019 - "Moreover, we demonstrated a possible role for netrin-1 secreted by osteoclasts during aberrant subchondral bone remodeling in inducing sensory innervation and OA pain through its receptor DCC (deleted in colorectal cancer). "
4.	Ovarian Neoplasms (Ovarian Cancer) 05/01/2011 - "Our purpose was to investigate whether NTN1 and its receptor DCC may be involved in ovarian cancer. " 12/01/2006 - "Automated quantitative analysis of DCC tumor suppressor protein in ovarian cancer tissue microarray shows association with beta-catenin levels and outcome in patients with epithelial ovarian cancer."
5.	Neoplasms (Cancer) 02/27/2015 - "Netrin-1, acting through its principal receptor DCC (deleted in colorectal cancer), serves as an axon guidance cue during neural development and also contributes to vascular morphogenesis, epithelial migration, and the pathogenesis of some tumors. " 08/16/2007 - "Opposing roles of netrin-1 and the dependence receptor DCC in cancer cell invasion, tumor growth and metastasis."

Related Drugs and Biologics

1.	Netrin-1
2.	U 0126 (UO 126)
3.	2- phenyl- 4,4,5,5- tetramethylimidazoline- 1- oxyl- 3- oxide
4.	Netrins
5.	ErbB Receptors (EGF Receptor)
6.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
7.	ezrin
8.	Proteins (Proteins, Gene)
9.	Ligands
10.	Dopamine (Intropin)

Related Therapies and Procedures

1.	Transjugular Intrahepatic Portasystemic Shunt
2.	Transplantation