Hyperfunctioning Thyroid Adenoma

associated with mutations in TSHR gene

Also Known As:

Thyroid Adenoma, Hyperfunctioning; Thyroid Carcinoma With Thyrotoxicosis

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Papillary Thyroid Cancer
2.	Graves Disease (Basedow Disease)
3.	Hyperthyroidism
4.	Neoplasms (Cancer)

Experts

1.	Araki, O: 1 article (07/2001)
2.	Hosoi, Y: 1 article (07/2001)
3.	Kamiya, Y: 1 article (07/2001)
4.	Mizuma, H: 1 article (07/2001)
5.	Mori, M: 1 article (07/2001)
6.	Morimura, T: 1 article (07/2001)
7.	Murakami, M: 1 article (07/2001)
8.	Ogiwara, T: 1 article (07/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hyperfunctioning Thyroid Adenoma:

1.	Gs GTP-Binding Protein alpha Subunits (G(s)alpha)IBA 07/01/2001 - "Three cases with hyperfunctioning thyroid adenoma, including a case that showed an activating mutation of G(s)alpha with a constitutive activation of cAMP production in cultured cells, and six cases with papillary thyroid carcinoma were analyzed in the present study. " 07/01/2001 - "In summary, these results suggest that DII expression in human thyroid gland is regulated at the transcriptional level through the TSH receptor-G(s)alpha-cAMP regulatory cascade, which may be related to the increase in circulating T(3) level in patients with Graves' disease and hyperfunctioning thyroid adenoma."
2.	Thyrotropin Receptors (Thyrotropin Receptor)IBA 11/01/1999 - "Hyperfunctioning thyroid adenoma and activating mutations in the TSH receptor gene." 07/01/2001 - "In summary, these results suggest that DII expression in human thyroid gland is regulated at the transcriptional level through the TSH receptor-G(s)alpha-cAMP regulatory cascade, which may be related to the increase in circulating T(3) level in patients with Graves' disease and hyperfunctioning thyroid adenoma." 02/01/1999 - "In this paper we described the appearance of TSH-receptor antibodies and the concomitant development of persistent hyperthyroidism in a patient with hyperfunctioning thyroid adenoma after 131I treatment. " 02/01/1999 - "Appearance of anti TSH-receptor antibodies and clinical Graves' disease after radioiodine therapy for hyperfunctioning thyroid adenoma." 03/16/1998 - "We analyzed cultured cells from hyperfunctioning thyroid adenoma and its surrounding thyroid tissue from a Japanese woman and determined the nucleotide sequences of genes encoding the alpha subunit of the stimulatory G-protein 1 (G alphas) and thyrotropin (TSH) receptor in its tumor tissue. "
3.	Ethanol (Ethyl Alcohol)IBA 06/01/1996 - "Morphological changes in a hyperfunctioning thyroid adenoma after percutaneous ethanol injection: histological, enzymatic and sub-microscopical alterations." 05/01/1997 - "Appearance of Graves' disease after percutaneous ethanol injection for the treatment of hyperfunctioning thyroid adenoma." 05/01/1997 - "In this report we describe an unusual patient with hyperfunctioning thyroid adenoma in whom percutaneous ethanol injection (p.e.i.) therapy was followed by typical Graves' disease. "
4.	GTP-Binding Proteins (G-Protein)IBA 03/16/1998 - "We analyzed cultured cells from hyperfunctioning thyroid adenoma and its surrounding thyroid tissue from a Japanese woman and determined the nucleotide sequences of genes encoding the alpha subunit of the stimulatory G-protein 1 (G alphas) and thyrotropin (TSH) receptor in its tumor tissue. "
5.	Triiodothyronine (Liothyronine)FDA LinkGeneric 01/01/1976 - "Normal concentrations of total serum thyroxine (T4) and triiodothyronine (T3) were found in a patient who was hyperthyroid because of a hyperfunctioning thyroid adenoma. "
6.	Thyroxine (Levothyroxine)FDA LinkGeneric 01/01/1976 - "Normal concentrations of total serum thyroxine (T4) and triiodothyronine (T3) were found in a patient who was hyperthyroid because of a hyperfunctioning thyroid adenoma. "
7.	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 03/16/1998 - "We analyzed cultured cells from hyperfunctioning thyroid adenoma and its surrounding thyroid tissue from a Japanese woman and determined the nucleotide sequences of genes encoding the alpha subunit of the stimulatory G-protein 1 (G alphas) and thyrotropin (TSH) receptor in its tumor tissue. "
8.	Messenger RNA (mRNA)IBA 07/01/2001 - "DII mRNA and DII activity in hyperfunctioning thyroid adenoma were significantly increased compared with those in nontumor tissue in each case. "
9.	Type C PhospholipasesIBA 03/16/1998 - "These results suggest that cAMP regulatory cascade is constitutively activated while phospholipase C-Ca2+ signaling cascade is suppressed in hyperfunctioning thyroid adenoma with an activating mutation of G alphas gene in the present case."
10.	Choline (Choline Chloride)IBA 06/23/1952 - "[Effects of choline in hyperfunctioning thyroid adenoma in a child]."

Therapies and Procedures

Therapeutics

02/01/1964 - "[NEW DATA ON THE CLINICAL DIAGNOSIS AND THERAPY OF HYPERFUNCTIONING THYROID ADENOMA]."
05/01/1997 - "In this report we describe an unusual patient with hyperfunctioning thyroid adenoma in whom percutaneous ethanol injection (p.e.i.) therapy was followed by typical Graves' disease. "
02/01/1999 - "Appearance of anti TSH-receptor antibodies and clinical Graves' disease after radioiodine therapy for hyperfunctioning thyroid adenoma."