Thyrotropin Receptors (Thyrotropin Receptor)

Subscribe to Selected New Research on Thyrotropin Receptors

1365 relevant articles (27 outcomes, 117 trials/studies) found for this Bio-Agent

Description: Cell surface proteins that bind pituitary THYROTROPIN (also named thyroid stimulating hormone or TSH) and trigger intracellular changes of the target cells. TSH receptors are present in the nervous system and on target cells in the thyroid gland. Autoantibodies to TSH receptors are implicated in thyroid diseases such as GRAVES DISEASE and Hashimoto disease (THYROIDITIS, AUTOIMMUNE).

Also Known As:

Thyrotropin Receptor; TSH Receptor; Receptors, Thyrotropin; LATS Receptors; Receptor, LATS Immunoglobulins; Receptors, LATS; Receptors, Long-Acting Thyroid Stimulator; Receptors, TSH; Thyroid Stimulating Hormone Receptor; Receptor, TSH; Receptor, Thyrotropin; Receptors, Long Acting Thyroid Stimulator; Receptors, Thyroid Stimulating Hormone; TSH Receptors; Thyroid Stimulating Hormone Receptors

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins

Proteins: 58433

Membrane Proteins: 4125

Cell Surface Receptors: 552

Peptide Receptors: 308

Neuropeptide Receptors: 48

Thyrotropin Receptors: 1365

thyrotropin receptor (256-275)

Pituitary Hormone Receptors

Thyrotropin Receptors: 1365

thyrotropin receptor (256-275)

Neurotransmitter Receptors: 284

Neuropeptide Receptors: 48

Thyrotropin Receptors: 1365

thyrotropin receptor (256-275)

Experts

1.	McLachlan, Sandra M: 8 articles (07/2008 - 06/2003)
2.	Rapoport, Basil: 8 articles (07/2008 - 06/2003)
3.	Chen, Chun-Rong: 7 articles (06/2006 - 06/2003)
4.	Amino, Nobuyuki: 6 articles (01/2007 - 04/2003)
5.	Morgenthaler, Nils G: 5 articles (03/2007 - 08/2002)
6.	Morgenthaler, N G: 5 articles (01/2007 - 12/2000)
7.	Vassart, G: 5 articles (09/2004 - 03/2000)
8.	Paschke, R: 5 articles (12/2003 - 01/2001)
9.	Vitti, P: 5 articles (10/2003 - 03/2000)
10.	Pinchera, A: 5 articles (10/2003 - 03/2000)

Related Diseases

1.	Graves Disease (Basedow Disease) 02/01/2004 - "The aim of this study was to evaluate the ability of the more sensitive second-generation TSH receptor (TRAb) assay to predict recurrent Graves' disease (GD) vs. remission depending on TRAb levels. " 01/01/2008 - "CONCLUSION: The majority of patients with Graves' disease gradually enter remission of TSH-receptor autoimmunity during medical or after surgical therapy, with no difference between the types of therapy. " 09/01/1989 - "Increased activated T-lymphocytes and normal thyrotropin receptor antibody levels in Graves' disease in long-term remission." 01/01/1989 - "It is hoped that understanding of Graves' disease will benefit from improvement in our knowledge of the TSH receptor structure and functions." 10/01/1985 - "Improved receptor and bioassays have been used to compare TSH receptor binding and thyroid stimulating activities in unextracted sera from 110 patients with Graves' disease. " Order ALL the reference details at left...
2.	Hyperthyroidism 02/01/2006 - "Adenovirus encoding the thyrotropin receptor A-subunit improves the efficacy of dendritic cell-induced Graves' hyperthyroidism in mice." 01/01/2006 - "Our previous studies using HEK-293 cells expressing the extracellular domain of the TSH receptor (TSHR) showed that Stat4-/- mice, which lack Th1 cells, are susceptible, whereas Stat6-/- mice, which lack Th2 cells, are resistant to the induction of Graves' hyperthyroidism. " 08/01/2009 - "CONTEXT: Constitutive mutations of the TSH receptor gene are a rare cause of severe congenital hyperthyroidism. " 08/01/2009 - "Graves'-like hyperthyroidism is induced by immunizing BALB/c mice with adenovirus expressing the thyrotropin receptor (TSHR) or its A-subunit. " 04/01/2009 - "OBJECTIVE: To describe clinical and genetic features of a Thai family with non-autoimmune hyperthyroidism (NAH) caused by an activating germline mutation in the thyrotropin receptor (TSHR) gene. " Order ALL the reference details at left...
3.	Hypothyroidism 02/01/2009 - "Functional studies of new TSH receptor (TSHr) mutations identified in patients affected by hypothyroidism or isolated hyperthyrotrophinaemia." 02/01/2007 - "In this view, the study of association between subclinical hypothyroidism and possible molecular effectors, such as polymorphisms in the TSH receptor (TSHR) gene, could be interesting. " 03/01/2009 - "No difference between groups was observed in prevalence of TSH receptor autoantibody (14.7, 5.6, 14.7, and 8.3%) or duration of symptoms before hypothyroidism was diagnosed. " 11/01/2008 - "The mutant hyt/hyt mouse, characterized by fetal-onset, life-long hypothyroidism resulting from a point mutation of the thyroid-stimulating hormone receptor of the thyroid gland, displays a variety of abnormalities in motor behavior that are likely associated with dysfunctions of specific brain regions and a defective corticospinal tract (CST). " 11/01/2007 - "CONCLUSIONS: We identified TSH receptor mutations in seven members of three families with subclinical hypothyroidism." Order ALL the reference details at left...
4.	Hashimoto Disease (Thyroiditis, Hashimoto) 10/01/1996 - "RESULTS: TSH receptor transcript levels were higher in Graves' disease than in Hashimoto's disease and healthy control. " 04/01/1998 - "RESULTS: TSH receptor Abs were detected by bioassay in 10 (91%) of 11 patients with active Graves disease but in 0 of 2 patients in remission, 0 of 13 normal members of the control group, and 0 of 11 patients with chronic lymphocytic thyroiditis including 1 with thyrotoxicosis. " 05/01/1986 - "The assay detected TSH receptor antibodies in 81 of 85 patients (95%) with untreated Graves' disease, no patients with Graves' disease in remission, and 7 of 57 patients (12%) with Hashimoto's disease. " 12/01/2009 - "Diagnosis and discrimination of autoimmune Graves' disease and Hashimoto's disease using thyroid-stimulating hormone receptor-containing recombinant proteoliposomes." 02/01/2003 - "The role of stimulating, function-blocking and growth-blocking anti-TSH receptor antibodies (TRAbs) in GD, Hashimoto's disease and in atrophic thyroiditis." Order ALL the reference details at left...
5.	Thyrotoxicosis 05/01/2008 - "Persistent neonatal thyrotoxicosis in a neonate secondary to a rare thyroid-stimulating hormone receptor activating mutation: case report and literature review." 09/01/2004 - "AIM: To ascertain the prevalence of germline mutations in the TSH receptor gene as a cause of juvenile thyrotoxicosis (JT) in non-autoimmune patients. " 09/01/2004 - "Prevalence of germline mutations in the TSH receptor gene as a cause of juvenile thyrotoxicosis." 10/01/1999 - "A novel thyrotropin receptor mutation in an infant with severe thyrotoxicosis." 08/01/1999 - "Thyrotoxicosis develops differently in these two disorders: GD stimulates TSH receptors through antibody binding, while ST destroys follicles, probably through an autoimmune mechanism. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Antibodies
2.	Autoantibodies
3.	Thyrotropin (Thyroid-Stimulating Hormone)
4.	Thyroglobulin
5.	Thyroid-Stimulating Immunoglobulins
6.	Hormones
7.	Thyroxine (Levothyroxine)
8.	Carbimazole
9.	HLA-DR Antigens (HLA-DR)
10.	N 30

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Thyroidectomy
3.	Aftercare (After-Treatment)
4.	Transplants (Transplant)
5.	Intramuscular Injections

Best Treatments:
Research Summary Report
on Graves Disease

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. CureHunter research summary reports will vary in length from 25 to 250 pages. Analytic charts allow you and your physicians to see at a glance your medication options—including new, promising, off-label and experimental all rated for clinical efficacy.

Free Updates for 1 Year
All 217 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Reference Details
Sample PDF Report on Psoriasis >>

Price:

$24.00 & Delivery via PDF download
updates for 1 year

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>