Abstract | OBJECTIVE: METHODS: In a cross-sectional study, we included 82 consecutive patients (75 female and seven male; mean age 61 yr; range 33-87 yr) attending our unit. All patients fulfilled four or more of the diagnostic criteria for SS proposed by the European Community Study Group in 1993. Extraglandular manifestations such as arthralgia and/or arthritis, Raynaud's phenomenon, autoimmune thyroiditis, peripheral neuropathy, renal involvement and cutaneous vasculitis were also recorded. Serum samples were examined by indirect immunofluorescence (IIF) and by ELISA using as substrates myeloperoxidase (MPO) and proteinase 3 (PR3). RESULTS: CONCLUSION:
ANCA positivity can be found in patients with primary SS and its detection is associated with the presence of clinical manifestations attributable to vascular involvement ( cutaneous vasculitis, peripheral neuropathy and Raynaud's phenomenon).
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Authors | J Font, M Ramos-Casals, R Cervera, X Bosch, E Mirapeix, M García-Carrasco, R M Morlà, M Ingelmo |
Journal | British journal of rheumatology
(Br J Rheumatol)
Vol. 37
Issue 12
Pg. 1287-91
(Dec 1998)
ISSN: 0263-7103 [Print] England |
PMID | 9973150
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Antineutrophil Cytoplasmic
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Antineutrophil Cytoplasmic
(analysis)
- Cross-Sectional Studies
- Female
- Humans
- Male
- Middle Aged
- Prevalence
- Seroepidemiologic Studies
- Sjogren's Syndrome
(epidemiology, immunology)
- Skin
(blood supply, immunology)
- Vasculitis
(epidemiology, immunology)
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