Secretoneurin in carcinoids of the appendix-immunohistochemical comparison with chromogranins A,B and secretogranin II.

Abstract

BACKGROUND:

The aim of the present study was to investigate immunohistochemically the distribution of secretoneurin, a novel 33 amino acid peptide, in comparison to chromogranin A, chromogranin B, and secretogranin II in carcinoids of the appendix.

MATERIALS AND METHODS:

Paraffin-embedded tissues from 47 carcinoids were incubated with antibodies specific for chromogranin A, chromogranin B, the secretogranin II derived peptide LF- 19, and secretoneurin.

RESULTS:

44 tumors (94%) were positive for secretoneurin, whereas only 39 tumors (83%) were immunoreactive for chromogranin A. There was no significant correlation between neuropeptide expression and type of carcinoid, tumor size, vascular infiltration, serosal involvement or mesoappendiceal infiltration.

CONCLUSIONS:

Our investigations revealed that secretoneurin is detected more frequently than chromogranin A in carcinoids of the appendix. This supports the theory that tumor cells of appendiceal carcinoids are of a different origin than other midgut carcinoids. No special tumor entity with a characteristic secretoneurin-chromogranin pattern could be identified.

• Authors: R Prommegger, P Obrist, C Ensinger, H G Schwelberger, C Wolf, R Fischer-Colbrie, G Mikuz, E Bodner
• Journal: Anticancer research (Anticancer Res) 1998 Nov-Dec Vol. 18 Issue 6A Pg. 3999-4002 ISSN: 0250-7005 [Print] Greece
• PMID: 9891437 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antigens, CD
• Chromogranin A
• Chromogranins
• Neuropeptides
• Platelet Endothelial Cell Adhesion Molecule-1
• Proteins
• Secretogranin II
• secretoneurin

Topics

• Antigens, CD
• Appendiceal Neoplasms (pathology)
• Carcinoid Tumor (pathology)
• Chromogranin A
• Chromogranins (analysis)
• Humans
• Immunohistochemistry
• Neuropeptides (analysis)
• Platelet Endothelial Cell Adhesion Molecule-1 (analysis)
• Proteins (analysis)
• Retrospective Studies
• Secretogranin II