[Medicamentous therapy of alcoholic polyneuropathy. Randomized double-blind study comparing 2 vitamin B preparations and a nucleotide preparation].

Abstract

In a randomized double-blind study involving 303 patients with alcoholic polyneuropathy the efficacy and tolerability of the combinations thiamine/pyridoxine, benfotiamine/pyridoxine, and the nucleotides of cytidine and uridine administered orally for 21 days were compared. Pain and paraesthesia, measured on a visual 10-cm-long analogue scale, as also pallaesthesia and the strength of the dorsiflexion and plantar flexors of the foot, clearly improved in all treatment groups. Clinically relevant differences in efficacy were not observed. All the drugs tested were well tolerated.

• Authors: C Kretschmar, S Kaumeier, W Haase
• Journal: Fortschritte der Medizin (Fortschr Med) Vol. 114 Issue 32 Pg. 439-43 (Nov 20 1996) ISSN: 0015-8178 [Print] Germany
• Vernacular Title: Die medikamentöse Therapie der alkoholischen Polyneuropathie. Randomisierte Doppelblindstudie zum Vergleich zweier Vitamin-B-Präparate und eines Nukleotid-Präparates.
• PMID: 9064269 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Cytidine
• Pyridoxine
• Uridine
• Thiamine
• benphothiamine

Topics

• Adult
• Alcoholism (complications, rehabilitation)
• Cytidine (administration & dosage)
• Double-Blind Method
• Drug Administration Schedule
• Drug Therapy, Combination
• Female
• Humans
• Male
• Peripheral Nervous System Diseases (drug therapy)
• Pyridoxine (administration & dosage)
• Thiamine (administration & dosage, analogs & derivatives)
• Treatment Outcome
• Uridine (administration & dosage)