Pyridoxine (Pyridoxin)

The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).

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Networked: 1431 relevant articles (83 outcomes, 138 trials/studies)

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Drug Context: Research Results

Experts

1.	Jakobs, Cornelis: 20 articles (12/2013 - 03/2006)
2.	Koren, Gideon: 14 articles (07/2015 - 05/2002)
3.	Gospe, Sidney M: 13 articles (04/2014 - 03/2002)
4.	Struys, Eduard A: 10 articles (11/2014 - 10/2007)
5.	Struys, Eduard: 10 articles (04/2014 - 03/2006)
6.	Clayton, Peter T: 9 articles (10/2015 - 04/2005)
7.	Plecko, Barbara: 8 articles (05/2014 - 03/2006)
8.	Bok, Levinus A: 8 articles (11/2012 - 08/2007)
9.	Mills, Philippa B: 7 articles (10/2015 - 04/2005)
10.	Iezhitsa, I N: 7 articles (04/2013 - 09/2003)

Related Diseases

1.	Seizures (Seizure) 01/01/2013 - "While PLP would be effective in all four disorders, pyridoxine fails to treat seizures in PNPO deficiency. " 03/01/2010 - "These results suggest that antenatal pyridoxine supplementation may be effective in preventing intrauterine seizures, decreasing the risk of complicated birth and improving neurodevelopmental outcome in PDS." 11/01/2010 - "Efficacy of pyridoxine in early-onset idiopathic intractable seizures in children." 03/01/2000 - "Early diagnosis and treatment of pyridoxine-dependent seizures is essential for an improved neurologic outcome." 08/19/1995 - "A newborn girl with seizures was, after repeated conventional anticonvulsive treatment, cured by pyridoxine administration. "
2.	Nausea 09/01/1995 - "Pyridoxine is effective in relieving the severity of nausea in early pregnancy." 09/01/1995 - "There was a significant decrease in the mean of posttherapy minus baseline nausea scores in the pyridoxine compared with that in the placebo group (t test, p = 0.0008). " 08/01/1986 - "Pyridoxine is considered safe for use during pregnancy, but its efficacy in treating nausea and vomiting has not been determined. " 09/01/1995 - "Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial." 03/01/1998 - "Loss of appetite (0% versus 1.9%), nausea (11.5% versus 21.1%) and vomiting (21.1% versus 28.8%) were lower for pyridoxine treated patients than for control patients. "
3.	Peripheral Nervous System Diseases (PNS Diseases) 01/01/2013 - "In conclusion, findings of the present study demonstrate that treatment with fenugreek seed extract can potentially facilitate healing from pyridoxine induced peripheral neuropathy in mice. " 07/01/1992 - "This study suggests that (1) there is a clear dose-percent relationship for pyridoxine-induced neuropathy, (2) QST is a sensitive measurement for detecting early peripheral neuropathy; QST abnormalities may precede changes in nerve conduction studies, (3) coasting appears unrelated to persistently elevated blood levels of the toxin, and (4) a dose-dependent vulnerability may exist among nerve fibers of different caliber when exposed to an axonal toxin, such as pyridoxine." 09/01/2014 - "Based on the current limited data, it can be concluded that very low doses of daily pyridoxine are required to prevent peripheral neuropathy. " 05/28/2014 - "Peripheral neuropathy was induced by intraperiotoneal injection of high doses of pyridoxine in adult Balb/c male mice. " 01/01/2014 - "A significant neurologic complication of pyridoxine therapy is peripheral neuropathy thought to be a result of long-term and high dose usage. "
4.	Anemia 03/10/1994 - "In expression studies, the activity of the mutant enzyme was reduced relative to that of the wild type, and this reduction was comparable to that in erythroid cells of the proband during relapse of the anemia; the enzyme activity expressed in the presence of pyridoxine was comparable to that in the proband's marrow cells during remission. " 07/01/2006 - "The anemia is associated with a previously unrecognized ALAS2 mutation (Arg436Trp) and is unresponsive to pyridoxine. " 05/01/2004 - "Treatment with pyridoxine corrects moderately the anemia. " 12/15/2000 - "Treatment with pyridoxine completely corrected the anemia both in the proband and her grandson. " 04/01/1979 - "However, a microcytic, normochromic anemia was observed in groups fed high dietary levels of pyridoxine (20 mg/kg or greater). "
5.	Poisoning 05/01/2010 - "For poisonings in which the amount of INH ingested is known, pyridoxine is dosed on a gram-for-gram basis. " 07/01/2001 - "Effects of pyridoxine infusion on base deficit in amounts given for INH poisoning have not been studied in human subjects. " 06/01/1992 - "Experimental Albizia versicolor poisoning in sheep and its successful treatment with pyridoxine hydrochloride." 01/01/1983 - "Pyridoxine IV is efficacely used in such poisoning." 01/01/1955 - "[Acute methyl bromide poisoning; rapid improvement in the sequellae, following massive doses of pyridoxine]."

Related Drugs and Biologics

1.	Vitamin B 6
2.	Folic Acid (Vitamin M)
3.	Isoniazid (Ftivazide)
4.	Vitamin B 12 (Cyanocobalamin)
5.	Thiamine (Aneurin)
6.	Vitamins
7.	Homocysteine
8.	Magnesium
9.	Doxylamine
10.	Niacin (Nicotinic Acid)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Renal Dialysis (Hemodialysis)
3.	Electrodes (Electrode)
4.	Psychology Biofeedback (Biofeedback)
5.	Ligation