[Iatrogenic diffuse interstitial pneumonia linked to 5-aminosalicylate].

Abstract

Iatrogenic pneumonias to sulphasalazine are most usually seen during the course of a haemorrhagic proctocolitis (RCH). We report a case in which a young woman was treated with 5-aminosalicylate (Pentasa) and prednisolone during an exacerbation of RCH. After 3 months of treatment the steroid therapy was stopped and the Pentasa was continued at the same dose (3 g per day). She presented with increasing dyspnoea on effort. Clinical examination was normal but a CT scan of the chest showed interstitial micro nodules; there was also a restrictive ventilatory disorder, hypoxaemia on effort and an alveolar eosinophilia (1.8%) The clinical progress, respiratory and blood gases all improved rapidly after stopping the Pentasa with the disappearance of the interstitial nodule over 5 months, suggesting that the role of the Pentasa was causal in the genesis of the pneumonia.

• Authors: D Declerck, B Wallaert, G Demarcq-Delerue, A B Tonnel
• Journal: Revue des maladies respiratoires (Rev Mal Respir) Vol. 11 Issue 3 Pg. 292-3 ( 1994) ISSN: 0761-8425 [Print] France
• Vernacular Title: Pneumopathie interstitielle diffuse iatrogène liée au 5-aminosalycilate.
• PMID: 8041994 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Aminosalicylic Acids
• Mesalamine
• Prednisolone

Topics

• Aminosalicylic Acids (adverse effects)
• Colitis (drug therapy)
• Drug Therapy, Combination
• Female
• Gastrointestinal Hemorrhage (drug therapy)
• Humans
• Lung Diseases, Interstitial (chemically induced)
• Mesalamine
• Middle Aged
• Prednisolone (therapeutic use)
• Proctitis (drug therapy)