Abstract | OBJECTIVE: DESIGN: A cohort study with measurements before and after the administration of interleukin-2. SETTING: Medical oncology department of a large teaching hospital. PATIENTS: MEASUREMENTS: MAIN RESULTS: Tumour necrosis factor-alpha rose from baseline levels of 32 (range, 12 to 56) to 343 (103 to 787) pg/ml 3 hours after interleukin-2 administration returning to baseline values 21 hours later. Interleukins-6 and -8 rose from baseline levels of 6 (5 to 10) and 75 (35 to 100) to 2151 (152 to 7259) and 1283 (490 to 2500) pg/ml, respectively, at 4 hours after interleukin-2 with both returning to baseline values by 24 hours. Peak levels of neutrophil elastase and lactoferrin, both markers of neutrophil activation, occurred 6 hours after interleukin-2 administration. CONCLUSIONS: These data indicate that following administration of interleukin-2 tumour necrosis factor-alpha is released followed sequentially by rises in interleukins-6 and -8. It is hypothesised that these events result in activation of polymorphonuclear neutrophils. These activated neutrophils may play an important role in initiating endothelial cell damage leading to the haemodynamic toxicity and the capillary leak syndrome which is typically seen following the administration of interleukin-2.
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Authors | J W Baars, G J Wolbink, M H Hart, C E Hack, A J Eerenberg-Belmer, H M Pinedo, J Wagstaff |
Journal | Annals of oncology : official journal of the European Society for Medical Oncology
(Ann Oncol)
Vol. 5
Issue 10
Pg. 929-34
(Dec 1994)
ISSN: 0923-7534 [Print] England |
PMID | 7696165
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article)
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Chemical References |
- Interleukin-2
- Interleukin-6
- Interleukin-8
- Tumor Necrosis Factor-alpha
- Interferon-gamma
- Lactoferrin
- Pancreatic Elastase
- Leukocyte Elastase
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Topics |
- Adult
- Aged
- Carcinoma, Renal Cell
(blood, immunology, therapy)
- Cohort Studies
- Female
- Humans
- Infusions, Intravenous
- Interferon-gamma
(therapeutic use)
- Interleukin-2
(administration & dosage, therapeutic use)
- Interleukin-6
(blood)
- Interleukin-8
(blood)
- Kidney Neoplasms
(blood, immunology, therapy)
- Lactoferrin
(blood)
- Leukocyte Count
- Leukocyte Elastase
- Male
- Melanoma
(blood, immunology, therapy)
- Middle Aged
- Neutrophil Activation
- Pancreatic Elastase
(blood)
- Tumor Necrosis Factor-alpha
(metabolism)
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