Abstract | BACKGROUND:
Extramammary Paget disease appears in anogenital, axillary, or other areas. In this study, the authors addressed the question of whether the histogenesis of 35 cases of Paget disease arising at different sites was the same. METHODS: RESULTS: CONCLUSIONS: Cases of Paget disease arising at different locations could not be distinguished from each other based on cytokeratin expression. In addition, antikeratin antibodies against simple epithelial keratins were demonstrated to be more useful for the identification of Paget cells in the paraffin sections than were conventional antibodies, such as an antibody against carcinoembryonic antigen (CEA).
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Authors | S Watanabe, T Ohnishi, H Takahashi, Y Ishibashi |
Journal | Cancer
(Cancer)
Vol. 72
Issue 11
Pg. 3323-30
(Dec 01 1993)
ISSN: 0008-543X [Print] United States |
PMID | 7694788
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Carcinoembryonic Antigen
- Protein Precursors
- involucrin
- Keratins
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Topics |
- Antibodies, Monoclonal
- Breast Neoplasms
(genetics, pathology)
- Carcinoembryonic Antigen
(analysis, genetics)
- Carcinoma
(genetics, pathology)
- Eccrine Glands
(pathology)
- Gene Expression Regulation, Neoplastic
- Humans
- Keratins
(analysis, classification, genetics)
- Neoplasm Invasiveness
- Paget Disease, Extramammary
(genetics, pathology)
- Paget's Disease, Mammary
(genetics, pathology)
- Protein Precursors
(analysis, genetics)
- Urogenital Neoplasms
(genetics, pathology)
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