Absence of sperm-specific lactate dehydrogenase-x in patients with testis cancer.

Abstract

LDH-x is a unique form of lactate dehydrogenase found in germinal epithelium during spermatogenesis. 53 patients with germ cell tumors were screened for the presence of LDH-x in the serum. No patient had detectable levels of the enzyme. 31 of the patients had elevated total serum LDH levels, and the isozyme fraction type 1 and/or type 2 was responsible for the elevation in all cases. LDH is a useful marker in germ cell tumors, but LDH-x is not the responsible isozyme.

• Authors: N J Vogelzang, P H Lange, E Goldberg
• Journal: Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine (Oncodev Biol Med) Vol. 3 Issue 4 Pg. 269-72 ( 1982) ISSN: 0167-1618 [Print] Netherlands
• PMID: 6291005 (Publication Type: Journal Article)

Chemical References

• Isoenzymes
• L-Lactate Dehydrogenase

Topics

• Clinical Enzyme Tests
• Dysgerminoma (enzymology)
• Humans
• Isoenzymes
• L-Lactate Dehydrogenase (blood, deficiency)
• Male
• Neoplasms, Germ Cell and Embryonal (enzymology)
• Spermatozoa (enzymology)
• Testicular Neoplasms (enzymology)